Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery PDF full book. Access full book title Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery by Busi Siddhardha. Download full books in PDF and EPUB format.
Author: Busi Siddhardha
Publisher: Springer Nature
ISBN: 9811516952
Category : Science
Languages : en
Pages : 685
Get Book Here
Book Description
This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.
Author: Busi Siddhardha
Publisher: Springer Nature
ISBN: 9811516952
Category : Science
Languages : en
Pages : 685
Get Book Here
Book Description
This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.
Author: Tony Romeo
Publisher: Springer Science & Business Media
ISBN: 3540754180
Category : Medical
Languages : en
Pages : 302
Get Book Here
Book Description
Throughout the biological world, bacteria thrive predominantly in surface-attached, matrix-enclosed, multicellular communities or biofilms, as opposed to isolated planktonic cells. This choice of lifestyle is not trivial, as it involves major shifts in the use of genetic information and cellular energy, and has profound consequences for bacterial physiology and survival. Growth within a biofilm can thwart immune function and antibiotic therapy and thereby complicate the treatment of infectious diseases, especially chronic and foreign device-associated infections. Modern studies of many important biofilms have advanced well beyond the descriptive stage, and have begun to provide molecular details of the structural, biochemical, and genetic processes that drive biofilm formation and its dispersion. There is much diversity in the details of biofilm development among various species, but there are also commonalities. In most species, environmental and nutritional conditions greatly influence biofilm development. Similar kinds of adhesive molecules often promote biofilm formation in diverse species. Signaling and regulatory processes that drive biofilm development are often conserved, especially among related bacteria. Knowledge of such processes holds great promise for efforts to control biofilm growth and combat biofilm-associated infections. This volume focuses on the biology of biofilms that affect human disease, although it is by no means comprehensive. It opens with chapters that provide the reader with current perspectives on biofilm development, physiology, environmental, and regulatory effects, the role of quorum sensing, and resistance/phenotypic persistence to antimicrobial agents during biofilm growth.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309219396
Category : Science
Languages : en
Pages : 570
Get Book Here
Book Description
Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Author: Jun Lin
Publisher: Frontiers Media SA
ISBN: 2889195260
Category : Antibiotics
Languages : en
Pages : 226
Get Book Here
Book Description
Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.
Author: Thomas Bjarnsholt
Publisher: Springer
ISBN: 9781489982285
Category : Science
Languages : en
Pages : 0
Get Book Here
Book Description
This book will cover both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections such as diagnostics and treatment regimes. A still increasing interest and emphasis on the sessile bacterial lifestyle biofilms has been seen since it was realized that that less than 0.1% of the total microbial biomass lives in the planktonic mode of growth. The term was coined in 1978 by Costerton et al. who defined the term biofilm for the first time.In 1993 the American Society for Microbiology (ASM) recognised that the biofilmmode of growth was relevant to microbiology. Lately many articles have been published on the clinical implications of bacterial biofilms. Both original articles and reviews concerning the biofilm problem are available.
Author: Ajar Nath Yadav
Publisher: Springer Nature
ISBN: 9811569495
Category : Technology & Engineering
Languages : en
Pages : 578
Get Book Here
Book Description
Microbial biotechnology is an emerging field with applications in a broad range of sectors involving food security, human nutrition, plant protection and overall basic research in the agricultural sciences. The environment has been sustaining the burden of mankind from time immemorial, and our indiscriminate use of its resources has led to the degradation of the climate, loss of soil fertility, and the need for sustainable strategies. The major focus in the coming decades will be on achieving a green and clean environment by utilizing soil and plant-associated beneficial microbial communities. Plant-microbe interactions include the association of microbes with plant systems: epiphytic, endophytic and rhizospheric. The microbes associated with plant ecosystems play an important role in plant growth, development, and soil health. Moreover, soil and plant microbiomes help to promote plant growth, either directly or indirectly by means of plant growth-promoting mechanisms, e.g. the release of plant growth regulators; solubilization of phosphorus, potassium and zinc; biological nitrogen fixation; or by producing siderophores, ammonia, HCN and other secondary metabolites. These beneficial microbial communities represent a novel and promising solution for agro-environmental sustainability by providing biofertilizers, bioprotectants, and biostimulants, in addition to mitigating various types of abiotic stress in plants. This book focuses on plant-microbe interactions; the biodiversity of soil and plant microbiomes; and their role in plant growth and soil health. Accordingly, it will be immensely useful to readers working in the biological sciences, especially microbiologists, biochemists and microbial biotechnologists.
