Author: Alexander V. Oleskin
Publisher:
ISBN: 9781536175066
Category : Cell interaction
Languages : en
Pages : 389
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Book Description
"In light of recent data, microorganisms are construed in the present monograph as living organisms that are capable of communication and advanced social organization, which conspicuously manifests itself in the formation of extracellular matrix-enclosed biofilms. Microbial communication signals, including quorum sensing pheromones, are of paramount importance both for interactions among microbial cells and the dialogue between them and the host organism. The monograph sums up the facts that demonstrate the complexity of the human organism-inhabiting microbial consortium comprising a wide variety of biofilm-forming eukaryotic, bacterial and archean cells. The microbiota is involved in maintaining microecological, metabolic, epigenetic, neuro-endocrine and immune homeostasis that normally stabilizes the brain-gut-microbiota axis. Microbially produced neuroactive chemicals include peptides, amino acids, amines, short-chain fatty acids, purines and gaseous substances that are used as nutrients, effectors, cofactors and signals by the host organism. In the present-day world, the human organism has to deal with a large number of environmental stress factors that overpower the organism's protective system and disrupt the functioning of symbiotic microbiota predominantly located in the gastro-intestinal (GI) tract. Homeostasis disruption may impede communication between microbial cells and the human organism and cause physical or mental health problems. The operation of the brain-gut-microbiota axis can be improved by useful microorganisms (probiotics) including psychobiotics that directly impact the human brain and behavior. In the authors' opinion, the lifelong epigenetic developmental program of the organism can be ameliorated and genetic and epigenetic disruptions in the human metagenome (comprising all nuclear, mitochondrial and microbial genes) can be prevented by supplementing the diet with traditional, organic and individualized functional food items that relieve the effects of various detrimental stress factors and agents. A reasonably designed lifestyle based on gut microbiota optimization will undoubtedly help human individuals live a decent healthy life and attain active longevity. Current research on the population organization, social behavior and intercellular communication of microorganisms is expected to promote the interdisciplinary dialogue between microbiology, cytology and ethology. In addition, the results of this research are of significant potential importance for medicine and biotechnology"--
Author: Alexander V. Oleskin
Publisher: Nova Science Publishers
ISBN: 9781536175073
Category : Science
Languages : en
Pages : 389
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Book Description
"In light of recent data, microorganisms are construed in the present monograph as living organisms that are capable of communication and advanced social organization, which conspicuously manifests itself in the formation of extracellular matrix-enclosed biofilms. Microbial communication signals, including quorum sensing pheromones, are of paramount importance both for interactions among microbial cells and the dialogue between them and the host organism. The monograph sums up the facts that demonstrate the complexity of the human organism-inhabiting microbial consortium comprising a wide variety of biofilm-forming eukaryotic, bacterial and archean cells. The microbiota is involved in maintaining microecological, metabolic, epigenetic, neuro-endocrine and immune homeostasis that normally stabilizes the brain-gut-microbiota axis. Microbially produced neuroactive chemicals include peptides, amino acids, amines, short-chain fatty acids, purines and gaseous substances that are used as nutrients, effectors, cofactors and signals by the host organism. In the present-day world, the human organism has to deal with a large number of environmental stress factors that overpower the organism's protective system and disrupt the functioning of symbiotic microbiota predominantly located in the gastro-intestinal (GI) tract. Homeostasis disruption may impede communication between microbial cells and the human organism and cause physical or mental health problems. The operation of the brain-gut-microbiota axis can be improved by useful microorganisms (probiotics) including psychobiotics that directly impact the human brain and behavior. In the authors' opinion, the lifelong epigenetic developmental program of the organism can be ameliorated and genetic and epigenetic disruptions in the human metagenome (comprising all nuclear, mitochondrial and microbial genes) can be prevented by supplementing the diet with traditional, organic and individualized functional food items that relieve the effects of various detrimental stress factors and agents. A reasonably designed lifestyle based on gut microbiota optimization will undoubtedly help human individuals live a decent healthy life and attain active longevity. Current research on the population organization, social behavior and intercellular communication of microorganisms is expected to promote the interdisciplinary dialogue between microbiology, cytology and ethology. In addition, the results of this research are of significant potential importance for medicine and biotechnology"--
Author: Mark Lyte
Publisher: Springer Science & Business Media
ISBN: 1441955763
Category : Medical
Languages : en
Pages : 325
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Book Description
Microbial endocrinology represents a newly emerging interdisciplinary field that is formed by the intersection of the fields of neurobiology and microbiology. This book will introduce a new perspective to the current understanding not only of the factors that mediate the ability of microbes to cause disease, but also to the mechanisms that maintain normal homeostasis. The discovery that microbes can directly respond to neuroendocrine hormones, as evidenced by increased growth and production of virulence-associated factors, provides for a new framework with which to investigate how microorganisms interface not only with vertebrates, but also with invertebrates and even plants. The reader will learn that the neuroendocrine hormones that one most commonly associates with mammals are actually found throughout the plant, insect and microbial communities to an extent that will undoubtedly surprise many, and most importantly, how interactions between microbes and neuroendocrine hormones can influence the pathophysiology of infectious disease.
