Protein Crystallography

Protein Crystallography PDF Author: Alexander Wlodawer
Publisher: Humana Press
ISBN: 9781493969982
Category : Science
Languages : en
Pages : 672

Get Book Here

Book Description
This volume provides methods for modern macromolecular crystallography, including all steps leading to crystal structure determination and analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein Crystallography aims to ensure successful results in the further study of this vital field.

Protein Crystallography

Protein Crystallography PDF Author: Alexander Wlodawer
Publisher: Humana Press
ISBN: 9781493969982
Category : Science
Languages : en
Pages : 672

Get Book Here

Book Description
This volume provides methods for modern macromolecular crystallography, including all steps leading to crystal structure determination and analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein Crystallography aims to ensure successful results in the further study of this vital field.

Neutron Crystallography in Structural Biology

Neutron Crystallography in Structural Biology PDF Author:
Publisher: Academic Press
ISBN: 0128192143
Category : Science
Languages : en
Pages : 408

Get Book Here

Book Description
Neutron Crystallography in Structural Biology, Volume 634, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this updated release include Fundamentals of neutron crystallography in structural biology, Large crystal growth for neutron protein crystallography, Prospects for membrane protein crystals in NMX, IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor, The macromolecular neutron diffractometer at the spallation neutron source, Current status and near future plan of neutron protein crystallography at J-PARC, Neutron macromolecular crystallography at the European spallation source, and much more.

Methods in Macromolecular Crystallography

Methods in Macromolecular Crystallography PDF Author: North Atlantic Treaty Organization. Scientific Affairs Division
Publisher: IOS Press
ISBN: 9781586030803
Category : Science
Languages : en
Pages : 220

Get Book Here

Book Description
This volume contains 20 papers from two courses ("Methods for Macromolecular Crystallography" and "Chemical Prospective in Crystallography of Molecular Biology") held during the late spring of 2000 in Reice, Italy. The papers discuss crystals, synchrotrons, detector development, data processing, ab initio phasing and high and low resolution, molecular placement, experimental phase measurement, density modification methods, map improvements, interpretation of electron density maps, automatic structure determination, and the dissection of ultra-high resolution structures. c. Book News Inc.

Macromolecular Crystallography

Macromolecular Crystallography PDF Author: Charles W. Carter
Publisher: Gulf Professional Publishing
ISBN: 9780121827779
Category : Computer simulation
Languages : en
Pages : 754

Get Book Here

Book Description
Annotation Accurate molecular structures is vital for rational drug design and for structure based functional studies directed toward the development of effective therapeutic agents and drugs. Crystallography can reliably predict structure, both in terms of folding and atomic details of bonding. * Phases * Map interpretation and refinement * Analysis and software.

Macromolecular Crystallography

Macromolecular Crystallography PDF Author: Maria Armenia Carrondo
Publisher: Springer
ISBN: 9400725302
Category : Science
Languages : en
Pages : 213

Get Book Here

Book Description
This volume is a collection of the contributions presented at the 42nd Erice Crystallographic Course whose main objective was to train the younger generation on advanced methods and techniques for examining structural and dynamic aspects of biological macromolecules. The papers review the techniques used to study protein assemblies and their dynamics, including X-ray diffraction and scattering, electron cryo-electron microscopy, electro nanospray mass spectrometry, NMR, protein docking and molecular dynamics. A key theme throughout the book is the dependence of modern structural science on multiple experimental and computational techniques, and it is the development of these techniques and their integration that will take us forward in the future.

Principles of Protein X-ray Crystallography

Principles of Protein X-ray Crystallography PDF Author: Jan Drenth
Publisher: Springer Science & Business Media
ISBN: 1475730926
Category : Science
Languages : en
Pages : 355

Get Book Here

Book Description
New textbooks at all levels of chemistry appear with great regularity. Some fields such as basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research that is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive intro ductions to their fields. These should serve the needs of one-semester or one-quarter graduate courses in chemistry and biochemistry. In some cases, the availability of texts in active research areas should help stimulate the creation of new courses. Charles R. Cantor v Preface to the Second Edition Since the publication of the previous edition in 1994, X-ray crystallography of proteins has advanced by improvements in existing techniques and by addition of new techniques.

Protein Crystallography in Drug Discovery, Volume 20

Protein Crystallography in Drug Discovery, Volume 20 PDF Author: Robert E. Babine
Publisher: John Wiley & Sons
ISBN: 9783527306787
Category : Medical
Languages : en
Pages : 284

Get Book Here

Book Description
The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.

Biomolecular Crystallography

Biomolecular Crystallography PDF Author: Bernhard Rupp
Publisher: Garland Science
ISBN: 1134064195
Category : Science
Languages : en
Pages : 832

Get Book Here

Book Description
Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography. Illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.

Macromolecular Crystallography Protocols, Volume 1

Macromolecular Crystallography Protocols, Volume 1 PDF Author: Sylvie Doublie
Publisher: Humana Press
ISBN: 9781617374753
Category : Science
Languages : en
Pages : 0

Get Book Here

Book Description
Macromolecular Crystallography Protocols, now in two volumes, examines major developments that have occurred since publication of the acclaimed first edition nearly a decade ago. Volume 1 is composed of detailed protocols for the preparation and optimization of crystals. Volume 2 complements the first volume by addressing laboratory techniques for crystal handling and structural characterization. The volume concludes with a survey of available crystallographic software.

Macromolecular Crystallography

Macromolecular Crystallography PDF Author: Mark R. Sanderson
Publisher: Oxford University Press
ISBN: 0198520972
Category : Language Arts & Disciplines
Languages : en
Pages : 293

Get Book Here

Book Description
Macromolecular crystallography is the study of macromolecules using X-ray crystallographic techniques to determine their molecular structure. This title synthesises contributions from a team of internationally recognized leaders, offering chapters on conventional and high-throughput methods.