Molecular Analysis of the Dimerization Properties of Thyroid Hormone Recetor [i.e. Receptor] and Its Oncogenic Receptor, V-Erb A PDF Download
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Author: Sang-Ho Lee
Publisher:
ISBN:
Category :
Languages : en
Pages : 394
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Book Description
![Molecular Analysis of the Dimerization Properties of Thyroid Hormone Recetor [i.e. Receptor] and Its Oncogenic Receptor, V-Erb A PDF](https://books.google.com/books/content/images/frontcover/e1dFzvyLVS8C?fife=w80-h100)
Author: Sang-Ho Lee
Publisher:
ISBN:
Category :
Languages : en
Pages : 394
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Book Description
Author: Aria Baniahmad
Publisher: Springer Science & Business Media
ISBN: 1592591744
Category : Medical
Languages : en
Pages : 232
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Book Description
A panel of outstanding investigators surveys and explains the major cutting-edge methods used in thryroid receptor (TR) research and explains their practical experimental details. Described in step-by-step detail to ensure robust experimental results, the techniques presented cover a wide variety of key areas, including TR in development and knockout (mouse and Xenopus), transcriptional regulation by TRs in both cell-free systems and in living cells, and TR mutant analysis of patients. Additional methods provide powerful tools for the isolation of TR-regulated protein complexes, for studying the oncogene v-Erba in blood cell differentiation, and for target gene analysis in the brain. Microarray chip methods are also presented for analyzing the organs of transgenic mice to identify target genes in the liver.
Author: Tammy L. Bone
Publisher:
ISBN:
Category : Thyroid gland
Languages : en
Pages : 108
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Book Description
Author: G.R. Williams
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 160
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Book Description
This book covers the historical perspective and physiological background of the role of thyroid hormones. In both specific target tissues and during development, it provides clinical perspectives and physiological and developmental implications of the interactions between retinoid and vitamin D3 signalling pathways.
Author: Theresa Qui Phan
Publisher:
ISBN: 9781109662948
Category :
Languages : en
Pages :
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Book Description
Thyroid hormone receptors (TRs) and retinoic acid receptors (RARs) are members of the nuclear hormone receptor family. These ligand-regulated transcription factors bind to specific DNA sequences, called response elements, as homodimers or heterodimers with retinoid-X receptor (RXR) and regulate specific target genes. In the absence of hormone, TR and RAR repress transcription by recruiting corepressor complexes. In the presence of hormone, a coactivator complex is recruited and results in transcriptional activation. TRs and RARs are highly structurally conserved and possess very similar DNA binding domains. Despite these similarities, these receptors bind to different response elements in the genome, regulate different target genes, and control distinct physiological processes. The work presented in this dissertation identifies the DNA recognition properties of TR and RAR that account for these receptors' response element binding specificity and, subsequently, their distinct physiological responses. While response elements based on the consensus half-site are high affinity binding sites for TR and RAR, they show poor specificity. In contrast, the variations in half-site sequence, flanking sequences, and spacing found in natural TR and RAR target genes generate response elements that are bound in vitro and transcriptionally activated in vivo in a receptor-specific manner. Not all DNA sequences that bind TR or RAR efficiently in vitro are able to confer transcriptional regulation in vivo; we provide evidence that auxiliary proteins in cells may destabilize the binding of nuclear receptors to improperly spaced response elements to generate an additional layer of receptor-specific target gene recognition.
Author:
Publisher: Academic Press
ISBN: 0121432602
Category :
Languages : en
Pages : 437
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Book Description
Author:
Publisher: Elsevier
ISBN: 0443134561
Category : Science
Languages : en
Pages : 688
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Book Description
Hormone Receptors: Structures and Functions, Volume 123 in the Vitamins and Hormones series, highlights new advances in the field with this new volume presenting interesting chapters written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Vitamins and Hormones series - Updated release includes the latest information on Hormone Receptors
Author: Iain J. McEwan
Publisher: Springer
ISBN: 3319187295
Category : Medical
Languages : en
Pages : 236
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Book Description
Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.
Author: Chi-Wai Wong
Publisher:
ISBN:
Category :
Languages : en
Pages : 496
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Book Description
Author:
Publisher: Academic Press
ISBN: 0128141174
Category : Science
Languages : en
Pages : 566
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Book Description
Thyroid hormone, Volume 106, the latest release in the Vitamins and Hormones series first published in 1943 provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions and the biological actions of neurotrophins related to clinical conditions and disease. This new release focuses on timely topics, including the Nuclear Import and Export of the Thyroid Hormone Receptor, the Thyroid hormone and the white matter of the central nervous system: from development to repair, Thyroid hormone and astrocyte differentiation, and the Molecular Basis of Nongenomic Actions of Thyroid Hormone, amongst other topics. - Presents the latest information on thyroid hormone - Provides a long-running series that focuses on updates and advances in vitamins and hormones - Covers single molecules or diseases that are related to vitamins or hormones, with the topic broadly interpreted to include related substances
