Neural Crest Cells PDF Download
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Author: Paul Trainor
Publisher: Academic Press
ISBN: 0124045863
Category : Science
Languages : en
Pages : 488
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Book Description
Neural Crest Cells: Evolution, Development and Disease summarizes discoveries of historical significance and provides in-depth, current analyses of the evolution of neural crest cells, their contribution to embryo development, and their roles in disease. In addition, prospects for tissue engineering, repair and regeneration are covered, offering a timely synthesis of the current knowledge in neural crest cell research. A comprehensive resource on neural crest cells for researchers studying cell biology, developmental biology, stem cells and neurobiology, Neural Crest Cells: Evolution, Development and Disease provides foundational information needed for students , practicing physicians and dentists treating patients with craniofacial defects. - BMA Medical Book Awards 2014 - Highly Commended,Basic and Clinical Sciences,2014, British Medical Association - Provides timely, comprehensive synthesis of the current knowledge of neural crest cells - Covers the evolution and development of neural crest cells - Includes content on applications for tissue engineering, repair and regeneration
Author: Paul Trainor
Publisher: Academic Press
ISBN: 0124045863
Category : Science
Languages : en
Pages : 488
Get Book Here
Book Description
Neural Crest Cells: Evolution, Development and Disease summarizes discoveries of historical significance and provides in-depth, current analyses of the evolution of neural crest cells, their contribution to embryo development, and their roles in disease. In addition, prospects for tissue engineering, repair and regeneration are covered, offering a timely synthesis of the current knowledge in neural crest cell research. A comprehensive resource on neural crest cells for researchers studying cell biology, developmental biology, stem cells and neurobiology, Neural Crest Cells: Evolution, Development and Disease provides foundational information needed for students , practicing physicians and dentists treating patients with craniofacial defects. - BMA Medical Book Awards 2014 - Highly Commended,Basic and Clinical Sciences,2014, British Medical Association - Provides timely, comprehensive synthesis of the current knowledge of neural crest cells - Covers the evolution and development of neural crest cells - Includes content on applications for tissue engineering, repair and regeneration
Author:
Publisher: Alan R. Liss
ISBN:
Category : Medical
Languages : en
Pages : 244
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Book Description
Author: Jean-Pierre Saint-Jeannet
Publisher: Frontiers Media SA
ISBN: 2889668827
Category : Science
Languages : en
Pages : 213
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Book Description
Author:
Publisher:
ISBN: 9780845142493
Category :
Languages : en
Pages :
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Book Description
Author: Gisele da Silva Dalben
Publisher: Bentham Science Publishers
ISBN: 168108516X
Category : Medical
Languages : en
Pages : 178
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Book Description
Craniofacial Disorders – Orofacial Features and Peculiarities in Dental Treatment presents detailed information about craniofacial disorders and their features. The contents of the book cover craniofacial embryology, craniofacial genetics and teratology, craniofacial abnormalities (etiology, systemic involvement, and treatment methods and surgical steps required for complex dentomaxillofacial reconstruction for aesthetic or functional improvements. This book is an easy-to-read handbook for clinical dentists who wish to enhance their knowledge on the subject and offer dental care for individuals affected by craniofacial disorders.
Author: Philippa H. Francis-West
Publisher: Springer Science & Business Media
ISBN: 3642555705
Category : Science
Languages : en
Pages : 217
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Book Description
Craniofacial development is a multistep and intricate process initially involving a number of inductive interactions that control neural and neural crest development, which are followed by a series of epithelial-mesenchymal interactions that control outgrowth, patterning, and skeletal differentiation. Certain aspects of craniofacial development are unique developmental processes in higher vertebrates. First, in higher vertebrates the cranial neural crest, in contrast to the trunk neural crest, gives rise to the skeletal structures. These skeletal elements include those comprising mem brane bone and secondary cartilage, which with the exception of the clavicle are tissue types found exclusively in the head in higher vertebrates. Second, with the exception of the tongue, the origin of the musculature is distinct from other regions of the body. The body and tongue muscles are formed from the segmented epithelial somites whilst the head musculature is formed from unsegmented paraxial and prechordal mesoderm. Furthermore, the signalling cascades that control myogenic differentia tion appear to be distinct as determined by gene expression and the response of myogenic cells to growth factors. Finally, the neurogenic placodes, which give rise to the sensory organs and some cranial ganglia, are only found in the head. Over recent years, there have been significant advances in our knowledge of the molecular proc esses that control craniofacial development in a number of animal models. This has given insight into the genes that control many aspects of head development from the initial induction of the head to the final stages of differentiation.
