Molecular Analysis of the Nucleoprotein, Phosphoprotein, and Matrix Genes of the Hamster Neurotropic Strain of Measles Virus PDF Download
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Author: John Anthony Vanchiere
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: John Anthony Vanchiere
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Sonia Longhi
Publisher: Nova Publishers
ISBN: 9781600216299
Category : Medical
Languages : en
Pages : 180
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Book Description
Measles virus possesses a non segmented, single stranded, negative sense RNA genome that is encapsidated by the nucleoprotein to form a helical nucleocapsid. This ribonucleoproteic complex is the substrate for both transcription and replication. The RNA-dependent RNA polymerase binds to the nucleocapsid template via its co-factor, the phosphoprotein. This book focuses on the main structural information available on the nucleoprotein, showing that it consists of a structured core (NCORE) and of an intrinsically disordered C-terminal domain (NTAIL). The functional implications of the disordered nature of NTAIL are discussed in light of the ability of disordered regions to establish interactions with multiple partners, thus leading to multiple biological effects. Indeed, beyond the phosphoprotein, NTAIL also interacts with cellular partners, including the major heat shock protein, hsp72, the interferon regulator factor 3, IRF3, and a yet unidentified cellular receptor referred to as NR. This book consists of two chapters devoted to the general functions of the nucleoprotein in transcription and replication and to a detailed overview of its structural properties, and of three chapters focused on the functional relevance of the interaction between NTAIL and its various intracellular and extracellular partners.
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Category : Dissertations, Academic
Languages : en
Pages : 1006
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Author:
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ISBN:
Category : Dissertation abstracts
Languages : en
Pages : 896
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Author:
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ISBN:
Category : Medicine
Languages : en
Pages : 1592
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Author: Stewart Hal
Publisher: Elsevier
ISBN: 0323147461
Category : Medical
Languages : en
Pages : 515
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Book Description
The Geographical Distribution of Animal Viral Diseases attempts to shed some light on the global distribution of 110 different viral diseases, mainly of livestock and companion animals. The world literature was screened for 110 different viruses, and maps were prepared. These maps delineate the global distribution of pathogenic viruses based on authenticated reports from a variety of reliable sources. Four viruses were categorized as affecting more than one species to a significant degree (astrovirus, rabies, rotaviruses, and Rift Valley fever). The largest number of maps involved viruses that affect humans. Of the 28 viruses a large number were from the California encephalitis group. Ten of the 28 viruses were reported only in the Eastern Hemisphere, 14 only in the Western Hemisphere, and four were worldwide. Birds were the next most frequently affected group with the 15 viruses, followed by pigs with 14 viruses. Overall the vector-borne viruses appear to have much sharper and clear-cut geographical boundaries than the others.
Author: S.R. Palmer
Publisher: OUP Oxford
ISBN: 9780198570028
Category : Medical
Languages : en
Pages : 0
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Divided into three sections along the lines of bacteriology, parasitology and virology, this book comprehensively provides a systematic, cross disciplinary approach to the science and control of all zoonoses, written by international specialists in human and veterinary medicine.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309259363
Category : Medical
Languages : en
Pages : 418
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Book Description
Globalization of the food supply has created conditions favorable for the emergence, reemergence, and spread of food-borne pathogens-compounding the challenge of anticipating, detecting, and effectively responding to food-borne threats to health. In the United States, food-borne agents affect 1 out of 6 individuals and cause approximately 48 million illnesses, 128,000 hospitalizations, and 3,000 deaths each year. This figure likely represents just the tip of the iceberg, because it fails to account for the broad array of food-borne illnesses or for their wide-ranging repercussions for consumers, government, and the food industry-both domestically and internationally. A One Health approach to food safety may hold the promise of harnessing and integrating the expertise and resources from across the spectrum of multiple health domains including the human and veterinary medical and plant pathology communities with those of the wildlife and aquatic health and ecology communities. The IOM's Forum on Microbial Threats hosted a public workshop on December 13 and 14, 2011 that examined issues critical to the protection of the nation's food supply. The workshop explored existing knowledge and unanswered questions on the nature and extent of food-borne threats to health. Participants discussed the globalization of the U.S. food supply and the burden of illness associated with foodborne threats to health; considered the spectrum of food-borne threats as well as illustrative case studies; reviewed existing research, policies, and practices to prevent and mitigate foodborne threats; and, identified opportunities to reduce future threats to the nation's food supply through the use of a "One Health" approach to food safety. Improving Food Safety Through a One Health Approach: Workshop Summary covers the events of the workshop and explains the recommendations for future related workshops.
Author: Shamim I. Ahmad
Publisher: Springer Nature
ISBN: 303071165X
Category : Medical
Languages : en
Pages : 745
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Book Description
This book discusses current evidence on human viruses and provides an extensive coverage of newly emerged viruses and current strategies for treatment. Offering a new perspective in view of the re-emergence of Ebola in African countries and Dengue in India and Pakistan, the contents include chapters on emergence, pathogenicity, epidemiology and vaccine uptake. Human Viruses: Diseases, Treatments and Vaccines: The New Insights discusses a range of viruses from the most common such as Influenza and Hepatitis to Zika, Poliomyelitis and Chikungunya among many others. It is authored by a team of experts on viral disease and will be of immense use to virologists, public health experts and clinicians.
Author: Romain Paillot
Publisher: MDPI
ISBN: 3039283200
Category : Science
Languages : en
Pages : 230
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Book Description
The Food and Agriculture Organization of the United Nations has recently estimated that the world equid population exceeds 110 million. Working equids (horses, ponies, donkeys, and mules) remain essential to ensure the livelihood of poor communities around the world. In many developed countries, the equine industry has significant economical weight, with around 7 million horses in Europe alone. The close relationship between humans and equids and the fact that the athlete horse is the terrestrial mammal that travels the most worldwide after humans are important elements to consider in the transmission of pathogens and diseases, amongst equids and to other species. The potential effect of climate change on vector ecology and vector-borne diseases is also of concern for both human and animal health. In this Special Issue, we intend to explore our understanding of a panel of equine viruses, looking at their pathogenicity, their importance in terms of welfare and potential association with diseases, their economic importance and impact on performance, and how their identification can be helped by new technologies and methods.
