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Author: Hiroshi Kiyono
Publisher: Elsevier
ISBN: 0080537057
Category : Medical
Languages : en
Pages : 501
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Book Description
This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. Provides the latest views on mucosal vaccines Applies basic principles to the development of new vaccines Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases Unique and user-friendly organization
Author: Hiroshi Kiyono
Publisher: Elsevier
ISBN: 0080537057
Category : Medical
Languages : en
Pages : 501
Get Book Here
Book Description
This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. Provides the latest views on mucosal vaccines Applies basic principles to the development of new vaccines Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases Unique and user-friendly organization
Author: Pamela A. Kozlowski
Publisher: Springer Science & Business Media
ISBN: 3642236936
Category : Medical
Languages : en
Pages : 204
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Book Description
This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.
Author: David W. Pascual
Publisher: Academic Press
ISBN: 012811925X
Category : Medical
Languages : en
Pages : 941
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Book Description
Mucosal Vaccines: Innovation for Preventing Infectious Diseases discusses basic knowledge and discovery in the area of mucosal immunology and its related scientific fields. This completely updated, revised and authoritative treatise covers all aspects of mucosal vaccines, including their development, mechanisms of action, molecular/cellular aspects and practical applications. The book is organized in a unique format with basic, clinical and practical aspects described and discussed. The accumulated knowledge and new discoveries on the development of mucosal vaccines are logically introduced and discussed in an easy-to-understand format. Provides the latest views on mucosal vaccines Applies basic and current principles in the field of mucosal immunology and related scientific fields (e.g., microbiology, infectious diseases, systems biology, medicine, dentistry, veterinary medicine and translational research) to the development of new vaccines Links basic, clinical and practical aspects of mucosal vaccines to different infectious diseases Presents user-friendly organization using attractive illustrations
Author: Virgil Schijns
Publisher: Elsevier
ISBN: 0080457215
Category : Medical
Languages : en
Pages : 396
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Book Description
Immunopotentiators in Modern Vaccines provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations. Contributions from leading international authorities in the field Well-illustrated, informative figures present the interactions between immunopotentiators and the host immune system Each chapter lists advantages and potential hurdles for achieving a practical application for the specific immunopentiator
Author: Benjamin H. Beck
Publisher: Academic Press
ISBN: 0124171931
Category : Technology & Engineering
Languages : en
Pages : 410
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Book Description
Mucosal Health in Aquaculture is an essential reference on mucosal health for the diverse aquaculture community. Rich in explanatory figures and schematics, the book includes important concepts such as structural and cellular composition of mucosal surfaces in fish and shellfish, known functional roles of molecular and cellular actors during pathogen invasion, impacts of nutrition on the mucosal barriers, impacts of chemical treatments on mucosal surfaces, mucosal vaccines and vaccination strategies, and more. The health of cultured aquaculture species is critical in establishing the sustainable growth of the aquaculture industry worldwide, and mucosal health is of particular interest to those working in aquaculture because mucosal surfaces (skin, gill, intestine, reproductive tissues) constitute the first line of defense against pathogen invasion. Mucosal Health in Aquaculture captures the latest research on mucosal barriers in aquaculture species and their impacts on nutrition and immunity to ensure sustainable aquaculture development. Includes research case studies to exhibit the importance of various integrated approaches to mucosal health Examines the latest scientific methods and technologies to maximize efficiencies for healthy fish production for farming Brings together the latest knowledge and research on mucosal barriers and mechanisms from world-wide experts in mucosal health Utilizes detailed diagrams and figures to enhance comprehension
Author: Pamela A. Kozlowski
Publisher: Springer
ISBN: 9783642236945
Category : Medical
Languages : en
Pages : 198
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Book Description
This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.
Author: Phillip Smith
Publisher: Garland Science
ISBN: 1000754499
Category : Medical
Languages : en
Pages : 615
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Book Description
This respected graduate-level textbook provides comprehensive and accessible coverage of the basic and clinical aspects of the mucosal immune system, addressing the major components of the mucosal barrier ̶ gastrointestinal, upper and lower respiratory, ocular, and genitourinary mucosal immune systems ̶ in a highly user-friendly style. The editors of and contributors to the book, all internationally-recognized leaders, present the current principles, concepts, and basic processes involved in mucosal immunology, mucosal diseases, and host defense at mucosal surfaces. Topics discussed include the development and structure of the mucosal immune system and its cellular constituents, host-microbe relationships, infection, mucosal diseases, and vaccines. The second edition has been carefully updated throughout to reflect the latest developments from clinical research and key literature has been fully updated.
Author: Sergio Rosales-Mendoza
Publisher: Springer Nature
ISBN: 3030316688
Category : Technology & Engineering
Languages : en
Pages : 343
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Book Description
This book provides a compilation of the current developments in mucosal nanovaccines, which are an attractive approach to fight against infectious and non-communicable diseases. Since nanomaterials possess unique properties; many of them have a positive effect on vaccine efficacy when used as antigen carriers and have been applied in vaccinology with significant advances over the past years. This book addresses the methodologies for mucosal nanovaccines synthesis; based on the following nanomaterials: gold, PLGA, silica, and chitosan nanoparticles; as well as nanogels, carbon nanotubes, liposomes, and Virus-like particles. A description of the immunogenic properties of the mucosal nanovaccines is presented, highlighting the improvements achieved with this approach when compared to conventional formulations. Mucosal vaccines constitute the most practical immunization approach since they are easy to administer (promoting patient ́s comfort and increasing compliance), allow triggering relevant immune responses at both the site of administration and distant compartments, and thus may protect the main entry portal for pathogens (oral, nasal, and genital mucosae). In this context, the potential of nanovaccines to result in new mucosal formulations in the benefit of global health is analyzed. Covers the synthesis and functionalization of nanomaterials for the development of nanovaccines; Discusses the underlying mechanisms involved in the induction of immune responses through mucosal compartments and the advantages of nanomaterials in the formulation of nanovaccines; Transmits the state of the art for the development of mucosal nanovaccines; Provides routes for the design and evaluation of mucosal nanovaccines; Presents key perspectives for the field of mucosal vaccine development.
Author: W. John W. Morrow
Publisher: John Wiley & Sons
ISBN: 1118345347
Category : Medical
Languages : en
Pages : 552
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Book Description
Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application Includes evaluation of vaccine efficacy and safety Details clinical trial design, including regulatory requirements Discusses the emerging field of active cellular immunotherapy Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.
Author: Jean-Pierre Kraehenbuhl
Publisher: Springer Science & Business Media
ISBN: 3642599516
Category : Medical
Languages : en
Pages : 300
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Book Description
Mucosal immunity encompasses a broad field of research that includes areas of epithelial cell and molecular biology, molecular and cellular immunology, microbiology, virology, and vaccinology. This volume presents up to date and concise discussions of concepts as well as recent advances. It provides an overview of the components of the mucosal immune system, and the basic science relevant to mucosal vaccination. The authors assess current research in critical areas including: Organization of mucosal lymphoid tissue; antigen sampling and presentation in mucosal tissues; mucosalimmune responses and tolerance; immune effectors at mucosal sites; microbial-host interactions at mucosal sites; mucosal vaccines and adjuvants. This multi-disciplinary effort will be a valuable resource for researchers, clinicians and students who need a clear understanding of concepts and a guide to the wide-ranging literature in this very active research area.
