Modulating Protein Aggregation with Targeted, Surface Tension-modifying Compounds PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Modulating Protein Aggregation with Targeted, Surface Tension-modifying Compounds PDF full book. Access full book title Modulating Protein Aggregation with Targeted, Surface Tension-modifying Compounds by Todd Jonathan Gibson. Download full books in PDF and EPUB format.
Author: Todd Jonathan Gibson
Publisher:
ISBN:
Category :
Languages : en
Pages : 194
Get Book Here
Book Description
Author: Todd Jonathan Gibson
Publisher:
ISBN:
Category :
Languages : en
Pages : 194
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 780
Get Book Here
Book Description
Author: Mariano Bizzarri
Publisher: Springer Nature
ISBN: 3030328570
Category : Medical
Languages : en
Pages : 493
Get Book Here
Book Description
This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
Author: Jin Ryoun Kim
Publisher:
ISBN:
Category :
Languages : en
Pages : 216
Get Book Here
Book Description
![Role of Transformation in Modulating [beta]-amyloid Aggregation and Toxicity PDF](https://books.google.com/books/content/images/frontcover/XYysAAAAMAAJ?fife=w80-h100)
Author: Lin Liu
Publisher:
ISBN:
Category :
Languages : en
Pages : 178
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1940
Get Book Here
Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author: Jennifer J. McManus
Publisher: Humana
ISBN: 9781493996803
Category : Science
Languages : en
Pages : 266
Get Book Here
Book Description
This volume explores experimental and computational approaches to measuring the most widely studied protein assemblies, including condensed liquid phases, aggregates, and crystals. The chapters in this book are organized into three parts: Part One looks at the techniques used to measure protein-protein interactions and equilibrium protein phases in dilute and concentrated protein solutions; Part Two describes methods to measure kinetics of aggregation and to characterize the assembled state; and Part Three details several different computational approaches that are currently used to help researchers understand protein self-assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Protein Self-Assembly: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field.
Author: Pierre Lambert
Publisher: MDPI
ISBN: 3039215647
Category : Technology & Engineering
Languages : en
Pages : 240
Get Book Here
Book Description
Building on advances in miniaturization and soft matter, surface tension effects are a major key to the development of soft/fluidic microrobotics. Benefiting from scaling laws, surface tension and capillary effects can enable sensing, actuation, adhesion, confinement, compliance, and other structural and functional properties necessary in micro- and nanosystems. Various applications are under development: microfluidic and lab-on-chip devices, soft gripping and manipulation of particles, colloidal and interfacial assemblies, fluidic/droplet mechatronics. The capillary action is ubiquitous in drops, bubbles and menisci, opening a broad spectrum of technological solutions and scientific investigations. Identified grand challenges to the establishment of fluidic microrobotics include mastering the dynamics of capillary effects, controlling the hysteresis arising from wetting and evaporation, improving the dispensing and handling of tiny droplets, and developing a mechatronic approach for the control and programming of surface tension effects. In this Special Issue of Micromachines, we invite contributions covering all aspects of microscale engineering relying on surface tension. Particularly, we welcome contributions on fundamentals or applications related to: Drop-botics: fluidic or surface tension-based micro/nanorobotics: capillary manipulation, gripping, and actuation, sensing, folding, propulsion and bio-inspired solutions; Control of surface tension effects: surface tension gradients, active surfactants, thermocapillarity, electrowetting, elastocapillarity; Handling of droplets, bubbles and liquid bridges: dispensing, confinement, displacement, stretching, rupture, evaporation; Capillary forces: modelling, measurement, simulation; Interfacial engineering: smart liquids, surface treatments; Interfacial fluidic and capillary assembly of colloids and devices; Biological applications of surface tension, including lab-on-chip and organ-on-chip systems.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9789241208901
Category : Cooking
Languages : en
Pages : 212
Get Book Here
Book Description
Joint FAO/IAEA/WHO Study Group on High-Dose Irradiation (Wholesomeness of Food Irradiated with Doses Above 10 kGy), Geneva, 15-20 September 1997
Author: Cláudio M. Gomes
Publisher: Frontiers Media SA
ISBN: 2889742512
Category : Science
Languages : en
Pages : 153
Get Book Here
Book Description
