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Author: Istvan Berczi
Publisher: Elsevier
ISBN: 0123846927
Category : Science
Languages : en
Pages : 285
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Book Description
New Insights to Neuroimmune Biology investigates the mechanisms that and functions of the Neuroimmune Regulatory Supersystem. Covering molecular regulation of cytokines in brain astrocytes, immunoregulation by the sympathetic nervous system, circadian regulation of immune reactions, antigen recognition by the CNS, the modulation of the immune response by head injury, neurogenic inflammation, the role of tachykinins in asthma and allergic disease, defence and defeat reactions, cytokines, behavior and affective disorders, increased activity of type 1 helper T cell functions after reward stimulation.This book has relevance to the entire scientific community in Biology, Medicine and Veterinary medicine as it discusses molecular, cellular, organic and systemic aspects as well as the physological, pathophysiological and behavioral mechnisms which are involved in Neuroimmiune Biology.
Author: Istvan Berczi
Publisher: Elsevier
ISBN: 0123846927
Category : Science
Languages : en
Pages : 285
Get Book Here
Book Description
New Insights to Neuroimmune Biology investigates the mechanisms that and functions of the Neuroimmune Regulatory Supersystem. Covering molecular regulation of cytokines in brain astrocytes, immunoregulation by the sympathetic nervous system, circadian regulation of immune reactions, antigen recognition by the CNS, the modulation of the immune response by head injury, neurogenic inflammation, the role of tachykinins in asthma and allergic disease, defence and defeat reactions, cytokines, behavior and affective disorders, increased activity of type 1 helper T cell functions after reward stimulation.This book has relevance to the entire scientific community in Biology, Medicine and Veterinary medicine as it discusses molecular, cellular, organic and systemic aspects as well as the physological, pathophysiological and behavioral mechnisms which are involved in Neuroimmiune Biology.
Author: Valentin A. Pavlov
Publisher: Frontiers Media SA
ISBN: 2889455335
Category :
Languages : en
Pages : 222
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Book Description
The nervous system plays an important role in the regulation of immunity and inflammation. On the other hand unbalanced immune responses in inflammatory and autoimmune conditions may have a deleterious impact on neuronal integrity and brain function. Recent studies have characterized neural pathways communicating peripheral inflammatory signals to the CNS, and brain- and spinal cord-derived circuitries controlling various innate and adaptive immune responses and inflammation. A prototypical neural reflex circuit that regulates immunity and inflammation is the vagus nerve-based “inflammatory reflex”. Ongoing research has revealed cellular and molecular mechanisms underlying these neural circuits and indicated new therapeutic approaches in inflammatory and autoimmune disorders. Pharmacological and bioelectronic modulation of neural circuitry has been successfully explored in preclinical settings of sepsis, arthritis, inflammatory bowel disease, obesity-driven disorders, diabetes and other diseases. These studies paved the way to successful clinical trials with bioelectronic neuronal modulation in rheumatoid arthritis and inflammatory bowel disease. Dysregulated release of cytokines and other inflammatory molecules may have a severe impact on brain function. Brain inflammation (neuroinflammation), imbalances in brain neuronal integrity and neurotransmitter systems, and cognitive impairment are characteristic features of post-operative conditions, sepsis, liver diseases, diabetes and other disorders characterized by immune and metabolic dysregulation. Derangements in cytokine release also play a pivotal role in depression. Characteristic brain reactive antibodies in autoimmune conditions, including systemic lupus erythematosus and neuromyelitis optica, significantly contribute to brain pathology and cognitive impairment. These studies, and the simultaneous characterization of neuro-protective cytokines, identified new therapeutic approaches for treating neurological complications in inflammatory and autoimmune disorders. This Frontiers Research Topic is a forum for publishing research findings and methodological and conceptual advances at the intersection of immunology and neuroscience. We hope that presenting new insight into bi-directional neuro-immune communication in inflammation and autoimmunity will foster further collaborations and facilitate the development of new efficient therapeutic strategies.
Author: Michal Schwartz
Publisher: Yale University Press
ISBN: 0300203470
Category : Medical
Languages : en
Pages : 316
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Book Description
Pathbreaking research offers new hope for treating brain diseases and injuries and for maintaining brain health even into old age In the past, the brain was considered an autonomous organ, self-contained and completely separate from the body's immune system. But over the past twenty years, neuroimmunologist Michal Schwartz, together with her research team, not only has overturned this misconception but has brought to light revolutionary new understandings of brain health and repair. In this book Schwartz describes her research journey, her experiments, and the triumphs and setbacks that led to the discovery of connections between immune system and brain. Michal Schwartz, with Anat London, also explains the significance of the findings for future treatments of brain disorders and injuries, spinal cord injuries, glaucoma, depression, and other conditions such as brain aging and Alzheimer's and Parkinson's diseases. Scientists, physicians, medical students, and all readers with an interest in brain function and its relationship to the immune system in health and disease will find this book a valuable resource. With general readers in mind, the authors provide a useful primer to explain scientific terms and concepts discussed in the book.