Author: Mahmoud Ghannoum
Publisher: John Wiley & Sons
ISBN: 1683673336
Category : Science
Languages : en
Pages : 636
Get Book Here
Book Description
An examination of the research and translational application to prevent and treat biofilm-associated diseases In the decade since the first edition of Microbial Biofilms was published, the interest in this field has expanded, spurring breakthrough research that has advanced the treatment of biofilm-associated diseases. This second edition takes the reader on an exciting, extensive review of bacterial and fungal biofilms, ranging from basic molecular interactions to innovative therapies, with particular emphasis on the division of labor in biofilms, new approaches to combat the threat of microbial biofilms, and how biofilms evade the host defense. Chapters written by established investigators cover recent findings, and contributions from investigators new to the field provide unique and fresh insights. Specifically, Microbial Biofilms provides state-of-the-art research in the field of bacterial and fungal biofilms detailed descriptions of the in vitro and in vivo models available to evaluate microbial biofilms future areas of research and their translational and clinical applications Microbial Biofilms is a useful reference for researchers and clinicians. It will also provide insight in the dynamic field of microbial biofilms for graduate and postgraduate students.
Author: Siddhardha Busi
Publisher: Springer Nature
ISBN: 9819987997
Category :
Languages : en
Pages : 546
Get Book Here
Book Description
Author: Raghvendra Pratap Singh
Publisher: Springer Nature
ISBN: 9811656177
Category : Science
Languages : en
Pages : 375
Get Book Here
Book Description
The book overviews the complex interactions amongst the microbes and their possible applications. Emphasis has been made to include a wide spectrum of experimental and theoretical contributions from eminent researchers in the field. Microbial communities are the assemblages of microorganisms of various species which live together in the same environment and continuously interact with each other. The microbial cells in communities display unique phenotypes that affect the survival and reproduction of other cells present around them. These phenotypes constitute the social adaptations that drive the interactions between microbial cells. The interactions, further determine the productivity, stability and the ability of community to resist the environmental perturbations. These microbial communities live with extremely competitive niche and fight for their survival and genetic persistence. But they frequently appear in niche with multifaceted and interactive webs rather than the planktonic nature. This can be within the same species or with different species, or even with diverse genera and families. It either a competitive winner community whereas the “weaker” strain goes extinct or a competitor that coexist with their metabolic secretory potentials or a separator that assigned their own community territorial niches. Sometimes, it can be neutral or tritagonist. These microbial associations within the microbiome provides the foundation for diverse forms of microbial ecology and determined the applied perspectives for agriculture, clinical and industrial sectors. This book will be useful to postgraduate students, researchers from academic as well as industry working in the field of microbial exploration with keen interest in survival factors and mechanism of their survival by various ecological and functional strategies.
Author: Prasann Kumar
Publisher: Elsevier
ISBN: 0443139946
Category : Science
Languages : en
Pages : 725
Get Book Here
Book Description
Bioremediation of Emerging Contaminants from Soils: Soil Health Conservation Along with Food Security deals with current challenges of sustainable soil health using eco-friendly approaches. This book provides ways of reducing the chemicals burden on the soil by maintaining balance in terms of society, environment and economy, which are considered basic pillars of sustainability. Designed to highlight soil health best practices for both environmental and agricultural sustainability, these approaches are also considered important for improving global food security by ensuring safe growing conditions for crops for food and feed. Presented in two parts, the book first highlights emerging contaminants and their sources. The second part explores a variety of steps and tools for addressing contaminated soils including bio- and phytoremediation options. Case studies in each part provide real-world insights for practical application. This book will be unique in the specified area of sustainability using the principles of bioremediation. Moreover, scientists, researchers, and policymakers will receive insights to develop and explore innovate approaches to achieve sustainable development goals. - Contains the latest practical and theoretical aspects of the soil health crisis and its management - Presents collective information to ensure the remediation of soil from emerging contaminants - Serves as baseline information for environmental issues in agriculture along with their alternative eco-friendly solutions
