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Author: Rosmarie Vogel
Publisher: Elsevier
ISBN: 0323160700
Category : Science
Languages : en
Pages : 174
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Book Description
Natural Proteinase Inhibitors focuses on natural inhibitors for proteolytic enzymes, which occur in plants and animals. It presents the theoretical and practical importance of the natural proteinase inhibitors of man and animal organisms. Organized into four chapters, this book starts with an overview of inhibitors for peptide and peptdohydrolases. This text then explores the important enzyme called kallikreins, which are found in the pancreas, the intestinal wall, the plasma, the submandibular gland, and the urine. Other chapters examine the various plant inhibitors, which are present in soybean, lima beans, potatoes, grains, and beetroots. This book discusses as well the inhibition of proteolytic enzymes by substances from body tissues. The final chapter deals with the prevention of uncontrolled liberation of kinins by proteinases, which is of great significance because the kinins are involved in the occurrence of pathological processes such as inflammation. Biologists and graduate students will find this book extremely useful.
Author:
Publisher: Academic Press
ISBN: 0080865968
Category : Technology & Engineering
Languages : en
Pages : 471
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Book Description
The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.
Author: Sajal Chakraborti
Publisher: Springer
ISBN: 9811031622
Category : Medical
Languages : en
Pages : 516
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Book Description
This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
Author:
Publisher: Academic Press
ISBN: 0128128313
Category : Medical
Languages : en
Pages : 448
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Book Description
Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy, Volume, Volume 148, the latest volume in the Progress in Molecular Biology and Translational Science series covers a variety of timely topics, with chapters focusing on The Role of Matrix Metalloproteinases in Development, Repair, and Destruction of the Lungs, Matrix Metalloproteinases in Kidney Disease: Role in Pathogenesis and Potential as a Therapeutic Target, Regulation of Matrix Metalloproteinase in the Pathogenesis of Diabetic Retinopathy, Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia, and Matrix Metalloproteinases, Neural Extracellular Matrix, and Central Nervous System Pathology. This volume is the second part of a thematic on matrix metalloproteinases and tissue remodeling in health and disease. It focuses on the role of MMPs in other systems, target tissues, and pathological disorders and the potential benefits of MMP inhibitors in various disorders. Serves as the second part of a thematic on matrix metalloproteinases and tissue remodeling in health and disease Focuses on cardiovascular remodeling Contains contributions from leading authorities on the topics Publishes cutting-edge reviews in molecular biology
Author: Satya Prakash Gupta
Publisher: Academic Press
ISBN: 0128181680
Category : Medical
Languages : en
Pages : 524
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Book Description
Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases.
Author: Rickey Y. Yada
Publisher: Springer Science & Business Media
ISBN: 1461526701
Category : Technology & Engineering
Languages : en
Pages : 214
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Book Description
Food proteins constitute a diverse and complex collection of biological macro molecules. Although contributing to the nutritional quality of the foods we con sume, proteins also act as integral components by virtue of their diverse functional properties. The expression of these functional properties during the preparation, processing and storage of foods is largely dictated by changes to the structure or structure-related properties of the proteins involved. Therefore, germane to the optimal use of existing and future food protein sources is a thorough understanding of the nature of the relationships between structure and function. It is the goal of this book to aid in better defining these relationships. Two distinct sections are apparent: firstly, those chapters which address struc ture-function relationships using a variety of food systems as examples to demonstrate the intricacies of this relationship, and secondly, those chapters which discuss techniques used to either examine structural parameters or aid in establishing quantitative relationships between protein structure and function. The editors would like to thank all contributors for their assistance, co-operation and, above all, their patience in putting this volume together, and the following companies/organizations for their financial support without which it would not have been the success it was: Ault Foods Limited, Best Foods Canada Limited, Natural Sciences and Engineering Research Council of Canada, Ontario Ministry of Agriculture and Food, Quest International Canada Inc., and University of Guelph. R.Y.Y. R.LJ.
Author: Axel Schmidt
Publisher: Springer Science & Business Media
ISBN: 9783764364625
Category : Medical
Languages : en
Pages : 258
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Book Description
-SARS has received much attention and coverage by the media and has a high impact on the public making this a hot research topic for scientists. -
Author: João C. Setubal
Publisher: Springer Nature
ISBN: 3030657752
Category : Science
Languages : en
Pages : 284
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Book Description
This book constitutes the refereed proceedings of the Brazilian Symposium on Bioinformatics, BSB 2020, held in São Paulo, Brazil, in November 2020. Due to COVID-19 pandemic the conference was held virtually The 20 revised full papers and 5 short papers were carefully reviewed and selected from 45 submissions. The papers address a broad range of current topics in computational biology and bioinformatics.
Author: Jay Fox
Publisher: MDPI
ISBN: 3038424269
Category : Science
Languages : en
Pages : 277
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Book Description
This book is a printed edition of the Special Issue "Snake Venom Metalloproteinases" that was published in Toxins
Author: Paula B. Andrade
Publisher: John Wiley & Sons
ISBN: 3527342052
Category : Medical
Languages : en
Pages : 348
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Book Description
The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
Author: Yehudith Birk
Publisher: Springer Science & Business Media
ISBN: 9783540001188
Category : Health & Fitness
Languages : en
Pages : 192
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Book Description
Plant protease inhibitors are diverse in number & specificity towards various proteolytic enzymes.
