New Trends in the Diagnosis and Therapy of Alzheimer’s Disease PDF Download
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Author: Kurt A. Jellinger
Publisher: Springer Science & Business Media
ISBN: 3709193761
Category : Medical
Languages : en
Pages : 201
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Book Description
Alzheimer ́s Disease (AD), the most frequent cause of mental decline in the elderly represents one of the major health problems facing modern society. Despite considerable progress in the clinical diagnosis, epidemiology, structural basis, biochemistry, molecular genetics, and pharmacological aspects of AD, its etiology, molecular backgrounds, and treatment challenges are still poorly understood. This volume based on the 2nd International Symposium of EBEWE Research Initiative in October 1993 in Salzburg, Austria, is conceived as a review of our current knowledge of morphology, diagnostic clinical and imaging techniques, methodological approaches of cognitive assessment, trial designs, outcome variables and possibilities of therapy of AD and other neurodegenerative disorders. The book ́s coverage is broad and it should be of interest for investigators, clinicians, and researchers involved in the problems of AD.
Author: Kurt A. Jellinger
Publisher: Springer Science & Business Media
ISBN: 3709193761
Category : Medical
Languages : en
Pages : 201
Get Book Here
Book Description
Alzheimer ́s Disease (AD), the most frequent cause of mental decline in the elderly represents one of the major health problems facing modern society. Despite considerable progress in the clinical diagnosis, epidemiology, structural basis, biochemistry, molecular genetics, and pharmacological aspects of AD, its etiology, molecular backgrounds, and treatment challenges are still poorly understood. This volume based on the 2nd International Symposium of EBEWE Research Initiative in October 1993 in Salzburg, Austria, is conceived as a review of our current knowledge of morphology, diagnostic clinical and imaging techniques, methodological approaches of cognitive assessment, trial designs, outcome variables and possibilities of therapy of AD and other neurodegenerative disorders. The book ́s coverage is broad and it should be of interest for investigators, clinicians, and researchers involved in the problems of AD.
Author: Kurt Jellinger
Publisher:
ISBN: 9783709168936
Category :
Languages : en
Pages : 300
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Book Description
Author: Harald Hampel
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805598025
Category : Medical
Languages : en
Pages : 200
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Book Description
How current biomarkers are modernizing the diagnosis of Alzheimer's disease Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer's disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the amyloid' or tau' hypotheses. This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs.
Author: Thimmaiah Govindaraju
Publisher: Royal Society of Chemistry
ISBN: 1839162740
Category : Medical
Languages : en
Pages : 531
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Book Description
Alzheimer’s disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition. Due to its multifactorial pathogenesis, current treatments are directed against symptoms and even precise diagnosis remains difficult as the majority of cases are diagnosed symptomatically and usually confirmed only by autopsy. Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities provides a comprehensive overview from aetiology and neurochemistry to diagnosis, evaluation and management of Alzheimer's disease, and latest therapeutic approaches. Intended to provide an introduction to all aspects of the disease and latest developments, this book is ideal for students, postgraduates and researchers in neurochemistry, neurological drug discovery and Alzheimer’s disease.
Author: Fotiadis, Dimitrios I.
Publisher: IGI Global
ISBN: 1466688297
Category : Health & Fitness
Languages : en
Pages : 690
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Book Description
Stemming from environmental, genetic, and situational factors, chronic disease is a critical concern in modern medicine. Managing treatment and controlling symptoms is imperative to the longevity and quality of life of patients with such diseases. The Handbook of Research on Trends in the Diagnosis and Treatment of Chronic Conditions features current research on the diagnosis, monitoring, management, and treatment of recurring diseases such as diabetes, Parkinson's disease, autoimmune disorders, and others. This handbook is intended for practitioners and researchers across various disciplines including, but not limited to, biology, biomedical engineering, computer science, and information and communication technologies. Aimed at identifying new disease determinants and the way in which new technologies can contribute to improved health outcomes, this handbook covers a variety of topics, including wearable and mobile technologies, capillaroscopy imaging, diagnostic and monitoring methods, and disease prediction modeling, among others.
Author: Eileen M. Welsh
Publisher: Nova Publishers
ISBN: 9781594549380
Category : Medical
Languages : en
Pages : 350
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Book Description
Dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. The most common form of dementia among older people is Alzheimer's Disease (AD), which involves the parts of the brain that control memory, thought and language. Age is the most important known risk factor for AD. The number of people with the disease doubles every 5 years beyond age 65. AD is a slow disease, starting with mild memory loss and ending with severe brain damage. The course the disease takes and how fast changes occur vary from person to person. On average, AD patients live from 8 to 10 years after they are diagnosed, though the disease can last for as many as 20 years. Current research is aimed at understanding why AD occurs and who is at greatest risk for developing it, improving the accuracy of diagnosis and ability to identify who is at risk, developing, discovering and testing new treatments for behavioural problems in patients with AD. This book gathers state-of-the-art research from leading scientists throughout the world which offers important information on understanding the underlying causes and discovering the most effective treatments for Alzheimer's Disease.
Author: Kurt A. Jellinger
Publisher: Springer Science & Business Media
ISBN: 3709168929
Category : Medical
Languages : en
Pages : 283
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Book Description
This volume gives an overview of the present state of art on the classification, neuropathology, clinical presentation, neuropsychology, diagnosis, neuroimaging and therapeutic possibilities in non-Alzheimer’s dementias, an increasingly important group of CNS diseases, which account for 7 to 30% of dementing disorders in adults and aged subjects, and thus, represent the second most frequent cause of dementia after Alzheimer’s disease. The monograph provides the newest information for neurologists, psychiatrists, dementia research workers, dementia clinicians, neuropathologists, neurobiologists, and practicing physicians.
Author: Ghulam Md Ashraf
Publisher: Springer Nature
ISBN: 9811396361
Category : Medical
Languages : en
Pages : 293
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Book Description
This book discusses the latest research into the highly prevalent neurodevelopmental disease most commonly associated with aging: Alzheimer’s disease (AD). Even after years of research, Alzheimer’s disease is still far from being cured. It presents a range of common symptoms in the form of behavioral and cognitive impairments. This book describes the symptoms and the biology behind them. The contents covers latest findings on the genetics involved and various factors and pathways influencing disease development. It also covers various non-pharmacological therapies like immunotherapy, use of natural products, and employing nanotechnology in both the detection and treatment of AD. This book also highlights the role of diet and nutrition in healthy aging. Given its scope, it offers a valuable asset for researchers and clinicians alike.
Author:
Publisher:
ISBN:
Category : Aging
Languages : en
Pages : 0
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Book Description
Author: Renee D. Wegrzyn
Publisher: CRC Press
ISBN: 1439827087
Category : Medical
Languages : en
Pages : 308
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Book Description
In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer’s disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer’s Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD. With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores: The basis of AD and the role of Aβ oligomers in development of disease Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies In vivo imaging diagnostic approaches Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.
