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Author: Morteza Rasoulianboroujeni
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
This study aimed to develop a safe and scalable method for fabricating drug-loaded polymeric micelles while addressing the challenges of long-term storage. Current fabrication methods present serious challenges in the development procedure, including the utilization of toxic solvents, the requirement for specialized equipment, and difficulties in solid form production. We hypothesized that by utilizing low molecular weight PEGs, known for their ability to dissolve hydrophobic drugs at elevated temperatures, as an alternative solvent, these challenges could be overcome in the production of drug-loaded micelles.We first focused on investigating micelle formation in a copolymer/PEG/water mixture using a model based on mean-field lattice theory. The model considered the free energy and translational entropy of the micelles, revealing the existence of entropy-driven liquid-liquid phase separation (LLPS) preceding micelle formation. This event can be controlled by varying the degree of polymerization. Experimental validation confirmed the accuracy of the model using PEG4kDa-b-PLA2.2kDa as the copolymer and PEG as the solvent. Building on this system, we introduced the "PEG-assist" method for fabricating drug-loaded polymeric micelles by hydrating a mixture of PEG, copolymer, and drug. The properties of the resulting micelles were influenced by the molecular weight of PEG and temperature, both areknown to impact LLPS and solvation power of PEG. The method's adaptability to other drugs and copolymers, scalability, freeze-drying feasibility, and stability were also proved. Furthermore, we proposed a formulation strategy for producing drug-loaded polymeric micelles directly from solid drug-loaded copolymer crystals. The crystals formed through crystallization from a supersaturated solution of the copolymer and drug in low molecular weight PEG. Parameters like PEG molecular weight and crystallization conditions were found to impact the formation of drug-loaded micelles through hydration and the properties of the resulting micelles. In summary, this study presents a comprehensive approach for fabricating drug-loaded polymeric micelles from a physical chemistry perspective, providing alternatives to current fabrication methods.
Author: Morteza Rasoulianboroujeni
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
This study aimed to develop a safe and scalable method for fabricating drug-loaded polymeric micelles while addressing the challenges of long-term storage. Current fabrication methods present serious challenges in the development procedure, including the utilization of toxic solvents, the requirement for specialized equipment, and difficulties in solid form production. We hypothesized that by utilizing low molecular weight PEGs, known for their ability to dissolve hydrophobic drugs at elevated temperatures, as an alternative solvent, these challenges could be overcome in the production of drug-loaded micelles.We first focused on investigating micelle formation in a copolymer/PEG/water mixture using a model based on mean-field lattice theory. The model considered the free energy and translational entropy of the micelles, revealing the existence of entropy-driven liquid-liquid phase separation (LLPS) preceding micelle formation. This event can be controlled by varying the degree of polymerization. Experimental validation confirmed the accuracy of the model using PEG4kDa-b-PLA2.2kDa as the copolymer and PEG as the solvent. Building on this system, we introduced the "PEG-assist" method for fabricating drug-loaded polymeric micelles by hydrating a mixture of PEG, copolymer, and drug. The properties of the resulting micelles were influenced by the molecular weight of PEG and temperature, both areknown to impact LLPS and solvation power of PEG. The method's adaptability to other drugs and copolymers, scalability, freeze-drying feasibility, and stability were also proved. Furthermore, we proposed a formulation strategy for producing drug-loaded polymeric micelles directly from solid drug-loaded copolymer crystals. The crystals formed through crystallization from a supersaturated solution of the copolymer and drug in low molecular weight PEG. Parameters like PEG molecular weight and crystallization conditions were found to impact the formation of drug-loaded micelles through hydration and the properties of the resulting micelles. In summary, this study presents a comprehensive approach for fabricating drug-loaded polymeric micelles from a physical chemistry perspective, providing alternatives to current fabrication methods.
