Author: G. Jean Harry
Publisher: CRC Press
ISBN: 1420054880
Category : Medical
Languages : en
Pages : 334
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Book Description
This new edition presents an integrated approach to neurotoxicology, the study of organisms’ responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects – from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs similar to neurodegenerative disorders such as Parkinson’s or Alzheimer’s disease. It is an essential resource for understanding the sites and mechanisms of neurotoxicity, for formulating testable hypotheses about the effects of neurotoxicants, and for improving the risk assessment process.
Author: Peter S. Spencer
Publisher: Spencer, Experimental and Clin
ISBN: 9780195084771
Category : Medical
Languages : en
Pages : 0
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Book Description
Two decades have passed since publication of the first edition of Experimental and Clinical Neurotoxicology pioneered the development of this discipline. Since then no other book has approached the breadth, scholarship, and balance of that landmark volume. For this long-awaited second edition,the original editors have been joined by Albert Ludolf, who brings expertise in biological neurotoxicology, and together with their distinguished contributors they have completely rewritten and reorganized the text.The scientific and clinical foundation is laid in three comprehensive introductory chapters. An overview of the biological basis of neurotoxicity provides the goundwork for discussing the scope of human and veterinary neurotoxic disease.The bulk of the text is devoted to an alphabeticaltreatment of chemicals with neurotoxic potential. This consists of tightly written overviews of the properties, actions, and mechanisms of all manner of substances, whether natural or synthetic. The neurotoxic side effects of experimental agents and of therapeutic as well as abused drugs arecovered extensively. Environmental pollutants, workplace contaminants, personal-use products, food additives, and agents harbored by plants, animals, and humans for use against their respective enemies are discussed. Each substance is rated on a three-point scale for the weight of evidenceindicating a specific neurotoxic effect in humans, animals, or laboratory models. These effects are summarized and cross-referenced in a series of appendices and an extensive index.In summary, the second edition establishes neurotoxicology as a scientific discipline that melds neurobiology, toxicology, and neurology. From this unique vantage point, the book examines in encyclopedic manner several hundred chemicals with the capacity to induce neurological illness in humansand animals. Indispensable for the experimental neuroscientist and toxicologist, as well as for practitioners of human and animal medicine, the book also provides an authoritative, critical, and pithy reference work for specialists in public health and the legal profession.
Author:
Publisher: Elsevier
ISBN: 0080468845
Category : Medical
Languages : en
Pages : 6448
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Book Description
An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version
Author: Michael R. Dobbs
Publisher: Elsevier Health Sciences
ISBN: 032307099X
Category : Medical
Languages : en
Pages : 729
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Book Description
Clinical Neurotoxicology offers accurate, relevant, and comprehensive coverage of a field that has grown tremendously in the last 20 years. You’ll get a current symptomatic approach to treating disorders caused by neurotoxic agents, environmental factors—such as heavy metals and pesticides—and more. Apply discussions of cellular and molecular processes and pathology to clinical neurology. Leading authorities and up-and-coming clinical neurotoxicologists present their expertise on wide-ranging, global subjects and debate controversies in the specialty, including Gulf War Syndrome. Provides a complete listing of neurotoxic agents—from manufactured to environmental—so you get comprehensive, clinical coverage. Covers how toxins manifest themselves according to age and co-morbidity so that you can address the needs of all your patients. Offers broad and in-depth coverage of toxins from all over the world through contributions by leading authorities and up-and-coming clinical neurotoxicologists. Features discussion of controversial and unusual topics such as Gulf War Syndrome, Parkinson’s Disease, motor neuron disease, as well as other issues that are still in question.
