Model Organisms in Spinal Cord Regeneration PDF Download
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Author: Catherina G. Becker
Publisher: John Wiley & Sons
ISBN: 3527610359
Category : Medical
Languages : en
Pages : 423
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Book Description
This handbook provides a comprehensive overview for students, clinicians and researchers planning to enter the field of neural regeneration, combining the latest knowledge with an understanding of all important model organisms in one handy volume. By covering the strengths and weaknesses as well as possible applications of different models it saves researchers both time and resources in their choice of the appropriate model organism. An equally valuable introduction for the novice planning to enter the field.
Author: Catherina G. Becker
Publisher: John Wiley & Sons
ISBN: 3527610359
Category : Medical
Languages : en
Pages : 423
Get Book Here
Book Description
This handbook provides a comprehensive overview for students, clinicians and researchers planning to enter the field of neural regeneration, combining the latest knowledge with an understanding of all important model organisms in one handy volume. By covering the strengths and weaknesses as well as possible applications of different models it saves researchers both time and resources in their choice of the appropriate model organism. An equally valuable introduction for the novice planning to enter the field.
Author: Catherina G. Becker
Publisher: John Wiley & Sons
ISBN: 9783527315048
Category : Medical
Languages : en
Pages : 430
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Book Description
This handbook provides a comprehensive overview for students, clinicians and researchers planning to enter the field of neural regeneration, combining the latest knowledge with an understanding of all important model organisms in one handy volume. By covering the strengths and weaknesses as well as possible applications of different models it saves researchers both time and resources in their choice of the appropriate model organism. An equally valuable introduction for the novice planning to enter the field.
Author: Wei Wang
Publisher: Springer Nature
ISBN: 1071628755
Category : Medical
Languages : en
Pages : 361
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Book Description
This volume discusses different approaches towards understanding the brain plasticity, aging, and regeneration of the nervous system in model organisms. Chapters guide the reader through an overview of model organisms, setup of an aquatic system, Tol2-mediated transgenesis, CRISPR/Cas9-mediated gene knock-out and knock-in, Cas13d-mediated gene knockdown, tissue clearing and expansion methods for brain and spinal cord imaging, Histological techniques, chromatin Immunoprecipitation Sequencing (ChIP-Seq) analysis, single-cell RNA sequencing analysis, BrdU/EdU incorporation assays, brain and spinal cord injury in African killifish, and emerging technologies and future perspectives in African killifish research. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Authoritative and cutting-edge, Emerging Model Organisms aims to be a useful practical guide to researches to help further their study in this field.
Author: Aldskogius H Kan
Publisher: Humana Press
ISBN: 9781493961801
Category : Medical
Languages : en
Pages : 350
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Book Description
This book in the Neuromethods series examines a range of experimental models for research on spinal cord injury, shows how they have contributed to our current state of knowledge, and describes their advantages in the further advancement of spinal cord repair.
Author: Patrick D. Skelton
Publisher:
ISBN:
Category :
Languages : en
Pages : 34
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Book Description
Author: Heidi Fuller
Publisher: BoD – Books on Demand
ISBN: 9535124978
Category : Medical
Languages : en
Pages : 332
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Book Description
Restoration of motor function following spinal cord injury is a complex and challenging task. By reviewing emerging cellular, pharmacological, rehabilitative, as well as surgical approaches, this book seeks to highlight promising therapeutic strategies for the repair and regeneration of motor circuitry. The multidisciplinary nature of these approaches illustrates various routes to bridging the gap between the bench and the bedside and to identify the challenges that must be overcome in order to bring about a viable therapeutic strategy for spinal cord injury patients.
Author: Michelle Tu
Publisher:
ISBN: 9781303792724
Category :
Languages : en
Pages :
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Book Description
Tissue regeneration entails replenishing of damaged cells, appropriate cell differentiation and inclusion of regenerated cells into functioning tissues. In adult humans, the capacity of the injured spinal cord and muscle to self-repair is limited. In contrast, the amphibian larva can regenerate its tail after amputation with complete recovery of muscle, notochord and spinal cord. However, the cellular and molecular mechanisms underlying this phenomenon are still unclear. Determining these mechanisms in a model organism that exhibits this exceptional capacity to self-repair may provide the knowledge for novel therapeutic approaches to promote human tissue regeneration. One factor that has been identified as relevant for tail regeneration is electrical activity, which also plays an important role in early development of muscle and spinal cord. We hypothesize that calcium-mediated electrical activity manifests in regenerating tissues and that this activity is necessary for proper muscle and spinal cord regeneration. Calcium (Ca2+) imaging experiments show that regenerating tissues exhibit Ca2+-mediated electrical activity during the first day post-amputation. More specifically, muscle cells exhibit Ca2+ transients that depend on Ca2+ release from stores. We also find that blockade of Ca2+-mediated electrical activity impairs muscle and spinal cord regeneration. Furthermore, inhibiting Ca2+ transients in the regenerating muscle prevents the activation and proliferation of muscle satellite cells, which results in poor muscle regeneration.Our findings suggest that Ca2+-mediated electrical activity is critical for the early stages of regeneration and required for proper muscle and spinal cord regeneration. Our work contributes to understanding how Ca2+-mediated electrical activity promotes repair of injured tissues and may lead to improved therapies for tissue regeneration.
Author: Jun Chen
Publisher: Springer Science & Business Media
ISBN: 1603271856
Category : Medical
Languages : en
Pages : 490
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Book Description
Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation. Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.
Author: Jeffrey Kordower
Publisher: Elsevier
ISBN: 0080556981
Category : Medical
Languages : en
Pages : 523
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Book Description
This second edition of CNS Regeneration updates the burgeoning field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. While the book covers numerous areas in detail, special emphasis is given to discussions of movement disorders such as Parkinson’s disease, Alzheimer’s disease, and spinal cord injury. Incorporates information gained from cutting-edge photomicroscopy techniques Includes current information on clinical trials Presents chapters on stem cells and other novel treatments for diseases of the CNS
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309252113
Category : Science
Languages : en
Pages : 102
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Book Description
Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. To consider animal research regulations from a global perspective, the IOM Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council and the Institute for Laboratory Animal Research, held a workshop in Buckinghamshire, UK, July 26-27, 2011. The workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences. This document summarizes the workshop.
