Newest Challenges and Advances in the Treatment of Colorectal Disorders; From Predictive Biomarkers to Minimally Invasive Techniques PDF Download
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Author: Francesk Mulita
Publisher: Frontiers Media SA
ISBN: 2832556027
Category : Medical
Languages : en
Pages : 220
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Book Description
Colorectal disorders have come to the forefront of modern endoscopic and minimally invasive surgery due to the significant incidence rates and effects on patient quality of life (QoL). Heralded by the rising diagnosis rates of early-onset colorectal cancer, surgical techniques on resection, lymph node harvesting, and bowel anastomosis have been rapidly advancing, in parallel to more minimally invasive approaches such as stenting, tattooing and endoscopic resection. While the role of the colorectal specialist surgeon is central in treating benign and malignant colorectal disease, we must further study the role of novel biomarkers, tumor genomics and proteomics, as well as the use of less invasive methods with regards to the prognosis and outcomes of such patients.
Author: Francesk Mulita
Publisher: Frontiers Media SA
ISBN: 2832556027
Category : Medical
Languages : en
Pages : 220
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Book Description
Colorectal disorders have come to the forefront of modern endoscopic and minimally invasive surgery due to the significant incidence rates and effects on patient quality of life (QoL). Heralded by the rising diagnosis rates of early-onset colorectal cancer, surgical techniques on resection, lymph node harvesting, and bowel anastomosis have been rapidly advancing, in parallel to more minimally invasive approaches such as stenting, tattooing and endoscopic resection. While the role of the colorectal specialist surgeon is central in treating benign and malignant colorectal disease, we must further study the role of novel biomarkers, tumor genomics and proteomics, as well as the use of less invasive methods with regards to the prognosis and outcomes of such patients.
Author: Xuelei Ma
Publisher: Frontiers Media SA
ISBN: 283253015X
Category : Medical
Languages : en
Pages : 264
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Book Description
Author: Massimo Pignatelli
Publisher: JP Medical Ltd
ISBN: 1907816852
Category : Medical
Languages : en
Pages : 192
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Book Description
Part of the Recent Advnaces series, Histopathology is a collection of comprehensive reviews, with emphasis on breakthroughs and their practical relevance to clinical practice, providing essential reading to help clinicians and trainees remain up to date in the field.
Author: Kevin M. Haigis, Ph.D.
Publisher: Springer Science & Business Media
ISBN: 146148412X
Category : Medical
Languages : en
Pages : 319
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Book Description
Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.
Author: Jose Luis Garcia-Gimenez
Publisher: Academic Press
ISBN: 0128019212
Category : Science
Languages : en
Pages : 698
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Book Description
Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. - Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics - Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics - Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications - Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases - Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies
Author: Gunjan Rehani
Publisher: CRC Press
ISBN: 1040302785
Category : Law
Languages : en
Pages : 207
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Book Description
The book emphasizes the role of data in driving healthcare transformation, providing readers with a roadmap for understanding and effectively implementing data-driven innovations. It delves into the applications of big data analytics, unveiling valuable insights and offering real-time decision support to healthcare professionals and goes on to review the role of machine learning and artificial intelligence in enabling accurate diagnosis, personalized treatment recommendations, and predictive modeling. The book is an invaluable resource for healthcare professionals, researchers, policymakers, and technology enthusiasts alike. Its practical insights and perspectives empower stakeholders to leverage data-driven technologies effectively, thus fostering continuous improvements in patient care and shaping a brighter future for the healthcare industry as a whole.
