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Author: Dipak K. Dube
Publisher: Springer Science & Business Media
ISBN: 9780817642266
Category : Science
Languages : en
Pages : 304
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Book Description
Myofibrillogenesis has been studied extensively over the last 100 years. Until recently, we have not had a comprehensive understanding of this fundamental process. The emergence of new technologies in molecular and cellular biology, combined with classical embryology, have started to unravel some of the complexities of myofibril assembly in striated muscles. In striated muscles, the contractile proteins are arranged in a highly ordered three dimensional lattice known as the sarcomere. The assembly of a myofibril involves the precise ordering of several proteins into a linear array of sarcomeres. Multiple isoforms in many of these proteins further complicate the process, making it difficult to define the precise role of each component. This volume has been compiled as a comprehensive reference on myofibrillogenesis. In addition, the book includes reviews on myofibrillar disarray under various pathological conditions, such as familial hypertrophic cardiomyopathy (FHC), and incorporates a section on the conduction system in the heart. Much of the information in this volume has not been described elsewhere. Presented in a manner to be of value to students and teachers alike, "Myofibrillogenesis" will be an invaluable reference source for all in the fields of muscle biology and heart development.
Author: Dipak K. Dube
Publisher: Springer Science & Business Media
ISBN: 9780817642266
Category : Science
Languages : en
Pages : 304
Get Book Here
Book Description
Myofibrillogenesis has been studied extensively over the last 100 years. Until recently, we have not had a comprehensive understanding of this fundamental process. The emergence of new technologies in molecular and cellular biology, combined with classical embryology, have started to unravel some of the complexities of myofibril assembly in striated muscles. In striated muscles, the contractile proteins are arranged in a highly ordered three dimensional lattice known as the sarcomere. The assembly of a myofibril involves the precise ordering of several proteins into a linear array of sarcomeres. Multiple isoforms in many of these proteins further complicate the process, making it difficult to define the precise role of each component. This volume has been compiled as a comprehensive reference on myofibrillogenesis. In addition, the book includes reviews on myofibrillar disarray under various pathological conditions, such as familial hypertrophic cardiomyopathy (FHC), and incorporates a section on the conduction system in the heart. Much of the information in this volume has not been described elsewhere. Presented in a manner to be of value to students and teachers alike, "Myofibrillogenesis" will be an invaluable reference source for all in the fields of muscle biology and heart development.
Author: Michael J. Alter
Publisher: Human Kinetics
ISBN: 9780736048989
Category : Health & Fitness
Languages : en
Pages : 382
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Book Description
Based on the latest research, this revised & updated edition includes detailed illustrations throughout & an expanded section of scholarly & professional references.
Author: H.L. Granzier
Publisher: Springer Science & Business Media
ISBN: 1461542677
Category : Science
Languages : en
Pages : 427
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Book Description
Elastic filaments refer mainly to titin, the largest of all known proteins. Titin was discovered initially in muscle cells, where it interconnects the thick filament with the Z-line. Titin forms a molecular spring that is responsible for maintaining the structural integrity of contracting muscle, ensuring efficient muscle contraction. More recently, it has become clear that titin is not restricted to muscle cells alone. For example, titin is found in chromosomes of neurons and also in blood platelets. This topic is fast becoming a focal point for research in understanding viscoelastic properties at the molecular, cellular, and tissue levels. In titin may lie a generic basis for biological viscoelasticity. It has become clear that titin may hold the key to certain clinical anomalies. For example, it is clear that titin-based ventricular stiffness is modulated by calcium and that titin is responsible for the altered stiffness in cardiomyopathies. It is also clear from evidence from a group of Finnish families that titin mutations may underlie some muscular dystrophies and that with other mutations chromatids fail to separate during mitosis. Thus, it is clear that this protein will have important clinical implications stemming from its biomechanical role. One aspect of this field is the bringing together of bioengineers with clinical researchers and biologists. Genetic and biochemical aspects of titin-related proteins are being studied together with front-line engineering approaches designed to measure the mechanics of titin either in small aggregates or in single molecules.
Author:
Publisher: Academic Press
ISBN: 0128033436
Category : Medical
Languages : en
Pages : 386
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Book Description
Zebrafish at the Interface of Development and Disease Research presents the latest on the shared pathways that govern development and contribute to disease. Zebrafish have traditionally been used to study vertebrate development, providing interesting data on the developmental processes and genes that are implicated in disease. This new release in the series contains informative discussions on congenital heart defects in zebrafish, the use of zebrafish in studying kidney development and disease, and muscle development, homeostasis and disease in zebrafish. Each chapter interweaves the study of zebrafish development and its application to the immune system, the kidney, liver, heart and others. - The subject matter is unique - no single volume has pulled together the theme of development and disease with zebrafish as a centerpiece - Leading experts in the field - all of them running zebrafish focused labs for each chapter
Author: Brigitte M. Jockusch
Publisher: Springer
ISBN: 3319463713
Category : Medical
Languages : en
Pages : 356
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Book Description
Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of intracellular motility, but also on its role in nuclear processes like chromatin architecture and transcription. Progress in understanding these different physiological phenomena, but also in unravelling the basis of actin-based pathophysiological processes has been made by combining video microscopy, molecular biology, genetics and biochemistry. Thus, the current research on actin, as ongoing in many international laboratories, is a "hot spot" in basic and translational research in life sciences. In this book on "The Actin Cytoskeleton", twelve internationally renowned authors present specific chapters that cover their recent work concerned with the various roles of actin mentioned above. This comprehensive volume is therefore an attractive handbook for teachers and students in many fields of medicine and pharmacology.
Author:
Publisher: Elsevier
ISBN: 008046002X
Category : Science
Languages : en
Pages : 404
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Book Description
Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology. Volume 68, the most recent publication in Current Topics in Developmental Biology, not only discusses the most up-to-date discoveries, it includes 46 figures and 7 tables, all in full color. This volume touches upon topics such as Prolactin and Growth Hormone Signaling; Corpus Luteum Development: Lessons from Genetic Models in Mice; Comparative Developmental Biology of the Mammalian Uterus; Sarcopenia of Aging and its Metabolic Impact; and even a chapter on Initial failure in Myoblast Transplantation Therapy has led the way towards the isolation of muscle stem cells: Potential for tissue regeneration.* Most recent volume series that offers 11 chapters of the latest studies of developmental biology* Discusses various subjects such as tissue regeneration, the role of proteins, and a comparative analysis of the mammalian uterus* Full color figures and tables with detailed illustrations
Author:
Publisher: Academic Press
ISBN: 0080586503
Category : Science
Languages : en
Pages : 347
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Book Description
International Review of Cytology
Author: Chandrasekharan C. Kartha
Publisher: Springer Nature
ISBN: 3030855368
Category : Science
Languages : en
Pages : 356
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Book Description
This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon.
Author: Francesco Moccia
Publisher: MDPI
ISBN: 3038975370
Category : Medical
Languages : en
Pages : 463
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Book Description
This book is a printed edition of the Special Issue "Calcium Signaling in Human Health and Diseases" that was published in IJMS
Author: Robert J. Tomanek
Publisher: Springer Science & Business Media
ISBN: 1461202078
Category : Science
Languages : en
Pages : 290
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Book Description
The `Formation of the Heart and its Regulation` reviews in considerable detail the major events in heart development and their control via genes, cell-cell interactions, growth factors and other contributing elements. In addition, there is an extensive and useful overview of the field of heart development taken as a whole. The book will appeal to all students and researchers working on cardiovascular development and to pediatric cardiologists.
