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Author: Andrew Delano Abbott
Publisher: W W Norton & Company Incorporated
ISBN: 9780393978148
Category : Social Science
Languages : en
Pages : 281
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Book Description
Abbott helps social science students discover what questions to ask. This exciting book is not about habits and the mechanics of doing social science research, but about habits of thinking that enable students to use those mechanics in new ways, by coming up with new ideas and combining them more effectively with old ones. Abbott organizes his book around general methodological moves, and uses examples from throughout the social sciences to show how these moves can open new lines of thinking. In each chapter, he covers several moves and their reverses (if these exist), discussing particular examples of the move as well as its logical and theoretical structure. Often he goes on to propose applications of the move in a wide variety of empirical settings. The basic aim of Methods of Discovery is to offer readers a new way of thinking about directions for their research and new ways to imagine information relevant to their research problems. Methods of Discovery is part of the Contemporary Societies series.
Author: Andrew Delano Abbott
Publisher: W W Norton & Company Incorporated
ISBN: 9780393978148
Category : Social Science
Languages : en
Pages : 281
Get Book Here
Book Description
Abbott helps social science students discover what questions to ask. This exciting book is not about habits and the mechanics of doing social science research, but about habits of thinking that enable students to use those mechanics in new ways, by coming up with new ideas and combining them more effectively with old ones. Abbott organizes his book around general methodological moves, and uses examples from throughout the social sciences to show how these moves can open new lines of thinking. In each chapter, he covers several moves and their reverses (if these exist), discussing particular examples of the move as well as its logical and theoretical structure. Often he goes on to propose applications of the move in a wide variety of empirical settings. The basic aim of Methods of Discovery is to offer readers a new way of thinking about directions for their research and new ways to imagine information relevant to their research problems. Methods of Discovery is part of the Contemporary Societies series.
Author: Herbert A. Simon
Publisher: Springer Science & Business Media
ISBN: 9401095213
Category : Science
Languages : en
Pages : 471
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Book Description
We respect Herbert A. Simon as an established leader of empirical and logical analysis in the human sciences while we happily think of him as also the loner; of course he works with many colleagues but none can match him. He has been writing fruitfully and steadily for four decades in many fields, among them psychology, logic, decision theory, economics, computer science, management, production engineering, information and control theory, operations research, confirmation theory, and we must have omitted several. With all of them, he is at once the technical scientist and the philosophical critic and analyst. When writing of decisions and actions, he is at the interface of philosophy of science, decision theory, philosophy of the specific social sciences, and inventory theory (itself, for him, at the interface of economic theory, production engineering and information theory). When writing on causality, he is at the interface of methodology, metaphysics, logic and philosophy of physics, systems theory, and so on. Not that the interdisciplinary is his orthodoxy; we are delighted that he has chosen to include in this book both his early and little-appreciated treatment of straightforward philosophy of physics - the axioms of Newtonian mechanics, and also his fine papers on pure confirmation theory.
Author: Krzysztof J. Cios
Publisher: Springer Science & Business Media
ISBN: 1461555892
Category : Computers
Languages : en
Pages : 508
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Book Description
Data Mining Methods for Knowledge Discovery provides an introduction to the data mining methods that are frequently used in the process of knowledge discovery. This book first elaborates on the fundamentals of each of the data mining methods: rough sets, Bayesian analysis, fuzzy sets, genetic algorithms, machine learning, neural networks, and preprocessing techniques. The book then goes on to thoroughly discuss these methods in the setting of the overall process of knowledge discovery. Numerous illustrative examples and experimental findings are also included. Each chapter comes with an extensive bibliography. Data Mining Methods for Knowledge Discovery is intended for senior undergraduate and graduate students, as well as a broad audience of professionals in computer and information sciences, medical informatics, and business information systems.
Author: Alleyn T. Plowright
Publisher: John Wiley & Sons
ISBN: 3527345299
Category : Medical
Languages : en
Pages : 396
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Book Description
The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.
Author: Alexandros Makriyannis
Publisher: CRC Press
ISBN: 082475767X
Category : Medical
Languages : en
Pages : 317
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Book Description
Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development. It considers key elements in the drug design cycle ranging from appropriateness of targets and disease models to compound characterization, safety, and efficacy and the role of protein crystallography in structure-based drug design.
Author: American Bar Association. House of Delegates
Publisher: American Bar Association
ISBN: 9781590318737
Category : Law
Languages : en
Pages : 216
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Book Description
The Model Rules of Professional Conduct provides an up-to-date resource for information on legal ethics. Federal, state and local courts in all jurisdictions look to the Rules for guidance in solving lawyer malpractice cases, disciplinary actions, disqualification issues, sanctions questions and much more. In this volume, black-letter Rules of Professional Conduct are followed by numbered Comments that explain each Rule's purpose and provide suggestions for its practical application. The Rules will help you identify proper conduct in a variety of given situations, review those instances where discretionary action is possible, and define the nature of the relationship between you and your clients, colleagues and the courts.
Author: Alexander Hillisch
Publisher: Springer Science & Business Media
ISBN: 9783764360818
Category : Medical
Languages : en
Pages : 314
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Book Description
Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.
Author: J. N. DeMeo
Publisher:
ISBN:
Category : Depositions
Languages : en
Pages : 1338
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Book Description
Author: Yukio Ohsawa
Publisher: Springer Science & Business Media
ISBN: 3662062305
Category : Computers
Languages : en
Pages : 420
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Book Description
Chance discovery means discovering chances - the breaking points in systems, the marketing windows in business, etc. It involves determining the significance of some piece of information about an event and then using this new knowledge in decision making. The techniques developed combine data mining methods for finding rare but important events with knowledge management, groupware, and social psychology. The reader will find many applications, such as finding information on the Internet, recognizing changes in customer behavior, detecting the first signs of an imminent earthquake, etc. This first book dedicated to chance discovery covers the state of the art in the theory and methods and examines typical scenarios, and it thus appeals to researchers working on new techniques and algorithms and also to professionals dealing with real-world applications.
Author: Seetharama D. Satyanarayanajois
Publisher: Humana Press
ISBN: 9781617790119
Category : Medical
Languages : en
Pages : 0
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Book Description
Research in the pharmaceutical sciences and medicinal chemistry has taken an important new direction in the past two decades with a focus on large molecules, especially peptides and proteins, as well as DNA therapeutics. In Drug Design and Discovery: Methods and Protocols, leading experts provide an in-depth view of key protocols that are commonly used in drug discovery laboratories. Covering both classic and cutting-edge techniques, this volume explores computational docking, quantitative structure-activity relationship (QSAR), peptide synthesis, labeling of peptides and proteins with fluorescent labels, DNA-microarray, zebrafish model for drug screening, and other analytical screening and biological assays that are routinely used during the drug discovery process. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and accessible, Drug Design and Discovery: Methods and Protocols serve as a vital laboratory reference for pharmaceutical chemists, medicinal chemists, and pharmacologists as well as for molecular biologists.