Author: Prashant Kesharwani
Publisher: Woodhead Publishing
ISBN: 0323886299
Category : Technology & Engineering
Languages : en
Pages : 716
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Book Description
Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles. Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles – such as mucosal and transdermal – and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation. Explores how polymeric micelles can be utilized in a range of different drug delivery approaches, from traditional oral delivery to ocular and dermal delivery Describes the various polymer types used in the synthesis and characterization of polymeric micelles Covers recent advances in polymeric micelles, such as drug co-delivery, triblock polymeric micelles, delivery of genetic materials, and more
Author: Sachin Kumar Singh
Publisher: Springer Nature
ISBN: 9819903610
Category : Medical
Languages : en
Pages : 302
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Book Description
This book thoroughly reviews the advancements in design and applications of Polymeric Micelles (PMs) in drug delivery. It provides information on the synthesis of amphiphilic block copolymers and their types, functional chemistry for targeting and sensing, and biomedical applications. The book further provides the possibilities for designing PMs in a range of drug delivery approaches. The book addresses the molecular parameters of amphiphilic block copolymers that are required for functionalizing PMs for drug delivery applications. Additionally, the book presents recent advances in applications of PMs such as co-delivery, sensing, theranostics, delivery of nucleic acids, and proteins. Towards the end, it discusses different physico-chemical strategies to enhance the stability and drug retention of polymeric micelles and reviews the preclinical and clinical toxicity and immunogenicity-related aspects of polymeric micelles. This book is an invaluable source for academics, research, and industry professionals working in the field of polymeric micelles and drug delivery.
Author: Alexandru Mihai Grumezescu
Publisher: William Andrew
ISBN: 0128172614
Category : Medical
Languages : en
Pages : 720
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Book Description
Nanoarchitectonics in Biomedicine describes this new area of nanoscience that has emerged as a major branch of nanoscience. The book brings together recent applications and discusses the advantages and disadvantages of each process, offering international perspectives on the technologies based on these findings. It offers new insights for nanoarchitectonics, starting with the currently used methods of synthesis and characterization of such materials, along with their biomedical applications. Authored by a wide range of international scientists, this volume shows how nanoarchitectonics is being used to create more efficient medical treatment solutions. Users will find this to be an important research resource for those wanting to learn more on the emerging topic of nanoarchitectonics in biomedical science. Explores how design aspects, smart materials and personalized materials are used in biomedicine today Offers global perspectives on how nanoarchitectonics is used in different regions Presents an important research resource for those wanting to learn more on the emerging topic of nanoarchitectonics in biomedical science
Author: Ijeoma F. Uchegbu
Publisher: CRC Press
ISBN: 9780849325335
Category : Medical
Languages : en
Pages : 280
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Book Description
Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we’ve seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene therapy. While Polymers in Drug Delivery offers much new insight for the veteran specialist, this work has been compiled with the non-specialist in mind. It includes contributions from many of the world’s leading drug delivery specialists, yet avoids jargon and presents background information that initiates the next generation of scientists into the amazing work going on at the frontiers of this rapidly evolving science. Targeting specific issues at the forefront of drug delivery today, this engaging volume— · Outlines the issues that must be considered when selecting a polymer for fabricating a drug delivery agent or other medical devices · Explains the more commonly used methods by which polymers may be characterized prior to use · Profiles polymer matrices that have been used in the formulation of solid oral dosage forms, drug delivery scaffolds, and hydrogels · Examines the issues surrounding the encapsulation of biologics within microspheres · Explores the use of nanoparticulates, especially solid nanoparticles and nanocapsules prepared from largely-water-insoluble cyanoacrylate polymers · Discusses polymeric micelles and investigates the potential of soluble polymer prodrugs and polymer nanomedicines · Details the contribution made by polymers and dendrimers to the gene delivery effort, which may one day lead to effective treatments for largely incurable diseases Noting a dramatic paradigm shift that is bridging the gap between materials science and life science, the editor’s have compiled this volume to paint an interdisciplinary portrait of drug delivery that will challenge young scientists to turn their attention and effort towards this critical branch of biomedicine. Containing state-of-the-art information for drug delivery scientists, it is also a great choice for medical and pharmaceutical students and others seeking an in-depth introduction to the field.
Author: Alexandru Mihai Grumezescu
Publisher: William Andrew
ISBN: 0128136286
Category : Science
Languages : en
Pages : 769
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Book Description
Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry
Author: Glen S. Kwon
Publisher: CRC Press
ISBN: 9780824725327
Category : Medical
Languages : en
Pages : 680
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Book Description
Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.
