Molecular Basis of Lymphokine Action

Molecular Basis of Lymphokine Action PDF Author: David R. Webb
Publisher: Springer Science & Business Media
ISBN: 1461245982
Category : Medical
Languages : en
Pages : 495

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Book Description
The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth odology were the B-cell growth and differentiation factors, in partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor.

Molecular Basis of Lymphokine Action

Molecular Basis of Lymphokine Action PDF Author: David R. Webb
Publisher: Springer Science & Business Media
ISBN: 1461245982
Category : Medical
Languages : en
Pages : 495

Get Book Here

Book Description
The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth odology were the B-cell growth and differentiation factors, in partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor.

Molecular Basis of Lymphokine Action

Molecular Basis of Lymphokine Action PDF Author: David R. Webb
Publisher: Humana Press
ISBN: 9781461289432
Category : Medical
Languages : en
Pages : 482

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Book Description
The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth odology were the B-cell growth and differentiation factors, in partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor.

Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation

Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation PDF Author: Heinz Lother
Publisher: Springer Science & Business Media
ISBN: 3642741975
Category : Medical
Languages : en
Pages : 464

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Book Description
Proceedings of the NATO Advanced Research Workshop on Vectors for Transfer and Expression of Genes held in Wilsede, FRG, October 21-24, 1988 on the Occasion of the 40th Anniversary of the Heinrich-Pette-Institut fürExperimentelle Virologie u. Immunologie an der Univ. Hamburg

Current Catalog

Current Catalog PDF Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1060

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Book Description
First multi-year cumulation covers six years: 1965-70.

Macromolecular Biorecognition

Macromolecular Biorecognition PDF Author: Irwin Chaiken
Publisher: Springer Science & Business Media
ISBN: 1461246008
Category : Science
Languages : en
Pages : 359

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Book Description


The Role of Lymphokines in the Immune Response

The Role of Lymphokines in the Immune Response PDF Author: Stanley Cohen
Publisher: CRC Press
ISBN: 9780849364273
Category : Medical
Languages : en
Pages : 292

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Book Description
This book provides a broad overview of all aspects of modern lymphokine research. It begins with the ways in which lymphokines play a role in the activation of the immune response and concludes with their participation in various facets of host defense. It devotes special attention to structure, mechanism of action, and range application. In addition, this fascinating work also shows how lymphokines are involved in other physiologic responses, such as reparative reactions involving fibrosis and angiogenesis. This is an excellent resource for students and investigators in the biomedical sciences, as well as clinicians who require up-to-date information about our current understanding of immune processes.

Advances in Immunopharmacology

Advances in Immunopharmacology PDF Author: J. W. Hadden
Publisher: Elsevier
ISBN: 1483286827
Category : Medical
Languages : en
Pages : 337

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Book Description
The Fourth International Conference on Immunopharmacology took place in Osaka, Japan, May 1988. It was attended by over 900 participants from a variety of fields, illustrating the broad interest and wide-ranging applications of the subject. This Proceedings volume provides a comprehensive record of the Conference and is organized according to the sectional headings employed at the meeting. The topics covered include basic and clinical immunology, and preclinical and clinical aspects of immunopharmacology. The material presented is referenced and indexed throughout, and illustrated with photographs, diagrams and tables.

Handbook for Program Administrators

Handbook for Program Administrators PDF Author: National Heart, Lung, and Blood Institute. Office of Policy and Procedure
Publisher:
ISBN:
Category : Federal aid to medical research
Languages : en
Pages : 432

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Book Description


National Library of Medicine Current Catalog

National Library of Medicine Current Catalog PDF Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1068

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Book Description


Interleukin 3

Interleukin 3 PDF Author: John W. Schrader
Publisher: Academic Press
ISBN: 1483268160
Category : Medical
Languages : en
Pages : 445

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Book Description
Interleukin 3: The Panspecific Hemopoietin contains contributions from immunologists, hematologists, protein chemists, and molecular biologists whose efforts have defined the biology and molecular nature of interleukin 3 (IL-3) in less than a decade. The articles represent personal perspectives rather than exhaustive reviews. They are arranged in alphabetical order rather than thematically because many of the individual articles cover multiple aspects of the molecule. These articles cover topics such as the potential role of IL-3 in the pathology of allergic and inflammatory disease and the role of IL-3 in the genesis of certain myeloid leukemias. A number of articles also highlight an important technical point, namely, that many of the various assays often used for IL-3 are not specific. One article indicates that the ""histamine-producing cell-stimulating factor"" activity can be mediated not only by IL-3 but also by granulocyte-macrophage colony-stimulating factor. Another deals with the lack of specificity of assays based on the induction of 20a-SDH or factor-dependent cell lines.