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Author: Aliasghar Tabatabaei Mohammadi
Publisher: Nobel Sciences
ISBN:
Category : Medical
Languages : en
Pages : 68
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Book Description
Author: Aliasghar Tabatabaei Mohammadi
Publisher: Nobel Sciences
ISBN:
Category : Medical
Languages : en
Pages : 68
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Book Description
Author: Mark E. Bunnage
Publisher: Royal Society of Chemistry
ISBN: 184973125X
Category : Medical
Languages : en
Pages : 329
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Book Description
This book highlights the new frontiers in chemical biology and describes their impact and future potential in drug discovery.
Author: Jianfeng Feng
Publisher: Springer Science & Business Media
ISBN: 1849961964
Category : Science
Languages : en
Pages : 411
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Book Description
Biological and biomedical studies have entered a new era over the past two decades thanks to the wide use of mathematical models and computational approaches. A booming of computational biology, which sheerly was a theoretician’s fantasy twenty years ago, has become a reality. Obsession with computational biology and theoretical approaches is evidenced in articles hailing the arrival of what are va- ously called quantitative biology, bioinformatics, theoretical biology, and systems biology. New technologies and data resources in genetics, such as the International HapMap project, enable large-scale studies, such as genome-wide association st- ies, which could potentially identify most common genetic variants as well as rare variants of the human DNA that may alter individual’s susceptibility to disease and the response to medical treatment. Meanwhile the multi-electrode recording from behaving animals makes it feasible to control the animal mental activity, which could potentially lead to the development of useful brain–machine interfaces. - bracing the sheer volume of genetic, genomic, and other type of data, an essential approach is, ?rst of all, to avoid drowning the true signal in the data. It has been witnessed that theoretical approach to biology has emerged as a powerful and st- ulating research paradigm in biological studies, which in turn leads to a new - search paradigm in mathematics, physics, and computer science and moves forward with the interplays among experimental studies and outcomes, simulation studies, and theoretical investigations.
Author: Lance D. Chambers
Publisher: CRC Press
ISBN: 1420050079
Category : Mathematics
Languages : en
Pages : 438
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Book Description
The mathematics employed by genetic algorithms (GAs)are among the most exciting discoveries of the last few decades. But what exactly is a genetic algorithm? A genetic algorithm is a problem-solving method that uses genetics as its model of problem solving. It applies the rules of reproduction, gene crossover, and mutation to pseudo-organism
Author: Andrew J. Wood
Publisher: Springer Science & Business Media
ISBN: 0306485680
Category : Nature
Languages : en
Pages : 208
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Book Description
The mosses (Bryophatea, Musci) are a diverse and widely distributed group of land plants. Mosses are attractive experimental plants because they exhibit the traditional attributes of good model systems (Le. ease of growth & maintenance, fast generation time, and amenable genetics) with the added advantage of a haploid gametophyte that allowed developmental mutants to be recovered with relative ease. In addition, mosses with the ability to tolerate extreme environmental conditions offer realistic models for the analysis of environmental stress-tolerance; particularly when compared to tracheophytes such as Arabidopsis thaliana in which these important plant phenotypes are either not clearly expressed or entirely lacking. And, in one of the most exciting developments in Plant Biology, efficient homologous recombination occurs in the moss Physcomitrella patens. The ability to perform efficient homologous recombination (Le. gene knock-outs) in P. patens is at present unique amongst all plants and represents an extremely powerful technique for the functional analysis of many plant genes. Over the past 5 years, a world-wide community of moss researchers has evolved. A highly successful "Moss" conference has been held annually (l998-Mumbai, India; 1999-Carbondale, IL, USA; 2000-Villars, Switzerland; 200l-0kazaki, Japan; 2002-Ambleside, UK; 2003-St. Louis, MO, USA) with "Moss 2004" planned to be held in Frieburg Germany. These conferences have been instrumental in the creation & development of strong collaborative ties, and the free exchange of both ideas and materials.
Author: Yuan-Ming Zhang
Publisher: Frontiers Media SA
ISBN: 2889458342
Category :
Languages : en
Pages : 236
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Book Description
Genome-Wide Association Studies (GWAS) are widely used in the genetic dissection of complex traits. Most existing methods are based on single-marker association in genome-wide scans with population structure and polygenic background controls. To control the false positive rate, the Bonferroni correction for multiple tests is frequently adopted. This stringent correction results in the exclusion of important loci, especially for GWAS in crop genetics. To address this issue, multi-locus GWAS methodologies have been recommended, i.e., FASTmrEMMA, ISIS EM-BLASSO, mrMLM, FASTmrMLM, pLARmEB, pKWmEB and FarmCPU. In this Research Topic, our purpose is to clarify some important issues in the application of multi-locus GWAS methods. Here we discuss the following subjects: First, we discuss the advantages of new multi-locus GWAS methods over the widely-used single-locus GWAS methods in the genetic dissection of complex traits, metabolites and gene expression levels. Secondly, large experiment error in the field measurement of phenotypic values for complex traits in crop genetics results in relatively large P-values in GWAS, indicating the existence of small number of significantly associated SNPs. To solve this issue, a less stringent P-value critical value is often adopted, i.e., 0.001, 0.0001 and 1/m (m is the number of markers). Although lowering the stringency with which an association is made could identify more hits, confidence in these hits would significantly drop. In this Research Topic we propose a new threshold of significant QTN (LOD=3.0 or P-value=2.0e-4) in multi-locus GWAS to balance high power and low false positive rate. Thirdly, heritability missing in GWAS is a common phenomenon, and a series of scientists have explained the reasons why the heritability is missing. In this Research Topic, we also add one additional reason and propose the joint use of several GWAS methodologies to capture more QTNs. Thus, overall estimated heritability would be increased. Finally, we discuss how to select and use these multi-locus GWAS methods.
Author: George Poste
Publisher: Springer Science & Business Media
ISBN: 1461318459
Category : Medical
Languages : en
Pages : 213
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Book Description
Author: Daniel Navon
Publisher: University of Chicago Press
ISBN: 022663809X
Category : Medical
Languages : en
Pages : 409
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Book Description
With every passing year, more and more people learn that they or their young or unborn child carries a genetic mutation. But what does this mean for the way we understand a person? Today, genetic mutations are being used to diagnose novel conditions like the XYY, Fragile X, NGLY1 mutation, and 22q11.2 Deletion syndromes, carving out rich new categories of human disease and difference. Daniel Navon calls this form of categorization “genomic designation,” and in Mobilizing Mutations he shows how mutations, and the social factors that surround them, are reshaping human classification. Drawing on a wealth of fieldwork and historical material, Navon presents a sociological account of the ways genetic mutations have been mobilized and transformed in the sixty years since it became possible to see abnormal human genomes, providing a new vista onto the myriad ways contemporary genetic testing can transform people’s lives. Taking us inside these shifting worlds of research and advocacy over the last half century, Navon reveals the ways in which knowledge about genetic mutations can redefine what it means to be ill, different, and ultimately, human.
Author: Lance D. Chambers
Publisher: CRC Press
ISBN: 9781420050073
Category : Mathematics
Languages : en
Pages : 442
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Book Description
The mathematics employed by genetic algorithms (GAs)are among the most exciting discoveries of the last few decades. But what exactly is a genetic algorithm? A genetic algorithm is a problem-solving method that uses genetics as its model of problem solving. It applies the rules of reproduction, gene crossover, and mutation to pseudo-organism
Author: Marilena Streit-Bianchi
Publisher: Springer Nature
ISBN: 303161187X
Category :
Languages : en
Pages : 333
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Book Description
