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Author: Mohit Kumar
Publisher: Springer
ISBN: 9789819731107
Category : Science
Languages : en
Pages : 0
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Book Description
The book explains the use of natural products as scaffolds in tissue engineering. It presents an introduction to the concept of natural product-based scaffolds and explores various fabrication strategies for their synthesis. The book highlights the wide range of applications of these scaffolds in tissue engineering, including their use in tissue regeneration, wound healing, plastic surgery, and breast reconstruction. Specific natural products, such as gums (xanthan, gellan, arabic, guar, ghatti gum), chitosan, collagen are discussed in separate chapters. In addition, various application of natural product loaded PCL and PLA scaffolds have also been discussed. Each chapter focuses on the application of these natural product based scaffolds and explores their potential in tissue engineering. It also covers specific applications of these scaffolds in tissue regeneration, including angiogenesis, bone, skin, and nerve tissue regeneration. The book addresses important considerations regarding the toxicity and regulatory aspects of natural product-based scaffolds and explores the challenges associated with their implementation and emphasizes the need for safety and compliance in their use. Overall, the book provides a comprehensive overview of the field. It serves as a valuable resource for researchers, scientists, and professionals in the field of tissue engineering.
Author: Mohit Kumar
Publisher: Springer
ISBN: 9789819731107
Category : Science
Languages : en
Pages : 0
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Book Description
The book explains the use of natural products as scaffolds in tissue engineering. It presents an introduction to the concept of natural product-based scaffolds and explores various fabrication strategies for their synthesis. The book highlights the wide range of applications of these scaffolds in tissue engineering, including their use in tissue regeneration, wound healing, plastic surgery, and breast reconstruction. Specific natural products, such as gums (xanthan, gellan, arabic, guar, ghatti gum), chitosan, collagen are discussed in separate chapters. In addition, various application of natural product loaded PCL and PLA scaffolds have also been discussed. Each chapter focuses on the application of these natural product based scaffolds and explores their potential in tissue engineering. It also covers specific applications of these scaffolds in tissue regeneration, including angiogenesis, bone, skin, and nerve tissue regeneration. The book addresses important considerations regarding the toxicity and regulatory aspects of natural product-based scaffolds and explores the challenges associated with their implementation and emphasizes the need for safety and compliance in their use. Overall, the book provides a comprehensive overview of the field. It serves as a valuable resource for researchers, scientists, and professionals in the field of tissue engineering.
Author: Stefan Bräse
Publisher: Royal Society of Chemistry
ISBN: 1782620303
Category : Medical
Languages : en
Pages : 486
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Book Description
This book addresses the various classes of privileged scaffolds and covers the history of their discovery and use.
Author: Mohit Kumar
Publisher: Springer Nature
ISBN: 9819731119
Category :
Languages : en
Pages : 308
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Book Description
Author: Renato A. Bauer
Publisher:
ISBN:
Category :
Languages : en
Pages : 658
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Book Description
A major challenge to finding compounds that modulate protein function is the identification of chemical matter for screening. Although Nature provides excellent options for screening in the form of natural products, sufficient quantities can be difficult to obtain and characterize. Thus, chemical synthesis plays a lead role in providing molecules for screening, and chemists must ultimately decide what to synthesize based on the predicted value of the end products. We developed new synthetic strategies to access compounds for screening. In each case, natural products serve as an inspiration for the developed chemistry. First, a strategy was developed that provides access to scaffolds based on bioactive alkaloids and terpenoids. A key feature of this strategy is the use of transition metals to mediate the synthesis of multiple scaffolds from simple enynes and diynes. A t -butylsulfinamide group serves as a convenient tether to facilitate this chemistry. Principal component analysis (PCA) is used to analyze the relationship of our synthetic scaffolds to naturally occurring alkaloids and terpenoids. Then, a chemical reaction was studied that provides access to benzannulated medium rings inspired by natural products. In the developed reaction, three reagent classes (TsOH, Cu[BF 4 ] 2 , and Tf 2 0) were shown to polarize the carbonyl of a polycyclic cyclohexadienone and subsequently cause a cationic fragmentation reaction that generates an aromatic ring annulated to a medium ring. This process efficiently produces 7- to 11- membered rings while tolerating a variety of common functional groups. Work is presented on efforts to apply this reaction to the synthesis of two natural products, heliannuol A and puerol A.
Author: Alexander Hillisch
Publisher: Birkhäuser
ISBN: 3034879970
Category : Medical
Languages : en
Pages : 294
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Book Description
Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.
Author: Angelos Dimitrios Peroulias
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
This note is part of Quality testing.
Author: Roberto Todeschini
Publisher: John Wiley & Sons
ISBN: 9783527628773
Category : Science
Languages : en
Pages : 1257
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Book Description
The number-one reference on the topic now contains a wealth of new data: The entire relevant literature over the past six years has been painstakingly surveyed, resulting in hundreds of new descriptors being added to the list, and some 3,000 new references in the bibliography section. Volume 1 contains an alphabetical listing of more than 3300 descriptors and related terms for chemoinformatic analysis of chemical compound properties, while the second volume lists over 6,000 references selected from 450 journals. To make the data even more accessible, the introductory section has been completely re-written and now contains several "walk-through" reading lists of selected keywords for novice users.
Author: Nathan Brown
Publisher: John Wiley & Sons
ISBN: 3527665161
Category : Medical
Languages : en
Pages : 440
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Book Description
This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects. The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. Methods such as CATS, Feature Trees, Feature Point Pharmacophores (FEPOPS), and SkelGen are discussed among many others. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry. While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.
Author: Richard Firn
Publisher: Oxford University Press on Demand
ISBN: 0199566836
Category : Science
Languages : en
Pages : 261
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Book Description
This is the first monograph to describe Natural Products (NPs) as a group in an evolutionary context. It synthesizes a widely dispersed literature and provides a general picture of natural products encompassing evolution, history, ecology, and environmental issues, along with some deeper theory relevant to biochemistry.
Author: Jacob Peedicayil
Publisher: Academic Press
ISBN: 0128235780
Category : Science
Languages : en
Pages : 848
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Book Description
Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field
