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Author: Maya Sieber-Blum
Publisher: CRC Press
ISBN: 9780849340048
Category : Science
Languages : en
Pages : 296
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Book Description
The target of much current research, the neural crest is a transitory tissue of the vertebrate embryo that gives rise to many diverse structures in the adult organism, including the autonomic nervous system, the enteric nervous system, and most primary sensory ganglia, among other cell types and tissues. Reflecting recent investigations, Neurotrophins and the Neural Crest is dedicated to the roles neurotrophins play in neural crest cell differentiation and in the survival of neural crest derivatives. This timely book correlates in vitro data with results obtained from knock-out mice with targeted neurotrophin or receptor deletions, with the goal of determining the fidelity and usefulness of various experimental culture systems. It also covers embryonic expression patterns and functions of neurotrophins and their receptors. Chapters are organized to begin with neural crest-derived tissues as sources for experimental material, including sensory neurons, sympathetic neurons, enteric neurons, melanocytes, and calcitonin-producing cells from the thyroid, and concludes with discussions of the neural crest cells. A broad range of researchers and scientists involved in growth factors, neuroscience, developmental and cell biology, embryology, and many other fields, will find that Neurotrophins and the Neural Crest targets this fast-moving area of research completely and concisely.
Author: Maya Sieber-Blum
Publisher: CRC Press
ISBN: 9780849340048
Category : Science
Languages : en
Pages : 296
Get Book Here
Book Description
The target of much current research, the neural crest is a transitory tissue of the vertebrate embryo that gives rise to many diverse structures in the adult organism, including the autonomic nervous system, the enteric nervous system, and most primary sensory ganglia, among other cell types and tissues. Reflecting recent investigations, Neurotrophins and the Neural Crest is dedicated to the roles neurotrophins play in neural crest cell differentiation and in the survival of neural crest derivatives. This timely book correlates in vitro data with results obtained from knock-out mice with targeted neurotrophin or receptor deletions, with the goal of determining the fidelity and usefulness of various experimental culture systems. It also covers embryonic expression patterns and functions of neurotrophins and their receptors. Chapters are organized to begin with neural crest-derived tissues as sources for experimental material, including sensory neurons, sympathetic neurons, enteric neurons, melanocytes, and calcitonin-producing cells from the thyroid, and concludes with discussions of the neural crest cells. A broad range of researchers and scientists involved in growth factors, neuroscience, developmental and cell biology, embryology, and many other fields, will find that Neurotrophins and the Neural Crest targets this fast-moving area of research completely and concisely.
Author: Nicole Le Douarin
Publisher: Cambridge University Press
ISBN: 9780521620109
Category : Medical
Languages : en
Pages : 494
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Book Description
This 1999 edition of The Neural Crest contains comprehensive information about the neural crest, a structure unique to the vertebrate embryo, which has only a transient existence in early embryonic life. The ontogeny of the neural crest embodies the most important issues in developmental biology, as the neural crest is considered to have played a crucial role in evolution of the vertebrate phylum. Data that analyse neural crest ontogeny in murine and zebrafish embryos have been included in this revision. This revised edition also takes advantage of recent advances in our understanding of markers of neural crest cell subpopulations, and a full chapter is now devoted to cell lineage analysis. The major research breakthrough since the first edition has been the introduction of molecular biology to neural crest research, enabling an elucidation of many molecular mechanisms of neural crest development. This book is essential reading for students and researchers in developmental biology, cell biology, and neuroscience.
Author: A. Gorio
Publisher: Springer Science & Business Media
ISBN: 3642731481
Category : Science
Languages : en
Pages : 701
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Book Description
Data of all relevant aspects of neuronal cell growth and differentiation are presented in this volume. Regulation of expression, storage and release of nerve growth factors, receptor control and the cellular responses to growth factors are comprehensively discussed. Treated are also influences of various neurotransmitters on neuronal morphogenesis and new results of interactions of cells and mediators of the immune, endocrine and nervous system. Special emphasis is given to those factors regulating regeneration and nerve spreading after injuries of the nerve tissue.
Author: C. Bell
Publisher: Elsevier
ISBN: 0080529038
Category : Medical
Languages : en
Pages : 551
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Book Description
This volume provides an up-to-date survey of current thinking concerning the actions of chemical factors in the regulation of neuronal behaviour under normal and pathological conditions. The book is divided into four sections, dealing with chemical factors involved with the formation of axon pathways, factors involved with neuronal survival and specialization during normal development, factors involved in normal maintenance and repair of adult neurons and, finally, factors that have been implicated as mediators of degenerative changes in neurological and neuropsychiatric disorders.