Author: John Timbrell
Publisher: CRC Press
ISBN: 9780415247634
Category : Medical
Languages : en
Pages : 238
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Book Description
Since the publication of the first edition of Introduction to Toxicology , toxicology has become a more mature science, the number of undergraduate and postgraduate courses has increased and thus the need for a regularly updated introductory text has become more pressing. This third edition caters for this need in a clear and easy-to-read style, featuring: * Up-to-the-minute information * Relevant toxicological examples that reinforce principles * End-of-chapter essay questions * New and redrawn illustrations * Glossary of terms * Extensively revised bibliography The fundamental principles of absorption, distribution, metabolism and excretion are described in the introductory chapters, as are the types of exposure and response. In subsequent chapters these are clarified with the use of carefully chosen examples. Among the topics considered are the potential adverse effects of drugs, pesticides, food additives and industrial chemicals.
Author: Thomas A Gossel
Publisher: CRC Press
ISBN: 9780781701259
Category : Medical
Languages : en
Pages : 464
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Book Description
In this third edition, the editors have accounted for the numerous changes in protocols for managing poison ingestions and have again provided an indispensable resource for all students of pharmacy and the health sciences on the basic principles of clinical toxicology. The book's unique focus on the fundamentals helps the reader understand why events occur and why a particular treatment is selected. Each chapter presents pertinent information on classes of toxic agents, their common sources and usual methods of intoxication, incidence and frequency of poisoning, mechanisms of action, clinical signs and symptoms of poisoning and management guidance. The text includes illustrative case studies, carefully selected to reinforce the information covered. Each chapter concludes with review questions to further enhance comprehension.
Author: William Slikker, Jr.
Publisher: Academic Press
ISBN: 0128093943
Category : Science
Languages : en
Pages : 616
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Book Description
Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience. Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition Contains new chapters that focus on subjects recent to the field Includes well-illustrated material, with diagrams, charts, and tables Contains compelling case studies and chapters written by world experts
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309045312
Category : Science
Languages : en
Pages : 167
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Book Description
Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
Author: Daniel Acosta
Publisher: CRC Press
ISBN: 9780415248693
Category : Medical
Languages : en
Pages : 616
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Book Description
Acosta's popular volume provides information on cardiovascular toxicology for clinicians, public health officials, industrial and experimental toxicologists, as well other interested professionals. This new edition highlights major advancements on the molecular aspects of toxicity to the cardiovascular system, including genomics information where appropriate. The book is divided into five sections: an introduction that emphasizes the need to explore biological mechanisms as factors in the toxicity of chemicals and drugs to the cardiovascular system, followed by sections addressing methods, principles of cell injury, cardiotoxicity of chemical agents, and vascular toxicity. The editor and all contributing authors are well established experts in their respective fields thus ensuring Cardiovascular Toxicology as the most authoritative and up-to-date review of this area of systematic toxicology.
Author: Stanley E. Manahan
Publisher: CRC Press
ISBN: 9781420032123
Category : Science
Languages : en
Pages : 456
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Book Description
This unique book bridges the gap between toxicology and chemistry at a level understandable by a wide spectrum of readers with various interests and a broad range of backgrounds in chemistry, biochemistry, and toxicology. The third edition has been thoroughly updated and expanded to reflect recent advances in important areas of research, including toxicogenetics and toxic effects on various body systems. Toxicological Chemistry and Biochemistry, Third Edition begins by outlining the basic concepts of general chemistry, organic chemistry, and biochemistry needed to understand the topics in the book. The author then presents an overview of environmental chemistry so that you can understand the remainder of the material covered within that framework. He also discusses biodegradation, bioaccumulation, and biochemical processes that occur in water and soil. The new chapter on toxic effects considers toxicities to the endocrine and reproductive systems, and the section on xenobiotics analysis deals with the determination of toxicants and their metabolites in blood and other biological materials. The chapter on the genetic aspects of toxicology discusses the ways in which chemical damage to DNA can cause mutations, cancer, and other toxic effects on specific body systems, and it considers the role of genetics in determining individual susceptibilities to various toxicants. Toxicological Chemistry and Biochemistry, Third Edition retains the basic information and structure that made the first two editions popular with students and industry professionals, while enhancing the usefulness of the book and modernizing it in important areas. Review questions and supplementary references at the end of each chapter round out the third edition of this bestselling work.
