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Author: Lucas de Freitas
Publisher:
ISBN:
Category : Electronic books
Languages : en
Pages : 0
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Book Description
Photodynamic therapy is a non-invasive option for eliminating superficial tumors and to control infections. However, despite some protocols are already approved for the clinic, PDT applications could be much broader if some of its main hindrances were overcome. For instance, the most efficient photosensitizers are hydrophobic, so if one injects them intravenously they tend to aggregate and to be internalized by phagocytes in the blood, impairing the delivery to the target site. In addition, visible light has a limited penetration in tissues, therefore the main applications of PDT are limited to superficial tumors unless an invasive procedure is used for the light to reach deeper sites. Another setback is the hypoxia that commonly happens in tumors, hindering the full potential of PDT as it depends on a constant oxygen supply. In this chapter the reader will find some strategies based on Nanotechnology to overcome these and other obstacles for PDT to reach its full clinical potential, i.e. hypoxia-reverting protocols, X-ray-driven PDT, Cherenkov radiation-driven PDT, and active tumor-targeting.
Author: Lucas de Freitas
Publisher:
ISBN:
Category : Electronic books
Languages : en
Pages : 0
Get Book Here
Book Description
Photodynamic therapy is a non-invasive option for eliminating superficial tumors and to control infections. However, despite some protocols are already approved for the clinic, PDT applications could be much broader if some of its main hindrances were overcome. For instance, the most efficient photosensitizers are hydrophobic, so if one injects them intravenously they tend to aggregate and to be internalized by phagocytes in the blood, impairing the delivery to the target site. In addition, visible light has a limited penetration in tissues, therefore the main applications of PDT are limited to superficial tumors unless an invasive procedure is used for the light to reach deeper sites. Another setback is the hypoxia that commonly happens in tumors, hindering the full potential of PDT as it depends on a constant oxygen supply. In this chapter the reader will find some strategies based on Nanotechnology to overcome these and other obstacles for PDT to reach its full clinical potential, i.e. hypoxia-reverting protocols, X-ray-driven PDT, Cherenkov radiation-driven PDT, and active tumor-targeting.
Author: Prashant Kesharwani
Publisher: Woodhead Publishing
ISBN: 0323903541
Category : Technology & Engineering
Languages : en
Pages : 570
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Book Description
Nanomaterials for Photodynamic Therapy takes a unique approach to this area, with a key focus on the use of nanomaterials and nanocarriers for photodynamic therapy (PDT). The book introduces the history and mechanism of action behind PDT, covering the variety of sensitizers currently available. Subsequent chapters review existing and emerging nanomaterials for PDT, including hydrogel nanocomposites, fullerenes, quantum dots, polymeric micelles, and more. Challenges and translational aspects of PDT are also discussed, touching on the issues and hindrances of drug resistant cancers.The book bridges the gap between the physics and clinical aspects of PDT, offering a unique nanomaterials-focused perspective. This book will prove useful for materials scientists, biomedical engineers, electrical and optical engineers, and pharmaceutical scientists interested in cancer treatment. Reviews a broad range of nanomaterials for PDT, such as graphene oxide, dendrimers, solid lipid nanoparticles, and more Provides a helpful introduction to the history and mechanism of action behind PDT Discusses challenges in clinical translational, particularly in drug-resistant cancers
Author: Manzar Abbas
Publisher: Elsevier
ISBN: 0323957595
Category : Technology & Engineering
Languages : en
Pages : 274
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Book Description
Organic Nanomaterials for Cancer Phototheranostics highlights the use of biocompatible building blocks to make nanomaterials that can aid in medical treatment through better diagnostic and antitumor efficacy. It synthesizes the current literature on synthetic strategies and designs based on peptides, proteins, polymers, lipids, and their conjugates, as well as composites and complexes with metals and inorganic components used to form the nanomaterials. Mechanistic approaches, clinical problems, and therapeutic and diagnostics mechanisms are covered in each chapter. Cellular interactions and uptake, pharmacokinetics, biodistribution, drug delivery efficiency, and safety concerns of these types of nanomaterials are discussed, as well. Other topics looked at include photostability, clearance, metabolism, in-vitro and in-vivo mechanisms, therapeutic efficacy, imaging, and toxicology. Outlines fabrication and design strategies of peptides, proteins, polymers, lipids, composites, and complexes with metals and inorganic components Discusses the limitations and challenges of organic nanomaterials in clinical use, including their mechanisms of penetration into cancer cells and tissue, photostability, clearance, and metabolism Covers clinical problems and therapeutic and diagnostics mechanisms
Author: Michael R. Hamblin
Publisher: Elsevier
ISBN: 1908818786
Category : Science
Languages : en
Pages : 573
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Book Description
Nanoscience has become one of the key growth areas in recent years. It can be integrated into imaging and therapy to increase the potential for novel applications in the field of photomedicine. In the past commercial applications of nanoscience have been limited to materials science research only, however, in recent years nanoparticles are rapidly being incorporated into industrial and consumer products. This is mainly due to the expansion of biomedical related research and the burgeoning field of nanomedicine. Applications of Nanoscience in Photomedicine covers a wide range of nanomaterials including nanoparticles used for drug delivery and other emerging fields such as optofluidics, imaging and SERS diagnostics. Introductory chapters are followed by a section largely concerned with imaging, and finally a section on nanoscience-enabled therapeutics. Covers a comprehensive up-to-date information on nanoscience Focuses on the combination of photomedicine with nanotechnology to enhance the diversity of applications Pioneers in the field have written their respective chapters Opens a plethora of possibilities for developing future nanomedicine Easy to understand and yet intensive coverage chapter by chapter