Author: Tomoharu Sugie
Publisher: Frontiers Media SA
ISBN: 2832500013
Category : Medical
Languages : en
Pages : 183
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Book Description
Author: Aldo Rocca
Publisher: Frontiers Media SA
ISBN: 2832556000
Category : Medical
Languages : en
Pages : 134
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Book Description
March is Colorectal Cancer Awareness Month and at Frontiers in Oncology we want to highlight the recent discoveries in the field and raise awareness of the importance of early diagnosis, multidisciplinary management, and technological innovation support. Colorectal cancer (CRC) is the third most common cancer worldwide and represents one of the most relevant challenges for present and future global health, with 50 % of patients affected by CRC developing metastasis. Despite the introduction of novel therapeutic approaches and anticancer drugs, colorectal metastatic cancer (mCRC) continue to have a poor prognosis. In the last years, the extensive investigation on biomarkers that could identify patients at high risk for metastasis and predict the response to therapies has deeply impacted the therapeutic approaches to patients with mCRC. The most established biomarkers for mCRC are microsatellite instability (MSI) or mismatch repair deficiency (dMMR), HER2 amplification, RAS/BRAF mutations, and sidedness. Immune checkpoint inhibitors (ICIs) have been extensively used to treat patients with microsatellite unstable or mismatch repair-deficient (dMMR) CRC, while patients harboring a BRAFV600E mutation benefit from combination therapy with chemotherapy and immunotherapy drugs. The success of biomarker-driven patient selection to improve the therapeutic response and the overall survival of patients with mCRC highlights the imperative need for further research to identify novel biomarkers for better patient-tailored therapy.
Author: Catherine Alix-Panabieres
Publisher: Frontiers Media SA
ISBN: 2832504515
Category : Science
Languages : en
Pages : 310
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Book Description
Author: Stella Pelengaris
Publisher: John Wiley & Sons
ISBN: 1118430859
Category : Science
Languages : en
Pages : 632
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Book Description
The Molecular Biology of Cancer, Stella Pelengaris & Michael Khan This capturing, comprehensive text, extensively revised and updated for its second edition, provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. “Bench to Bedside”: A key strength of this book that sets it apart from general cancer biology references is the interweaving of all aspects of cancer biology from the causes, development and diagnosis through to the treatment and care of cancer patients – essential for providing a broader view of cancer and its impact. The highly readable presentation of a complex field, written by an international panel of researchers, specialists and practitioners, would provide an excellent text for graduate and undergraduate courses in the biology of cancer, medical students and qualified practitioners in the field preparing for higher exams, and for researchers and teachers in the field. For the teaching of cancer biology, special features have been included to facilitate this use: bullet points at the beginning of each chapter explaining key concepts and controversial areas; each chapter builds on concepts learned in previous chapters, with a list of key outstanding questions remaining in the field, suggestions for further reading, and questions for student review. All chapters contain text boxes that provide additional and relevant information. Key highlights are listed below: An overview of the cancer cell and important new concepts. Selected human cancers: lung, breast, colorectal, prostate, renal, skin, cervix, and hematological malignancies. Key cellular processes in cancer biology including (a) traditionally important areas such as cell cycle control, growth regulation, oncogenes and tumour suppressors apoptosis, as well as (b) more highly topical areas of apoptosis, telomeres, DNA damage and repair, cell adhesion, angiogenesis, immunity, epigenetics, and the proteasome. Clinical oncology: In-depth coverage of important concepts such as screening, risk of cancer and prevention, diagnoses, managing cancer patients from start to palliative care and end-of-life pathways. Chapters highlighting the direct links between cancer research and clinical applications. New coverage on how cancer drugs are actually used in specific cancer patients, and how therapies are developed and tested. Systems Biology and cutting edge research areas covered such as RNA interference (RNAi). Each chapter includes key points, chapter summaries, text boxes, and topical references for added comprehension and review. Quotations have been used in each chapter to introduce basic concepts in an entertaining way. Supported by a dedicated website at www.blackwellpublishing.com/pelengaris We should list the great reviews we got for first edition which are on the back of the 2nd edition: “A capturing, comprehensive, clearly written and absolutely accurate introduction into cancer biology.....This book deserves great praise for the readable presentation of this complex field....the true synthesis of bench and bedside approaches is marvelously achieved.” Christian Schmidt, Molecular Cell “Chapters address the issues of cancer diagnosis, treatment, and patient care and set the book apart from general molecular biology references....This book is applicable to both graduate and undergraduate students, and in the context of a research laboratory, this book would be an excellent resource as a reference guide for scientists at all levels.” V.Emuss, Institute of Cancer Research, London. Also, from the first edition: “Pelengaris, Khan, and the contributing authors are to be applauded. The Molecular Biology of Cancer is a comprehensive and readable presentation of the many faces of cancer from molecular mechanisms to clinical therapies and diagnostics. This book will be welcomed by neophyte students, established scientists in other fields, and curious physicians.” -Dean Felsher, Stanford University