Author: Golam Khandaker
Publisher: Cambridge University Press
ISBN: 1009038362
Category : Medical
Languages : en
Pages : 357
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Book Description
The rapidly growing field of immunopsychiatry combines expertise and insights from immunology, psychiatry and neuroscience to understand the role of inflammation and other immune processes in causing and treating mental illness. This represents a major shift in mental health science, traditionally focused on psychological and neuronal mechanisms of depression, psychosis and dementia. This book provides the first comprehensive overview of recent, inter-disciplinary research linking disordered function of the immune system to the brain and mental illness. It offers a broad and deep perspective on the implications of immune system involvement in psychiatric disorders, including a balanced focus on basic science and clinical applications. Chapters cover the scientific evidence linking immune processes to major mental illnesses such as schizophrenia, depression, anxiety and dementia. An invaluable guide for graduate students, doctors in training, scientific researchers and others interested in the link between the immune system and mental health.
Author: Golam Khandaker
Publisher: Cambridge University Press
ISBN: 110842404X
Category : Medical
Languages : en
Pages : 357
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Book Description
An essential book summarizing cutting-edge evidence on the role of the immune system and immunotherapies in psychiatric disorders.
Author: Umasuthan Navaneethaiyer
Publisher: Frontiers Media SA
ISBN: 2832524486
Category : Medical
Languages : en
Pages : 312
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Book Description
Author: Davide Malagoli
Publisher: Academic Press
ISBN: 012802013X
Category : Medical
Languages : en
Pages : 384
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Book Description
The Evolution of the Immune System: Conservation and Diversification is the first book of its kind that prompts a new perspective when describing and considering the evolution of the immune system. Its unique approach summarizes, updates, and provides new insights on the different immune receptors, soluble factors, and immune cell effectors. - Helps the reader gain a modern idea of the evolution of the immune systems in pluricellular organisms - Provides a complete overview of the most studied and hot topics in comparative and evolutionary immunology - Reflects the organisation of the immune system (cell-based, humoral [innate], humoral [adaptive]) without introducing further and misleading levels of organization - Brings concepts and ideas on the evolution of the immune system to a wide readership
Author: Tsuneya Ikezu
Publisher: Springer
ISBN: 3319440225
Category : Medical
Languages : en
Pages : 1045
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Book Description
The second edition of Neuroimmune Pharmacology bridges the disciplines of neuroscience, immunology and pharmacology from the molecular to clinical levels with particular thought made to engage new research directives and clinical modalities. Bringing together the foremost field authorities from around the world, Neuroimmune Pharmacology will serve as an invaluable resource for the basic and applied scientists of the current decade and beyond.
Author: Daniela Tropea
Publisher: Frontiers Media SA
ISBN: 2889453804
Category :
Languages : en
Pages : 586
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Book Description
Brain disorders, including neurological and neuropsychiatric conditions, represent a challenge for public health systems and society at large. The limited knowledge of their biology hampers the development of diagnostic tools and effective therapeutics. A clear understanding of the mechanisms that underlie the onset and progression of brain disorders is required in order to identify new avenues for therapeutic intervention. Overlapping genetic risk factors across different brain disorders suggest common linkages and pathophysiological mechanisms that underlie brain disorders. Methodological and technological advances are leading to new insights that go beyond traditional hypotheses. Taking account of underlying molecular, cellular and systems biology underlying brain function will play an important role in the classification of brain disorders in future. In this Research Topic, the latest advances in our understanding of biological mechanisms across different brain disorders are presented. The areas covered include developments in neurogenetics, epigenetics, plasticity, glial cell biology, neuroimmune interactions and new technologies associated with the study of brain function. Examples of how understanding of biological mechanisms are translating into research strategies that aim to advance diagnoses and treatment of brain disorders are discussed.
Author:
Publisher: Elsevier
ISBN: 0080559352
Category : Science
Languages : en
Pages : 609
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Book Description
This book opens a new page of neuro-immunobiology providing substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. The volume is a collection of complex, new data drawn from multiple areas of investigation in the field. The contents summarize current understanding on the presence and function of CNS cytokines and their receptors in a variety of CNS cells during health and disease. The chapters are a collection of complex, new data demonstrating the presence and synthesis of cytokines in brain cells, as well as their receptors on cell membranes in health and disease. The strength of the volume are the descriptions of the authors own investigations, together with those of others in the field pertaining to a large number of cytokines in brain function, as well as mechanisms involved in the development of CNS disorders, including multiple sclerosis and Alzheimer's disease. Also included are novel approaches to the treatment of CNS disorders based on new experimental data. The contributors to this volume are internationally known scientists and clinical researchers in their respective fields of investigation and treatment.*Opens a new page of neuro-immunobiology and provides substantive evidence for the promise of this field in the treatment of disease*Summarizes current understanding on the presence and function of central nervous system (CNS) cytokines and their receptors in a variety of CNS cells during health and disease*Includes novel approaches to the treatment of CNS disorders based on new experimental data*Offers new insight into triggers for the development of autoimmune diseases in the brain and the possibilities for treatment