Author: Wansong Chen
Publisher: Frontiers Media SA
ISBN: 2889667766
Category : Science
Languages : en
Pages : 201
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Book Description
Author: Mingqian Tan
Publisher: World Scientific
ISBN: 9814635421
Category : Health & Fitness
Languages : en
Pages : 430
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Book Description
"Nanomaterials offer great potential for effective tumor diagnosis and therapy combing diagnostic agents and therapeutic drugs into one platform. In this book, the most recent progress of main nanomaterials and their applications in tumor targeting theranostics is presented. It summarizes the recent advances of current principal nanomaterials in tumor theranostics, including magnetic nanomaterials, quantum dots, mesoporous silica nanoparticles, gold nanomaterials, polymeric nanosystem, carbon nanomaterials, lipopolyplex nanoparticles, microbubbles, upconversion nanomaterials and dendrimers. It will enable readers to get a more realistic understanding of both the advantages and limitations of nanomaterials for potential tumor targeting theranosis. The publication of this book will accelerate the spread of ideas that are currently trickling through the scientific literature. Also a greater understanding of the potential and challenge of nanomaterials for tumor targeting theranostics is highly anticipated for practical clinical use."--Provided by publisher.
Author: Gil Gonçalves
Publisher: Springer
ISBN: 3319898787
Category : Technology & Engineering
Languages : en
Pages : 457
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Book Description
This book presents a systematic overview of the most relevant nanomaterials and their respective intrinsic properties that have been highly explored by the scientific community and pharmaceutical companies in several different modalities for cancer therapy and bioimaging. The chapters explore the synergistic effects provided by the different nanostructured materials and highlight the main in vitro and in vivo therapeutic achievements on cancer. This work also provides relevant discussion about the recent progresses and future challenges that nanotechnology faces on the conception of more efficient nanoformulations against primary tumors, circulating cancer cells and metastases.
Author: Nilesh M. Mahajan
Publisher: Elsevier
ISBN: 0323885683
Category : Business & Economics
Languages : en
Pages : 478
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Book Description
Photophysics and Nanophysics in Therapeutics explores the latest advances and applications of phototherapy and nanotherapy, covering the application of light, radiation, and nanotechnology in therapeutics, along with the fundamental principles of physics in these areas. Consisting of two parts, the book first features a range of chapters covering phototherapeutics, from the fundamentals of photodynamic therapy (PDT) to applications such as cancer treatment and advances in radiotherapy, applied physics in cancer radiotherapy treatment, and the role of carbon ion beam therapy. Other sections cover nanotherapeutics, potential applications and challenges, and nanotherapy for drug delivery to the brain. Final chapters delve into nanotechnology in the diagnosis and treatment of cancers, the role of nanocarriers for HIV treatment, nanoparticles for rheumatoid arthritis treatment, peptide functionalized nanomaterials as microbial sensors, and theranostic nanoagents. Evaluates the latest developments in the fields of phototherapy and nanotherapy Investigates the fundamental physics behind these technologies Explores therapeutic applications across a range of diseases, such as skin disorders, cancer, and neurological conditions Includes case studies that illustrate research in practice Considers challenges and future perspectives
Author: Fan Zhang
Publisher: Springer
ISBN: 3662455978
Category : Technology & Engineering
Languages : en
Pages : 428
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Book Description
This book introduces the latest advances made in both fundamental studies and potential applications of upconversion nanomaterials, particularly in the field of high-resolution in vitro bioanalysis and in vivo imaging. This book starts with the synthesis and characterization, and focuses on applications ranging from materials science to biology. Above all, it describes cutting-edge advances in upconversion nanophosphor (UCNP)-based applications in multiplexed encoding, guest delivery and release systems, photodynamic therapy (PDT), solar cells, photocatalysis and so on. The major barriers that currently prevent UCNPs from being used in mainstream applications are also presented in detail.
Author: Seok Ki Choi
Publisher: Elsevier
ISBN: 0128178418
Category : Technology & Engineering
Languages : en
Pages : 424
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Book Description
Photonanotechnology for Therapeutics and Imaging surveys major concepts and recent advances in the use of photonanotechnology with nanomaterials reported in various interdisciplinary fields, including chemistry, materials science, biomedical engineering and biomedicine. This book discusses the impact of this technology on the advancement of therapeutic modalities and imaging methods in cancers, infectious diseases and other serious diseases. Photonanotechnology studies the design principle, application and development of photoactive nanomaterials. It applies light-controlled strategies for the development of nanotherapeutics, imaging agents and diagnostic nanodevices. Provides the latest information on photocontrolled drug delivery systems Details how photoactive nanomaterials are designed to release reactive oxygen species (ROS) for photodynamic therapy (PDT) Explains how photoactive nanomaterials have the ability to induce surface plasmonic heating for photothermal therapeutic (PTT) effects