Author: Zachary L. Tyrrell
Publisher:
ISBN: 9781267110893
Category : Cancer
Languages : en
Pages : 137
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Book Description
Micelles formed through the self-assembly of block copolymers have been widely used to encapsulate highly hydrophobic drugs to increase their effective solubility. However, this emerging nanoparticle technology faces fabrication challenges that call for better understanding of the underlying principles that result in effective micelle-based drug delivery systems. Among the challenges, for example, are how to consistently prepare micelles with a narrow, predictable size-distribution and a high drug loading content, which remain stable upon dilution but dissociate upon reaching the target. For example, micelles of hydrophilic-hydrophobic block polymers, such as poly(ethylene glycol)- block -poly([varepsilon]-caprolactone) (PEG-b-PCL) have been shown to improve the pharmacokinetics and therapeutic efficacy of hydrophobic cancer drugs, such as paclitaxel. However, conventional drug encapsulation methods using incompressible aqueous and organic solvents are limited by lack of control over the micellization process, which results in drug loading around 3 wt% and encapsulation efficiencies of around 30%. An alternative is to use near-critical fluid solvents, such as trifluoromethane and dimethyl ether, to prepare drug loaded micelles under high pressure conditions, then release the solvent, which evaporates almost instantaneously, and rediperse the resulting nanoparticles in water. By controlling the drug precipitation within the micellar solution region of the near-critical solvent, the loading of paclitaxel in PEG-b-PCL can reach over 12 wt% with encapsulation efficiencies approaching 100%. Additionally, nanoparticles have also been prepared that slow down the burst release of encapsulated drug, commonly observed upon dilution: for one particular case the release of paclitaxel upon dilution from is reduced from 19% to 2% at one hour and 50% to 39% at five hours. This new near-critical fluid micellization (NCFM) method will enable the preparation of drug-loaded nanoparticles that promise not only a lower exposure of the body to the copolymer at the same treatment drug-rate, due to the high drug loading, but also for less waste of the expensive drug, due to the high efficiency, enabling the efficient fabrication of stable, well-defined nanoparticles for revolutionary new cancer treatments.
Author: Shyam Mohapatra
Publisher: Elsevier
ISBN: 0128140305
Category : Science
Languages : en
Pages : 684
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Book Description
Applications of Targeted Nano-Drugs and Delivery Systems: Nanoscience and Nanotechnology in Drug Delivery explores the applications of Nano-drugs and their delivery systems, investigating the role they can play in key body systems and major diseases. The book explores how nanotechnology can be deployed in developing new drug delivery systems and how they enable pharmaceutical companies to reformulate existing drugs on the market, thereby extending the lifetime of products and enhancing performance by increasing effectiveness, safety and patient adherence, and ultimately reducing healthcare cost. Reflecting the interdisciplinary nature of the subject matter, this book includes contributions by experts from different fields. Readers will find a reference and practical source of guidance for researchers, students and scientists working in the fields of nanotechnology, materials science, and technology and biomedical science. Enables readers from different fields to access recent research and protocols across traditional boundaries Focuses on protocols and techniques, as well as the knowledge base of the field, thus enabling those in R&D to learn about, and successfully deploy, cutting-edge techniques Explores the applications of Nano-drugs and their delivery systems, investigating the role they can play in key body systems and major disease types
Author: Redouane Borsali
Publisher: Springer Science & Business Media
ISBN: 140204464X
Category : Science
Languages : en
Pages : 1490
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Book Description
This 2-volume set includes extensive discussions of scattering techniques (light, neutron and X-ray) and related fluctuation and grating techniques that are at the forefront of this field. Most of the scattering techniques are Fourier space techniques. Recent advances have seen the development of powerful direct imaging methods such as atomic force microscopy and scanning probe microscopy. In addition, techniques that can be used to manipulate soft matter on the nanometer scale are also in rapid development. These include the scanning probe microscopy technique mentioned above as well as optical and magnetic tweezers.