Author: Sean Congdon
Publisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages :
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Book Description
The world health organization estimates that craniofacial defects affect between 2-3% of all live births, with complications ranging from aesthetic issues to severe mental retardation (Marcucio 2015). It is estimated that for a pathology resulting in craniofacial aberrations, each affected individual costs society ~1 million dollars in corrective and palliative care (Singh 2014). Current investigations into genetics underlying these defects have revealed 564 human (HPO 2017) and 3297 murine (MGI 2017) genes thought to be involved in craniofacial pathologies. Facial development requires a population of cells known as Cranial Neural Crest Cells (CNCCs) to properly migrate from the neural plate border and to populate the tissue of the future face (Douarin 2007). CNCCs are multipotent progenitors that respond to extrinsic signaling to make fate choices. Dysregulation of this process can result in craniofacial pathologies, such as clefting. Not only will understanding the genetic factors behind craniofacial development allow for better treatment of craniofacial disease, but can aid in genetic counseling to ultimately save millions of dollars in healthcare costs. Currently, discovery of genes involved with craniofacial development rely on high throughput genetic manipulations in animal models and/or epidemiological information obtained from human populations. These discoveries mainly employ top-down approaches to understand the genetics involved in craniofacial disorders. We propose that we can employ a bottom-upapproach to elucidate novel genetic components involved in normal craniofacial development to interrogate craniofacial diseases, chiefly, ones affecting craniofacial skeletal development. Our lab's focus is to resolve the transcriptic profile of populations of cells, using single-cell RNA sequencing during murine development. Of note is the ability of our lab to identify genes that co-vary with one another in populations of cells and are thought to coordinate genetic programs, a concept known as a metagene (Wilson 2012). Recently, our efforts have been to characterize populations of cells from theiler stage 19 (TS19) murine embryos, a developmental stage critical in craniofacial development (Kawauchi 2005). We propose three specific aims in order to evaluate craniofacial development in a bottom-up manner; (1) identify metagenes in putative CNCCs and osteoblastic progeny in our TS19 data set, (2) create a model system to interrogate CNCC metagene expression patterns and (3) perturb metagenes to broaden our understanding of CNCC fate decisions, particularly towards an osteoblastic fate. Our proposed research will broadly impact the field by expanding methods to evaluate genetic programs guiding fate decisions. These findings will help to identify novel genes participating in craniofacial development and can be used to understand genetic dysregulation occurring in craniofacial pathologies.
Author: Sebastian Dworkin
Publisher: Frontiers Media SA
ISBN: 2889749290
Category : Science
Languages : en
Pages : 144
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Book Description
Author: Robert M. Pratt
Publisher: North-Holland
ISBN:
Category : Health & Fitness
Languages : en
Pages : 480
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Book Description
Author: Nicole Le Douarin
Publisher: Cambridge University Press
ISBN: 9780521620109
Category : Medical
Languages : en
Pages : 494
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Book Description
This 1999 edition of The Neural Crest contains comprehensive information about the neural crest, a structure unique to the vertebrate embryo, which has only a transient existence in early embryonic life. The ontogeny of the neural crest embodies the most important issues in developmental biology, as the neural crest is considered to have played a crucial role in evolution of the vertebrate phylum. Data that analyse neural crest ontogeny in murine and zebrafish embryos have been included in this revision. This revised edition also takes advantage of recent advances in our understanding of markers of neural crest cell subpopulations, and a full chapter is now devoted to cell lineage analysis. The major research breakthrough since the first edition has been the introduction of molecular biology to neural crest research, enabling an elucidation of many molecular mechanisms of neural crest development. This book is essential reading for students and researchers in developmental biology, cell biology, and neuroscience.