Author: Mark Lyte
Publisher: Springer
ISBN: 1493908979
Category : Science
Languages : en
Pages : 440
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Book Description
The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host (“us”). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309264324
Category : Medical
Languages : en
Pages : 633
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Book Description
Beginning with the germ theory of disease in the 19th century and extending through most of the 20th century, microbes were believed to live their lives as solitary, unicellular, disease-causing organisms . This perception stemmed from the focus of most investigators on organisms that could be grown in the laboratory as cellular monocultures, often dispersed in liquid, and under ambient conditions of temperature, lighting, and humidity. Most such inquiries were designed to identify microbial pathogens by satisfying Koch's postulates.3 This pathogen-centric approach to the study of microorganisms produced a metaphorical "war" against these microbial invaders waged with antibiotic therapies, while simultaneously obscuring the dynamic relationships that exist among and between host organisms and their associated microorganisms-only a tiny fraction of which act as pathogens. Despite their obvious importance, very little is actually known about the processes and factors that influence the assembly, function, and stability of microbial communities. Gaining this knowledge will require a seismic shift away from the study of individual microbes in isolation to inquiries into the nature of diverse and often complex microbial communities, the forces that shape them, and their relationships with other communities and organisms, including their multicellular hosts. On March 6 and 7, 2012, the Institute of Medicine's (IOM's) Forum on Microbial Threats hosted a public workshop to explore the emerging science of the "social biology" of microbial communities. Workshop presentations and discussions embraced a wide spectrum of topics, experimental systems, and theoretical perspectives representative of the current, multifaceted exploration of the microbial frontier. Participants discussed ecological, evolutionary, and genetic factors contributing to the assembly, function, and stability of microbial communities; how microbial communities adapt and respond to environmental stimuli; theoretical and experimental approaches to advance this nascent field; and potential applications of knowledge gained from the study of microbial communities for the improvement of human, animal, plant, and ecosystem health and toward a deeper understanding of microbial diversity and evolution. The Social Biology of Microbial Communities: Workshop Summary further explains the happenings of the workshop.
Author: Food Forum
Publisher: National Academies Press
ISBN: 030926586X
Category : Medical
Languages : en
Pages : 197
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Book Description
The Food Forum convened a public workshop on February 22-23, 2012, to explore current and emerging knowledge of the human microbiome, its role in human health, its interaction with the diet, and the translation of new research findings into tools and products that improve the nutritional quality of the food supply. The Human Microbiome, Diet, and Health: Workshop Summary summarizes the presentations and discussions that took place during the workshop. Over the two day workshop, several themes covered included: The microbiome is integral to human physiology, health, and disease. The microbiome is arguably the most intimate connection that humans have with their external environment, mostly through diet. Given the emerging nature of research on the microbiome, some important methodology issues might still have to be resolved with respect to undersampling and a lack of causal and mechanistic studies. Dietary interventions intended to have an impact on host biology via their impact on the microbiome are being developed, and the market for these products is seeing tremendous success. However, the current regulatory framework poses challenges to industry interest and investment.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309131219
Category : Science
Languages : en
Pages : 330
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Book Description
Dr. Joshua Lederberg - scientist, Nobel laureate, visionary thinker, and friend of the Forum on Microbial Threats - died on February 2, 2008. It was in his honor that the Institute of Medicine's Forum on Microbial Threats convened a public workshop on May 20-21, 2008, to examine Dr. Lederberg's scientific and policy contributions to the marketplace of ideas in the life sciences, medicine, and public policy. The resulting workshop summary, Microbial Evolution and Co-Adaptation, demonstrates the extent to which conceptual and technological developments have, within a few short years, advanced our collective understanding of the microbiome, microbial genetics, microbial communities, and microbe-host-environment interactions.
