Microbial Adhesion and Aggregation PDF Download
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Author: K.C. Marshall
Publisher: Springer Science & Business Media
ISBN: 364270137X
Category : Science
Languages : en
Pages : 423
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Book Description
Author: K.C. Marshall
Publisher: Springer Science & Business Media
ISBN: 364270137X
Category : Science
Languages : en
Pages : 423
Get Book Here
Book Description
Author:
Publisher:
ISBN: 9780387139968
Category :
Languages : en
Pages : 423
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 423
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Book Description
Author: K.C. Marshall
Publisher: Springer
ISBN: 9783540139966
Category : Science
Languages : en
Pages : 426
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Book Description
Author:
Publisher:
ISBN: 9780387139968
Category :
Languages : en
Pages :
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Book Description
Author: R. J. Doyle
Publisher: ASM Press
ISBN:
Category : Science
Languages : en
Pages : 448
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Book Description
... an important milestone in the field of microbial adhesion and should be indispensable to all workers in that discipline Journal of Dispersion Science and Technology.
Author: Calleja
Publisher: CRC Press
ISBN: 1351082973
Category : Science
Languages : en
Pages : 282
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Book Description
This text covers in detail bacteria and yeasts, including an overall perspective of microbial aggregation as fundamental form and function, which is presented here to include systems still to be treated in detail.
Author: R. C. W. Berkeley
Publisher:
ISBN:
Category : Adhesion
Languages : en
Pages : 566
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Book Description
Author: Magnus Hook
Publisher: Springer Science & Business Media
ISBN: 1461229243
Category : Science
Languages : en
Pages : 205
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Book Description
This book contains the proceedings of the symposium on Microbial Adhesion and Invasion. The meeting was the fifth in a series of symposia initiated and sponsored by the Department of Biochemistry, University of Alabama at Birmingham. We gratefully acknowledge the generous financial support of the following institutions and companies. -Department of Biochemistry, University of Alabama at Birmingham, Birmingham, Alabama, USA - National Institutes of Health, Bethesda, Maryland, USA -Alfa Laval International, AB, Tumba, Sweden -Procter and Gamble, Cincinnati, Ohio, USA -Amgen Inc., Thousand Oaks, California, USA -Johnson and Johnson, New Brunswick, New Jersey, USA We would like to express our appreciation to Agneta Hook, Timo Kostiainen, Mary Homonylo McGavin, Martin McGavin, Cindy Patti, Joe Patti and Anna-Marja Saamanen for their time and hard work making this symposium a success; and special thanks to Kay Cooper and Wade Butcher for help with the management of the symposium and editorial assistance with this book.
Author: Roger Davies Klein
Publisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages : 149
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Book Description
Antibiotic-resistant bacterial infections are a serious and immediate threat to global public health. In the United States alone, over 2 million individuals develop antibiotic-resistant infections annually, resulting in 23,000 deaths and $20 billion in excess health care costs. Virulence factors that allow bacteria to invade and persist within the host are promising targets for novel antimicrobial agents that could be used to curb the spread of antibiotic resistance. Development of therapeutics that can selectively eliminate pathogenic bacteria while sparing the beneficial host microbiota requires a detailed molecular understanding of critical virulence factors that facilitate interactions between pathogens and their environments. Two such factors are Chaperone-Usher Pathway (CUP) pili, which mediate bacterial adhesion, and curli, which constitute the major extracellular matrix component of many biofilms. In this dissertation, I have elucidated the structure of two pilus adhesins thought to mediate colonization of the gastrointestinal tract and determined the mechanism of CsgE assembly factor function in curli biogenesis. CUP pili comprise hundreds of repeating structural subunits capped by an adhesin whose N-terminal lectin domain binds host receptors with stereochemical specificity, thus facilitating the colonization of specific host niches by Gram-negative bacteria. Using X-ray crystallography, I determined that the UclD adhesin on the F17-like pilus contains a transverse binding groove that binds O-glycans in the colonic crypts. Conversely, I found that the YehD adhesin contains a unique helix-loop-helix motif that can pivot open to reveal a deep hydrophobic pocket. Additional structural and genetic studies of the Yeh pilus rod reveal a tightly-wound right-handed helix that has maintained its biomechanical response to external force through purifying evolutionary selection. I have also utilized X-ray crystallography to elucidate the structure-activity relationship of high-affinity compounds that inhibit the binding of two additional pilus adhesins, FimH and FmlH, to the urinary tract during acute and chronic urinary tract infection. Finally, I have performed genetic and biochemical studies to elucidate the role of CsgE in bacterial biofilm formation. During curli biogenesis, I found that CsgE uses a series of specific and nonspecific electrostatic interactions to bind the major amyloid subunit CsgA and deliver it to the CsgG outer membrane pore, thus preventing premature aggregation and cellular toxicity. In aggregate, these findings have advanced our molecular understanding of bacterial adhesion during pathogenesis and illuminated novel pathways for the treatment of antibiotic-resistant infections.
