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Author: Fabien Marchand
Publisher: Frontiers Media SA
ISBN: 2832502555
Category : Science
Languages : en
Pages : 207
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Author: Fabien Marchand
Publisher: Frontiers Media SA
ISBN: 2832502555
Category : Science
Languages : en
Pages : 207
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Book Description
Author: Donald Iain MacDonald
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Wuping Sun
Publisher: Frontiers Media SA
ISBN: 2889744663
Category : Science
Languages : en
Pages : 141
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Author: Ilia V. Rogachevskii
Publisher: Frontiers in Pain Science
ISBN: 9781608059317
Category : Medical
Languages : en
Pages : 212
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Book Description
The monograph is a summary of methods used to study pain receptors and the results obtained in some experiments designed to study the effect of non-opioid analgesics. The molecular mechanisms of nociceptive information control in primary sensory nociceptive neurons are described based on investigations of the membrane signaling cascade (opioid-like receptor ? Na+,K+-ATPase ? NaV1.8 channel) observed by the authors. Based on this data, the authors conclude that the modulation of NaV1.8 channels responsible for the coding of noxious signals can be carried out due to two novel targeting mechanisms. The first of these is the activation of opioid-like receptors; the second is the activation of Na+/K+-ATPase as a signal transducer. The development of a novel class of analgesics that trigger these mechanisms should lead to a successful solution to the problem of chronic pain relief.Chapters of the monograph cover the general methods used in studying nociceptive pain (including the patch-clamp method), and the mechanism behind the binding of different ligands to these receptors such gamma-pyrones, gamma-pyridines and cardiotonic steroids.This monograph is a valuable reference for neuroscientists, pharmacologists and allied researchers studying pain receptors for the development of safe and effective analgesics.
Author: Raymond S. Sinatra
Publisher: Cambridge University Press
ISBN: 0521874912
Category : Medical
Languages : en
Pages : 729
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Book Description
This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Author: Howard L. Fields
Publisher: Elsevier Publishing Company
ISBN: 9780444809841
Category : Medical
Languages : en
Pages : 454
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Book Description
This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.
Author: Joyce A. De Leo
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 464
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Book Description
"Review of immune and glial factors within the peripheral and central nervous systems that relate to chronic pain states. Discussion of novel immune and glial targets for clinical pain control that may yield new analgesic drugs"--Provided by publisher.
Author: Wolfgang B. Liedtke, MD, PH.D.
Publisher: CRC Press
ISBN: 1420005847
Category : Medical
Languages : en
Pages : 502
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Book Description
Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Author: Melanie Rose Chin
Publisher:
ISBN:
Category : Drosophila
Languages : en
Pages : 0
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Book Description
In order to survive, an organism must be able to sense its surroundings. One particularly important sense is the processes of nociception, the ability to detect noxious stimuli. In Drosophila, when a noxious stimulus is sensed, larvae will perform a distinct rolling behavior. It is valuable to investigate the molecular mechanisms that give rise to the Drosophila larva's ability to sense noxious stimuli and to produce nociceptive rolling behavior as this will allow for a greater understanding of the nociceptive neural circuit and further insight into sensory perception. With the strong homology between Drosophila genes and human genes, these studies could find new targets for pain management. The initial focus of this dissertation was the gene defective proboscis extension response 11 (dpr11). dpr11 is a member of the immunoglobulin superfamily of proteins and it is part of a recently discovered protein network, the Dprome. It was my hypothesis that Dpr11 acts at synapses of nociceptor neurons to direct the formation of connections to downstream secondary neurons. While dpr11 was not found necessary for nociceptive behavior in Drosophila, gene expression studies supported the hypothesis that dpr11 and its binding partners DIP-gamma and DIP-beta are expressed in the nociception circuit. Importantly, dpr11-RNAi tests confirmed an off-target effect on another gene paralytic. Paralytic codes for the only voltage-gated sodium channel in Drosophila, and it is highly processed with many alternative transcripts. This study presents evidence that there are novel isoforms of para that may have a role in thermal nociception. This is a unique finding that relates to pain mechanisms in vertebrates as para is homologous to human voltage-gated sodium channels that are implicated in pain processing. This dissertation will also touch on TRP channels involved in sensory processing, including a mechanotransduction channel nompC and dTRPA1, the Drosophila homolog of human TRPA1. Data present a model for a novel role for nompC in the glia of the Drosophila larval brain, and information on the regulation of dTRPA1 in Drosophila nociceptive neurons. In summary, this dissertation broadly investigates the genetics behind neural circuit formation and sensory transduction processes, lending insight into how genes contribute to behavior and adding important information to the field of pain processing.
Author: Karla P. Zeitz
Publisher:
ISBN:
Category :
Languages : en
Pages : 308
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Book Description
