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Author: Gustavo Cudkowicz
Publisher: Elsevier
ISBN: 0323156495
Category : Medical
Languages : en
Pages : 313
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Book Description
Natural Resistance Systems Against Foreign Cells, Tumors, and Microbes presents the proceedings of an international conference held at Timber Cove Inn Jenner, California on October 18-22, 1976. It deals with the resistance to microorganisms and tumors, the dual problems of basic immunology, and the clinical aspects of immune reconstitution. It focuses on the identification and characterization of host defense systems, endowed with specificity, yet non-induced, non-adaptive, and non-thymus dependent. Divided into 12 chapters, the book initially discusses natural resistance to foreign hematopoietic and leukemic grafts. It goes on, examining the critical issues in clinical bone marrow transplantation and graft-versus-host (GVH) disease as a consequence of bone marrow grafting. Chapters 5 to 8 discuss the role of macrophage, Hh genes, major histocompatibility complex, and natural killer cell systems in natural resistance to normal and malignant cells. The final chapters cover the mechanism of cell's natural resistance to intracellular bacteria, genetic resistance to leukomogenesis, and manipulations to control the allograft response and GVH disease. This book is an invaluable resource for those interested in basic immunology, immune reconstitution, natural resistance phenomena, and GHV disease.
Author: Gustavo Cudkowicz
Publisher: Elsevier
ISBN: 0323156495
Category : Medical
Languages : en
Pages : 313
Get Book Here
Book Description
Natural Resistance Systems Against Foreign Cells, Tumors, and Microbes presents the proceedings of an international conference held at Timber Cove Inn Jenner, California on October 18-22, 1976. It deals with the resistance to microorganisms and tumors, the dual problems of basic immunology, and the clinical aspects of immune reconstitution. It focuses on the identification and characterization of host defense systems, endowed with specificity, yet non-induced, non-adaptive, and non-thymus dependent. Divided into 12 chapters, the book initially discusses natural resistance to foreign hematopoietic and leukemic grafts. It goes on, examining the critical issues in clinical bone marrow transplantation and graft-versus-host (GVH) disease as a consequence of bone marrow grafting. Chapters 5 to 8 discuss the role of macrophage, Hh genes, major histocompatibility complex, and natural killer cell systems in natural resistance to normal and malignant cells. The final chapters cover the mechanism of cell's natural resistance to intracellular bacteria, genetic resistance to leukomogenesis, and manipulations to control the allograft response and GVH disease. This book is an invaluable resource for those interested in basic immunology, immune reconstitution, natural resistance phenomena, and GHV disease.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Erle S. Robertson
Publisher: Springer
ISBN: 3030041557
Category : Medical
Languages : en
Pages : 406
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Book Description
This book ventures into a new and exciting area of discovery that directly ties our current knowledge of cancer to the discovery of microorganisms associated with different types of cancers. Recent studies demonstrate that microorganisms are directly linked to the establishment of cancers and that they can also contribute to the initiation, as well as persistence of, the cancers. Microbiome and Cancer covers the current knowledge of microbiome and its association with human cancers. It provides important reading for novices, senior undergraduates in cancer and microbiology, graduate students, junior investigators, residents, fellows and established investigators in the fields of cancer and microbiology. We cover areas related to known, broad concepts in microbiology and how they can relate to the ongoing discoveries of the micro-environment and the changes in the metabolic and physiologic states in that micro-environment, which are important for the ongoing nurturing and survival of the poly-microbial content that dictates activities in that micro-environment. We cover the interactions of microorganisms associated with gastric carcinomas, which are important for driving this particular cancer. Additional areas include oral cancers, skin cancers, ovarian cancers, breast cancers, nasopharyngeal cancers, lung cancers, mesotheliomas, Hodgkin’s and non-Hodgkin’s lymphomas, glioblastoma multiforme, hepatocellular carcinomas, as well as the inflammatory response related to the infectious agents in cancers. This book covers the metabolic changes that occur because of infection and their support for development of cancers, chronic infection and development of therapeutic strategies for detection and control of the infection. The field of microbiome research has exploded over the last five years, and we are now understanding more and more about the context in which microorganisms can contribute to the onset of cancers in humans. The field of microbiome research has demonstrated that the human body has specific biomes for tissues and that changes in these biomes at the specific organ sites can result in disease. These changes can result in dramatic differences in metabolic shifts that, together with genetic mutations, will produce the perfect niche for establishment of the particular infection programmes in that organ site. We are just beginning to understand what those changes are and how they influence the disease state. Overall, we hope to bring together the varying degrees of fluctuations in the microbiome at the major organ sites and how these changes affect the normal cellular processes because of dysregulation, leading to proliferation of the associated tissues.
