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Author: Minor Coon
Publisher: Elsevier
ISBN: 0323143873
Category : Medical
Languages : en
Pages : 655
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Book Description
Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume II, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. Volume I contained 117 contributions made by researchers at the symposium, which were organized into three sections (Sections I-III). This second volume contains 122 contributions, divided into four sections (Sections IV-VII). The papers on Section IV examine the metabolic fate of oxygenated compounds. Section V provides studies on microsomal enzymes and lipid metabolism. Section VI includes papers on microsomal enzymes and toxicity of foreign compounds. Section VII covers microsomal enzymes and chemical mutagenesis and carcinogenesis. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.
Author: Minor Coon
Publisher: Elsevier
ISBN: 0323143873
Category : Medical
Languages : en
Pages : 655
Get Book Here
Book Description
Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume II, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. Volume I contained 117 contributions made by researchers at the symposium, which were organized into three sections (Sections I-III). This second volume contains 122 contributions, divided into four sections (Sections IV-VII). The papers on Section IV examine the metabolic fate of oxygenated compounds. Section V provides studies on microsomal enzymes and lipid metabolism. Section VI includes papers on microsomal enzymes and toxicity of foreign compounds. Section VII covers microsomal enzymes and chemical mutagenesis and carcinogenesis. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.
Author: Minor Coon
Publisher: Elsevier
ISBN: 0323144098
Category : Medical
Languages : en
Pages : 645
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Book Description
Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume I, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. The book contains 117 contributions made by researchers at the symposium, which are organized into three sections. The papers in Section I focus on the chemical and physical characteristics of cytochrome P-450. Section II examines the mechanisms of action of cytochrome P-450 and related enzymes. The studies in Section III deal with the influence of membrane structure and protein synthesis on electron transfer components. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.
Author: Robert Snyder
Publisher: Springer
ISBN: 147570674X
Category : Science
Languages : en
Pages : 832
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Book Description
Author: B.H. Dunford
Publisher: Springer Science & Business Media
ISBN: 9789027714442
Category : Science
Languages : en
Pages : 542
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Book Description
Proceedings of the NATO Advanced Study Institute, Edmonton, Alberta, Canada, August 23-September 4, 1981
Author: Robert Langenbach
Publisher: Springer Science & Business Media
ISBN: 146844400X
Category : Medical
Languages : en
Pages : 680
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Book Description
The Symposium on Organ and Species Specificity in Chemical Carcinogenesis was held March 1981 in Raleigh, North Carolina. Dr. James Miller concluded this Symposium with these remarks: "Without a doubt all of us would agree this has been a very successful symposium in illustrating a very wide range of chemical, stereochemical, biochemical, metabolic, molecular, and biological factors in chemical carcinogenesis. I think it is noteworthy that many of the discussions have dealt with pharmacodynamic, or toxicodynamic, factors that can influence the biological activities of the extremely wide range of structures that we choose to call chemical carcinogens. I sincerely hope that after this symposium everyone here will realize the very great need we have for further information on these agents in the species we profess to be working for, the human species. We badly need an adequate data base on human organs, human tissues, human cells, human subcellular preparations, and human body fluids. I don't think we can rely on extrapolations of data on chemical carcinogenesis from experimental animals to humans, no matter how sophisticated or plausible these extrapolations may seem, until we know far more about chemical carcinogenesis in humans. Now, I'd like to add a somewhat personal note. As many of you know, my wife and I have shared a joint career of some 40 years in this field, and I'd like to emphasize in these closing remarks the factor of youth.
Author: National Institutes of Health (U.S.)
Publisher:
ISBN:
Category : Medical research personnel
Languages : en
Pages : 504
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Book Description
Author: National Institutes of Health (U.S.)
Publisher:
ISBN:
Category : Biochemistry
Languages : en
Pages : 496
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Book Description
Each issue lists papers published during the preceding year.
Author: John N. Hathcock
Publisher: Elsevier
ISBN: 0323138306
Category : Medical
Languages : en
Pages : 317
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Book Description
Nutritional Toxicology, Volume II, discusses the various interactions between nutritional phenomena and toxicologic processes. It addresses particular subjects that have become substantially more important through the development of new knowledge, significant increases in knowledge, or increased awareness of potential effects on human health and well-being. The implications of such knowledge have impact on basic research, toxicity testing, public health, food, and agriculture programs, and food safety regulation. The book begins with a review of the role and importance of macro- and micronutrients on detoxification processes of foreign compounds after absorption. This is followed by separate chapters on mixed-function oxidation in the liver; the metabolic and nutritional effects of ethanol; the effects of malnutrition on drug metabolism; interaction of nutrient intake with DNA and chromatin; and how such interactions may affect the process of toxicogenesis in the nucleus. Subsequent chapters cover mutagens in cooked foods; food sensitivities; anatomical, cardiovascular, and behavioral effects of dietary caffeine; the toxicology of dietary tin, aluminum, and selenium; and the toxicology of pesticides in foods.
Author: Francisco Feo
Publisher: Springer Science & Business Media
ISBN: 1475796404
Category : Science
Languages : en
Pages : 646
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Book Description
About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.
Author: John Caldwell
Publisher: Elsevier
ISBN: 0323150101
Category : Nature
Languages : en
Pages : 444
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Book Description
Biological Basis of Detoxication focuses on the biological processes involved in detoxication, with emphasis on the biochemistry of the removal of xenobiotics from an organism. Topics range from the formation of toxic metabolites and compounds that are not metabolized at all to the tissue distribution and nutritional considerations, the kinetics and mechanisms of the metabolic and excretory processes, and the integration of xenobiotic metabolism in the activation and detoxication of carcinogens. Organized into 14 chapters, this book begins with an overview of the enzymatic basis for the metabolic activation of foreign compounds in forming reactive chemical intermediates. The first few chapters discuss the identification of reactive electrophiles derived from xenobiotics, intratissue distribution of activating and detoxicating enzymes, enzymatic and non-enzymatic modes of xenobiotic metabolism, and unmetabolized compounds. The middle chapters explore the biological basis of detoxication of oxygen free radicals, physiologic and kinetic aspects of the fate of xenobiotics, excretion of xenobiotics, and effects of nutrition on detoxication. The remaining chapters look at the relationships between the enzymes of detoxication and host defense mechanisms, metabolic basis of target organ toxicity, the enzymatic factor in selective toxicity, and intraindividual and interindividual variations in rates of hepatic metabolism of exogenous chemicals. Pharmacologists, toxicologists, and biochemists will find this book highly informative.
