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Multiple Testing Procedures with Applications to Genomics

Multiple Testing Procedures with Applications to Genomics PDF Author: Sandrine Dudoit
Publisher: Springer
ISBN: 9781441923790
Category : Science
Languages : en
Pages : 0

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Book Description
This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.