Author: Sarangam Majumdar
Publisher: Springer
ISBN: 9789811574160
Category : Science
Languages : en
Pages : 175
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Book Description
This book introduces the concept of bacterial communication systems from a mathematical modeling point of view. It sheds light on the research undertaken in the last three decades, and the mathematical models that have been proposed to understand the underlying mechanism of such systems. These communication systems are related to quorum sensing mechanisms and quorum sensing regulated processes such as biofilm formation, gene expression, bioluminescence, swarming and virulence. The book further describes the phenomenon of noise, and discusses how noise plays a crucial role in gene expression and the quorum sensing circuit operationusing a set of tools like frequency domain analysis, power spectral density, stochastic simulation and the whitening effect. It also explores various aspects of synthetic biology (related to bacterial communication), such as genetic toggle switch, bistable gene regulatory networks, transcriptional repressor systems, pattern formation, synthetic cooperation, predator-prey synthetic systems, dynamical quorum sensing, synchronized quorum of genetic clocks, role of noise in synthetic biology, the Turing test and stochastic Turing test.
Author: D. Dhanasekaran
Publisher: CRC Press
ISBN: 1000353141
Category : Medical
Languages : en
Pages : 863
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Book Description
Microbiota are a promising and fascinating subject in biology because they integrate the microbial communities in humans, animals, plants, and the environment. In humans, microbiota are associated with the gut, skin, and genital, oral, and respiratory organs. The plant microbial community is referred to as "holobiont," and it is influential in the maintenance and health of plants, which themselves play a role in animal health and the environment. The contents of Microbiome-Host Interactions cover all areas as well as new research trends in the fields of plant, animal, human, and environmental microbiome interactions. The book covers microbiota in polar soil environments, in health and disease, in Caenorhabditis elegans, and in agroecosystems, as well as in rice root and actinorhizal root nodules, speleothems, and marine shallow-water hydrothermal vents. Moreover, this book provides comprehensive accounts of advanced next-generation DNA sequencing, metagenomic techniques, high-throughput 16S rRNA sequencing, and understanding nucleic acid sequence data from fungal, algal, viral, bacterial, cyanobacterial, actinobacterial, and archaeal communities using QIIME software (Quantitative Insights into Microbial Ecology). FEATURES Summarizes recent insight in microbiota and host interactions in distinct habitats, including Antarctic, hydrothermal vents, speleothems, oral, skin, gut, feces, reproductive tract, soil, root, root nodules, forests, and mangroves Illustrates the high-throughput amplicon sequencing, computational techniques involved in the microbiota analysis, downstream analysis and visualization, and multivariate analysis commonly used for microbiome analysis Describes probiotics and prebiotics in the composition of the gut microbiota, skin microbiome impact in dermatologic disease prevention, and microbial communities in the reproductive tract of humans and animals Presents information in a reachable way for students, teachers, researchers, microbiologists, computational biologists, and other professionals who are interested in strengthening or enlarging their knowledge about microbiome analysis with next-generation DNA sequencing in the different branches of the sciences
Author: Amedeo Amedei
Publisher:
ISBN: 9783039216475
Category : Electronic books
Languages : en
Pages : 1
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Book Description
[Increasing evidence suggests that microbiota and especially the gut microbiota (the microbes inhabiting the gut including bacteria, archaea, viruses, and fungi) plays a key role in human physiology and pathology. Recent findings indicate how dysbiosis-an imbalance in the composition and organization of microbial populations-could severely impact the development of different medical conditions (from metabolic to mood disorders), providing new insights into the comprehension of diverse diseases, such as IBD, obesity, asthma, autism, stroke, diabetes, and cancer. Given that microbial cells in the gut outnumber host cells, microbiota influences human physiology both functionally and structurally. Microbial metabolites bridge various-even distant-areas of the organism by way of the immune and hormone system. For instance, it is now clear that the mutual interaction between the gastrointestinal tract and the brain (gut-brain axis), often involves gut microbiota, indicating that the crosstalk between the organism and its microbial residents represents a fundamental aspect of both the establishment and maintenance of healthy conditions. Moreover, it is crucial to recognize that beyond the intestinal tract, microbiota populates other host organs and tissues (e.g., skin and oral mucosa). We have edited this eBook with the aim of publishing manuscripts focusing on the impact of microbiota in the development of different diseases and their associated treatments.].