Author: Bernhard H.J. Juurlink
Publisher: Springer Science & Business Media
ISBN: 1461519292
Category : Science
Languages : en
Pages : 311
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Book Description
The last decades have witnessed a radical change in our views on central nervous system damage and repair. This change is not only due to the emergence of new powerful tools for the analysis of the brain and its reactions to insults, but it also reflects a conceptual change in the way we approach these problems. As an illustration to this development, it is instructive to go back to the proceedings of a meeting at the NIH in 1955 edited by William F. Windle, which summarizes the disillusioned and pessimistic view on CNS regeneration prevailing at the time. While this generation of researchers were well aware of the issues at stake, they felt they had reached the end of the road; the approaches they had pursued had got stuck and the tools available could not take them any further. I can very well imagine that the participants, most of them leaders in the field, left that conference feeling they had heard their field being sentenced to death.
Author: Ira Black
Publisher: Springer Science & Business Media
ISBN: 1461327172
Category : Medical
Languages : en
Pages : 376
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Book Description
A central problem in neurobiology concerns mechanisms that generate the pro found diversity and specificity of the nervous system. What is the substance of diversification and specificity at the molecular, cellular, and systems levels? 4 How, for example, do 1011 neurons each form approximately 10 interconnec tions, allowing normal physiological function? How does disruption of these processes result in human disease? These proceedings represent the efforts of molecular biologists, embryologists, neurobiologists, and clinicians to approach these issues. in this volume are grouped by subject to present the varieties The chapters of methods used to approach each individual area. Section I deals with embry ogenesis and morphogenesis of the nervous system. In Chapter 3, Weston and co-workers describe the use of monoclonal antibodies that recognize specific neuronal epitopes (including specific gangliosides) for the purpose of defining heterogeneity in the neural crest, an important model system. Immunocyto chemical analysis reveals the existence of distinct sUbpopulations within the crest at extremely early stages; cells express neuronal or glial binding patterns at the time of migration. Consequently, interactions with the environment may select for predetermined populations. Le Douarin reaches similar conclusions in Chapter 1 by analyzing migratory pathways and developmental potentials in crest of quail-
Author: Maya Sieber-Blum
Publisher: World Scientific
ISBN: 9814343803
Category : Medical
Languages : en
Pages : 169
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Book Description
Offers readers an understanding of the development of neural crest cells, which is crucial as many birth defects and tumours are of neural crest origin. Delving into stem cells from different locations of the body, this book explores the best possible source of such cells for the use in medical applications.
Author: Katherine Elliott
Publisher: John Wiley & Sons
ISBN: 047071834X
Category : Medical
Languages : en
Pages : 192
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Book Description
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Author: Harvey B. Sarnat
Publisher: Elsevier Inc. Chapters
ISBN: 0128077417
Category : Medical
Languages : en
Pages : 22
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Book Description
Neural crest progenitor cells are identified at the lateral margins of the neural placode at the time of gastrulation. With folding of the placode, these precursors are brought to the dorsal midline of the neural tube at the site of closure, become committed to neural crest lineage and almost immediately migrate peripherally to various predetermined sites in the body and then differentiate as a variety of cellular types in all three of the traditional “germ layers.” All of these processes of migration and differentiation of neural crest are precisely genetically programed, temporally and spatially, by a variety of genes. Primary neurocutaneous syndromes are all very different diseases with different genetic mutations, but the unifying factor amongst them is that all are neurocristopathies and can be explained as such, including the tumor-suppressor function of several of these genes, especially those of neurofibromatosis 1 and 2 and tuberous sclerosis. This chapter reviews the principal genes that program neural crest development and also are documented, implicated, or suspected in the pathogenesis of neurocutaneous syndromes. Recent genetic discoveries are noted in epidermal nevus syndrome, including Proteus syndrome and their association with hemimegalencephaly and congenital infiltrating lipomatosis of the face.
Author: Brian K. Hall
Publisher: Springer Science & Business Media
ISBN: 1475730640
Category : Science
Languages : en
Pages : 322
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Book Description
A discussion of the neural crest and neural crest cells, dealing with their discovery, their embryological and evolutionary origins, their cellular derivatives - in both agnathan and jawed vertebrates or gnathostomes - and the broad topics of migration and differentiation in normal development. The book also considers what goes wrong when development is misdirected by mutations, or by exposure of embryos to exogenous agents such as drugs, alcohol, or excess vitamin A, and includes discussions of tumours and syndromes and birth defects involving neural crest cells.