Author: Robert A. Britton
Publisher: John Wiley & Sons
ISBN: 1683673026
Category : Medical
Languages : en
Pages : 725
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Book Description
Examining the enormous potential of microbiome manipulation to improve health Associations between the composition of the intestinal microbiome and many human diseases, including inflammatory bowel disease, cardiovascular disease, metabolic disorders, and cancer, have been elegantly described in the past decade. Now, whole-genome sequencing, bioinformatics, and precision gene-editing techniques are being combined with centuries-old therapies, such as fecal microbiota transplantation, to translate current research into new diagnostics and therapeutics to treat complex diseases. Bugs as Drugs provides a much-needed overview of microbes in therapies and will serve as an excellent resource for scientists and clinicians as they carry out research and clinical studies on investigating the roles the microbiota plays in health and disease. In Bugs as Drugs, editors Robert A. Britton and Patrice D. Cani have assembled a fascinating collection of reviews that chart the history, current efforts, and future prospects of using microorganisms to fight disease and improve health. Sections cover traditional uses of probiotics, next-generation microbial therapeutics, controlling infectious diseases, and indirect strategies for manipulating the host microbiome. Topics presented include: How well-established probiotics support and improve host health by improving the composition of the intestinal microbiota of the host and by modulating the host immune response. The use of gene editing and recombinant DNA techniques to create tailored probiotics and to characterize next-generation beneficial microbes. For example, engineering that improves the anti-inflammatory profile of probiotics can reduce the number of colonic polyps formed, and lactobacilli can be transformed into targeted delivery systems carrying therapeutic proteins or bioengineered bacteriophage. The association of specific microbiota composition with colorectal cancer, liver diseases, osteoporosis, and inflammatory bowel disease. The gut microbiota has been proposed to serve as an organ involved in regulation of inflammation, immune function, and energy homeostasis. Fecal microbiota transplantation as a promising treatment for numerous diseases beyond C. difficile infection. Practical considerations for using fecal microbiota transplantation are provided, while it is acknowledged that more high-quality evidence is needed to ascertain the importance of strain specificity in positive treatment outcomes. Because systems biology approaches and synthetic engineering of microbes are now high-throughput and cost-effective, a much wider range of therapeutic possibilities can be explored and vetted. If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.
Author: Bent Rolstad, M.D.
Publisher: CRC Press
ISBN: 9780849348372
Category : Medical
Languages : en
Pages : 258
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Book Description
Natural Immunity to Normal Hemopoietic Cells presents the first comprehensive compilation of experimental systems, theories, and views of the mechanisms behind NK cell recognition of normal hemopoietic cells. Leading scientists in the field have contributed chapters covering the role of Major Histocompatibility Complex (MHC) class I antigen expression of target cells in NK cell recognition, descriptions of NK allospecificities controlled by the MHC, and the role of alloreactive T cells and NK cells in acute bone marrow allograft rejection. Controversies between different theories are discussed in a balanced manner to convey a complete picture of the "state of the art." References give comprehensive, updated lists of current and previous research publications on this topic. The book is essential for immunologists, hematologists, clinical bone marrow transplantation researchers, and other scientists and students interested in recognition mechanisms of the immune system and the role of the MHC.
Author: Rodolphe Barrangou
Publisher: John Wiley & Sons
ISBN: 168367037X
Category : Science
Languages : en
Pages : 308
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Book Description
“An excellent compendium of all things CRISPR from some of the leading minds in the field. With thorough coverage from every angle and beautifully detailed illustrations, this book is not to be missed!” Jennifer A. Doudna, Professor of Chemistry, Biochemistry & Molecular Biology, UC Berkeley; Founder, Innovative Genomics Institute; Nobel Laureate and coinventor of CRISPR technology “This journey through CRISPR biology and several of its breakthrough applications offers an exciting glimpse into one of the most beautiful and compelling fields in the life sciences.” David R. Liu, Director of the Merkin Institute at the Broad Institute of MIT and Harvard; Professor of Chemistry and Chemical Biology at Harvard University; coinventor of base editing and prime editing “A must read! The CRISPR topics, written by world-leading experts, span from the fascinating mechanistic underpinnings to the ingenious applications. One can read from start to finish or pick and choose themes. Either way, the book delivers utterly enjoyable learning!” Bonnie Bassler, Squibb Professor and Chair, Princeton University Department of Molecular Biology; Howard Hughes Medical Institute Investigator CRISPR-Cas systems have revolutionized the science of gene editing and their possible applications continue to expand, from basic research to potentially groundbreaking medical and commercial uses. Led by a distinguished team of editors, CRISPR: Biology and Applications explores the subject matter needed to delve into this fascinating area. Topics covered include: Classification and molecular mechanisms of CRISPR-Cas systems CRISPR-Cas evolution, regulation, expression, and function Uses for gene editing and modulation of gene expression CRISPR-based antimicrobials and phage resistance for medical and industrial purposes Written by internationally renowned authors, CRISPR: Biology and Applications serves as both an introductory guide for those new to the field and an authoritative reference for seasoned researchers whose work touches this evolving and headline- making science.
Author: Emil Skamene
Publisher: Elsevier
ISBN: 032314439X
Category : Medical
Languages : en
Pages : 621
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Book Description
Genetic Control of Natural Resistance to Infection and Malignancy is a collection of papers presented at the 1980 Proceedings of an International Symposium of the Canadian Society for Immunology held in Montreal, Quebec. It provides information about the different models of genetic resistance to various diseases. The book offers an overview of the genetic determination of the susceptibility or resistance to infection and malignancy. It also discusses the importance of genetic resistance not only in the first-line observation of infections and tumors, but also in chemotherapy and immunotherapy. It then explains the genetic control of resistance to parasitic, bacterial, and virus infections, as well as to tumor growth. It further discusses the genetic control of macrophage differentiation and function.
Author: Rodolphe Barrangou
Publisher: Springer Science & Business Media
ISBN: 364234657X
Category : Science
Languages : en
Pages : 300
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Book Description
CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.
Author:
Publisher: Academic Press
ISBN: 0080860567
Category : Science
Languages : en
Pages : 643
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Book Description
Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. - Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease - Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow - Covers safety aspects, detection, identification and speciation - Includes techniques for the study of host interactions and reactions in animals and plants - Describes biochemical and molecular genetic approaches - Essential methods for gene expression and analysis - Covers strategies and problems for disease control
