Molecular Mechanisms and Therapies of Colorectal Cancer PDF Download
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Author: Donatella Delle Cave
Publisher:
ISBN: 9783036565460
Category : Rectum
Languages : en
Pages : 0
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Book Description
Author: Donatella Delle Cave
Publisher:
ISBN: 9783036565460
Category : Rectum
Languages : en
Pages : 0
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Book Description
Author: Donatella Delle Cave
Publisher:
ISBN: 9783725809516
Category : Medical
Languages : en
Pages : 0
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Book Description
Colorectal cancer (CRC) is currently the third leading cause of cancer-related mortality. Transforming growth factor beta (TGF-β) signaling has been associated with CRC growth and metastasis due to its involvement in proliferation, epithelial-to-mesenchymal transition (EMT), and angiogenesis. The TGF-β superfamily contains over forty members, including TGF-βs, Nodal, Activin, and bone morphogenetic proteins (BMPs). Three types of TGF-β receptors (TGFβRs) have been identified: types 1, 2, and 3. After ligand binding, TGF-βR2 recruits and phosphorylates TGF-βR1, which, in turn, phosphorylates downstream SMAD (small mother against decapentaplegic) proteins. Phosphorylated SMAD4 translocates into the nucleus, where it activates the transcription of numerous target genes (including SERPINE1, LTBP2, CDKN1A, ARID3B, ATXN1, PTPRK, RAB6A, SMAD7, EHBP1, etc.), acting predominantly as a tumor suppressor gene. Interestingly, alterations in SMAD4 are frequent in metastatic CRC and, together with TGF-βR2 gene mutations, have been reported as late events able to promote CRC progression. The study of the TGF-β pathway in metastatic CRC is challenging because of the great genetic heterogeneity of CRC. However, the increasing availability of targeted and whole-exome DNA sequencing techniques makes it possible to identify genetic mutations in complex, dynamic, and heterogeneous clinical contexts and make correlations with clinical outcomes.
Author: Shilpa S. Dhar
Publisher: Frontiers Media SA
ISBN: 2832506410
Category : Medical
Languages : en
Pages : 201
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Book Description
Author: Chi Hin Cho
Publisher: Academic Press
ISBN: 0128199385
Category : Science
Languages : en
Pages : 242
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Book Description
Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer. Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding Updates current trends in the field with pioneering information on drug resistance Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view
Author: Ruowen Zhang
Publisher: Frontiers Media SA
ISBN: 2889743977
Category : Medical
Languages : en
Pages : 512
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Book Description
Author: Georg F. Weber
Publisher: Springer Science & Business Media
ISBN: 1402060165
Category : Medical
Languages : en
Pages : 643
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Book Description
This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers.
Author: American Institute for Cancer Resea
Publisher: Springer Science & Business Media
ISBN: 1461541492
Category : Medical
Languages : en
Pages : 169
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Book Description
The Eighth Annual Research Conference of the American Institute for Cancer Research, held in Washington, D.C., September 3-4, 1998, was on the subject "Colon Cancer Prevention: Dietary Modulation of Cellular and Molecular Mechanisms," with participants representing various disciplines interested in this area. One of the speak ers provided an appropriate quote from 17th century physician Thomas Adams: "Pre vention is better than healing because it saves the labor of being sick," which aptly describes the need for the prevention of cancer. An overview of normal and abnormal colonic development emphasized that although the typical human colon undergoes 1013 cell divisions by age 60, with the asso ciated possibilities for error, relatively few colon tumors develop. Since dietary modu lation leads to extremely small changes in colonic cells over a long period, animal models are useful to time, observe, and delineate the events associated with colon cancer. In the development colon cancer, the inactivation of the adenomatous polyposis coli (Apc) gene is one of the earliest known events. Normally Apc downregulates the cellular protein beta-catenin, but this is lost during cancer development. Beta-catenin may itself be an oncogene; it has a short half-life, but it is stabilized by binding to is more prevalent in the cell nucleus, the gene shuttles caherin. Although the Apc between the nucleus and the cytoplasm.
Author: Sayali Mukherjee
Publisher: CRC Press
ISBN: 1351166549
Category : Medical
Languages : en
Pages : 662
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Book Description
This volume presents a snapshot of some of the most important ongoing research in cancer. With cancer as the second leading cause of death worldwide, extensive research is going on globally to decipher the molecular mechanism underlying cancer that will help in finding better targets for drug therapy. The book brings together new research on molecular mechanism and cancer therapeutics in one place. With chapters from experts in their respective fields, chapters cover molecular mechanisms, etiology, prognosis, detection, and treatment of cancer. Emphasis has been given to the intricate mechanism behind the deregulation of cell division, disruption of cell cycle check points, mutation in oncogenes and tumor suppressor genes, apoptosis, and erratic cell signaling. The book discusses in detail topics such as angiogenesis and tumor microenvironment, which are increasingly receiving attention, especially in the field of neoplastic vascularization and metastasis. The book also includes chapters detailing the current understanding and the future perspective of cancer stem cells.
Author: Jean-François Beaulieu
Publisher: Humana
ISBN: 9781493992782
Category : Medical
Languages : en
Pages : 353
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Book Description
This volume explores the latest developments in the study of the mechanisms, diagnostics, screening methods, and therapeutics of colorectal cancer. The book’s chapters are divided into three parts: the chapters in Part One examine techniques used to study the molecular mechanisms in colorectal cancer development and progression. Part Two focuses on the innovative tools used to diagnose and detect cancer lesions in the early stages of cancer. Finally, Part Three discusses recent advancements in treating colorectal tumors and identifying new therapeutic molecules for treatment. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Colorectal Cancer: Methods and Protocols is a valuable resource for any scientist and researcher interested in this field of study.
Author: W. Schmiegel
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 318
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Book Description
Colorectal cancer is one of the most common causes of tumour-associated death in Western countries, and its incidence has been increasing in recent decades. The most important determinant for the course of the disease is tumour stage at the time of diagnosis. The detection of molecular changes in tumour tissue and in benign adenomatous polyps has improved our knowledge of colorectal carcinogenesis. Diseases with a high risk for malignant transformation, as well as family predisposition as an independent risk factor, have been identified. Furthermore, dietary and environmental factors, together with the intake of aspirin and other NSAIDs, influence tumor development. This implies new ways of specific testing for early diagnosis and new prevention strategies based on endoscopy and drug therapy. The main topics of this book, the proceedings of the international Falk Symposium No. 109, held in Titisee, Germany, on October 14-15, 1998, are molecular mechanisms, premalignant state and prevention. State-of-the-art chapters deliver the latest scientific developments on every topic, followed by more detailed chapters on specific items.
