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Author: Jack Silver
Publisher: CRC Press
ISBN: 9780849347856
Category : Science
Languages : en
Pages : 282
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Book Description
This publication covers the recent veritable explosion in knowledge regarding the genetic organization, structure, and function of the HLA class II region. It deals with the nature of diversity of HLA class II alleles, the molecular basis of this diversity, and the mechanisms by which HLA class II expression is regulated. Also addressed is the relationship of class II polymorphism to susceptibility to autoimmune diseases such as rheumatoid arthritis, insulin dependent diabetes mellitus, and pemphigus vulgaris. The book presents information on allele specific oligonucleotide (ASO) probes and their use in identifying susceptible individuals. It includes chapters which describe how cells transfected with HLA class II genes can be used for functional analysis. An appendix representing a compilation of all the known DR?? DQ?, DQ? sequences is included. This serves as an excellent source of comparison of newly derived sequences. This publication provides information on the enormous progress in the HLA field. It is intended for both the established investigator and the beginner.
Author: Jack Silver
Publisher: CRC Press
ISBN: 9780849347856
Category : Science
Languages : en
Pages : 282
Get Book Here
Book Description
This publication covers the recent veritable explosion in knowledge regarding the genetic organization, structure, and function of the HLA class II region. It deals with the nature of diversity of HLA class II alleles, the molecular basis of this diversity, and the mechanisms by which HLA class II expression is regulated. Also addressed is the relationship of class II polymorphism to susceptibility to autoimmune diseases such as rheumatoid arthritis, insulin dependent diabetes mellitus, and pemphigus vulgaris. The book presents information on allele specific oligonucleotide (ASO) probes and their use in identifying susceptible individuals. It includes chapters which describe how cells transfected with HLA class II genes can be used for functional analysis. An appendix representing a compilation of all the known DR?? DQ?, DQ? sequences is included. This serves as an excellent source of comparison of newly derived sequences. This publication provides information on the enormous progress in the HLA field. It is intended for both the established investigator and the beginner.
Author: Michael J. Browning
Publisher: Taylor & Francis
ISBN:
Category : Medical
Languages : en
Pages : 472
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Book Description
This is a review of the major histocompatibility complex (MHC), and the role it plays in the immune response and in disease. The emphasis throughout is on the human MHC, but relevant animal studies are inclded to give a comprehensive review of the subject.
Author: Bjarte G. Solheim
Publisher: Springer Science & Business Media
ISBN: 3642703674
Category : Medical
Languages : en
Pages : 646
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Book Description
This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses. Trans plantation antigens were discovered and characterized by Gorer about 50 years ago, and the biological basis for the unequalled complexity of their variability between individuals within a species, in spite of extreme conservation between species, was the subject of intense research and discussion for many years. During the days of belief in "immune surveillance" against spontaneously developing tumors, it was suggested that histoincompatibility between members of one species would prevent cancer from being a contagious disease and thus a threat to the species. Immunologists involved in human transplantation had to learn and care about the complexity, especially after 1967, when it was found that HLA antigens were the products of the human MHC. Rejection of HLA-identical sib kidney grafts was so rare, even in those days, that cases of rejection were described in scientific papers.
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Sebastian Boegel
Publisher: Springer Nature
ISBN: 1071638742
Category :
Languages : en
Pages : 300
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Book Description
Author: Bo Dupont
Publisher: Springer
ISBN: 3662399466
Category : Medical
Languages : en
Pages : 636
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Book Description
This set reports the results of the 10th International Histocompatibility Workshop, in which 362 laboratories collaborated over a three year period in research projects on the classification of HLA genes and their products. Volume 1 describes the experimental design of the workshop studies and their results. Volume 2 is a collection of papers on the latest developments in the molecular biology of HLA systems. Immunobiology of HLA is a valuable reference for tissue typing laboratories, blood banks, and general research programs on HLA and related diseases because it identifies common sources of HLA genes and gene products to be used as reference reagents, and because it is the only complete compilation of the latest research and results in the field.
Author: Antoine Blancher
Publisher: Springer Science & Business Media
ISBN: 3642590861
Category : Medical
Languages : en
Pages : 578
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Book Description
Zoologists have categorized primates into a single order, and no one doubts today that they share a common ancestry. Humans and Old and New World non human primate species, from the lemurs of Madagascar to the African anthro poid apes, represent diverging branches of an evolutionary common trunk. Along with species-specific characters, all primates have retained a number of ancestral traits, relics of their common origin. The comparative study of these species-specific and ancestral traits makes it possible to reconstruct the evolu tionary pathways of humans and nonhuman primates. The discovery of the human blood groups and, later, of the Major Histocom patibility Complex (MHC) had a seminal effect on the field of human genetics, providing the first sound examples of mendel ian polymorphisms. The use of blood group and MHC alleles as genetic markers in biological anthropology gen erated a conceptual revolution and persuaded researchers to begin to think in terms of populations and not only intems of typology. The counterparts of these human red and white cell antigens were found and studied in nunhuman primates, and progress in this field is summarized in this book.
Author: Narinder K Mehra
Publisher: Boydell & Brewer Ltd
ISBN: 9788184488708
Category : Medical
Languages : en
Pages : 616
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Book Description
A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.
Author: John Lee
Publisher: Springer
ISBN: 9781461280187
Category : Medical
Languages : en
Pages : 0
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Book Description
This volume documents our growing understanding of the human major histocompatibility complex. The application of this information is ever more important as the limits of transplantation continue to be reduced, including the recent success of bone marrow transplantation between unrelated but closely matched individuals. In addition, the need to transfuse platelets in the face of immunologic barriers continues to challenge transfusion services. Thus, the serologic information summarized in this volume is essential for optimal patient care. At the same time, recombinant DNA technology has led to a revolution in our understanding of many aspects of basic biology. Among the advances has been the initial characterization of the structure of some HLA loci. While this will ultimately improve clinical services, constant reference to serologic data is essential so that the powerful new techniques can be applied in the most effective ways. The timing of the First Red Cross International Histocompatibility Workshop is fortunate as it brings together experts from around the world to address the state of the art. We are all grateful to Dr. John Lee and his colleagues for organizing the workshop, and for bringing together in this volume the material to be presented in Beijing during October 17-23, 1990. Leon W. Hoyer, M.D.
Author: Bjarte G. Solheim
Publisher: Springer Science & Business Media
ISBN: 3642775063
Category : Medical
Languages : en
Pages : 431
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Book Description
With this book we· want to address young graduate students, clini cians involved in transplantation, and technicians in transplantation immunology laboratories. The volume should give a comprehensive but basic, up to date introduction to the structure, function, and clinical importance of the HLA system. We believe that there is a need for such a survey, and think that the present level of our knowledge is an optimal occasion for publication. A significant number of ques tions have now been resolved, and our knowledge has reached a level of sophistication that provides the basis for additional questions and answers. Although the emphasis of this book is on the role of HLA anti gens in clinical transplantation, their involvement in other clinical contexts is also discussed. The main focus is on the human MHC an tigenic system, but MHC systems in other species are described as they contribute to our understanding of the structural and functional characteristics of HLA antigens. Some important issues related to laboratory techniques are also covered. The contributors have a close affiliation to the field of transplan tation immunology. A majority have even been playing important roles in unraveling the HLA system and its functions. We believe this has contributed significantly to the quality and clinical and practical relevance of the book. As editors, we drew up the principal guidelines and took care that the chapters can be read as separate entities, although this invariably results in some overlapping.
