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Author: Sabine Stübler
Publisher: Springer
ISBN: 3658201673
Category : Medical
Languages : en
Pages : 108
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Book Description
Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.
Author: Sabine Stübler
Publisher: Springer
ISBN: 3658201673
Category : Medical
Languages : en
Pages : 108
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Book Description
Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.
Author: José M. Bernardo
Publisher: Oxford University Press
ISBN: 0191627852
Category : Mathematics
Languages : en
Pages :
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Book Description
The Valencia International Meetings on Bayesian Statistics - established in 1979 and held every four years - have been the forum for a definitive overview of current concerns and activities in Bayesian statistics. These are the edited Proceedings of the Ninth meeting, and contain the invited papers each followed by their discussion and a rejoinder by the authors(s). In the tradition of the earlier editions, this encompasses an enormous range of theoretical and applied research, high lighting the breadth, vitality and impact of Bayesian thinking in interdisciplinary research across many fields as well as the corresponding growth and vitality of core theory and methodology. The Valencia 9 invited papers cover a broad range of topics, including foundational and core theoretical issues in statistics, the continued development of new and refined computational methods for complex Bayesian modelling, substantive applications of flexible Bayesian modelling, and new developments in the theory and methodology of graphical modelling. They also describe advances in methodology for specific applied fields, including financial econometrics and portfolio decision making, public policy applications for drug surveillance, studies in the physical and environmental sciences, astronomy and astrophysics, climate change studies, molecular biosciences, statistical genetics or stochastic dynamic networks in systems biology.
Author:
Publisher: Academic Press
ISBN: 0123849926
Category : Science
Languages : en
Pages : 472
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Book Description
This volume is dedicated to a description of the instruments, samples, protocols, and analyses that belong to cryo-EM. It emphasizes the relatedness of the ideas, instrumentation, and methods underlying all cryo-EM approaches, which allow practitioners to easily move between them. Within each section, the articles are ordered according to the most common symmetry of the sample to which their methods are applied. - Includes time-tested core methods and new innovations applicable to any researcher - Methods included are useful to both established researchers and newcomers to the field - Relevant background and reference information given for procedures can be used as a guide
Author: Eberhard O. Voit
Publisher: Garland Science
ISBN: 1136215107
Category : Computers
Languages : en
Pages : 465
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Book Description
A First Course in Systems Biology is a textbook designed for advanced undergraduate and graduate students. Its main focus is the development of computational models and their applications to diverse biological systems. Because the biological sciences have become so complex that no individual can acquire complete knowledge in any given area of specialization, the education of future systems biologists must instead develop a student's ability to retrieve, reformat, merge, and interpret complex biological information. This book provides the reader with the background and mastery of methods to execute standard systems biology tasks, understand the modern literature, and launch into specialized courses or projects that address biological questions using theoretical and computational means. The format is a combination of instructional text and references to primary literature, complemented by sets of small-scale exercises that enable hands-on experience, and larger-scale, often open-ended questions for further reflection.
Author: Edwin Wang
Publisher: CRC Press
ISBN: 1439811865
Category : Computers
Languages : en
Pages : 458
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Book Description
The unprecedented amount of data produced with high-throughput experimentation forces biologists to employ mathematical representation and computation to glean meaningful information in systems-level biology. Applying this approach to the underlying molecular mechanisms of tumorgenesis, cancer research is enjoying a series of new discoveries and biological insights. Unique in its dualistic approach, this book introduces the concepts and theories of systems biology and their applications in cancer research. It presents basic cancer biology and cutting-edge topics of cancer research for computational biologists alongside systems biology analysis tools for experimental biologists.
Author: Fabio Trovato
Publisher: Frontiers Media SA
ISBN: 2889740250
Category : Science
Languages : en
Pages : 322
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Book Description
Author: Stefan Jentsch
Publisher: Springer
ISBN: 9783540873259
Category : Medical
Languages : en
Pages : 191
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Book Description
Author: Kim-Anh Do
Publisher: Cambridge University Press
ISBN: 052186092X
Category : Mathematics
Languages : en
Pages : 437
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Book Description
Expert overviews of Bayesian methodology, tools and software for multi-platform high-throughput experimentation.
Author: Konrad Beyreuther
Publisher: Springer Science & Business Media
ISBN: 3642842240
Category : Medical
Languages : en
Pages : 327
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Book Description
Author: SUSAN. HUBER HOLMES (WOLFGANG.)
Publisher: Cambridge University Press
ISBN: 1108427022
Category : Biometry
Languages : en
Pages : 407
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Book Description
