Méthodologie pour l'IRM abdominale du petit animal à champ magnétique élevé PDF Download
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Author: Loredana Maria Baboi
Publisher:
ISBN:
Category :
Languages : fr
Pages : 166
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Book Description
L’histoire naturelle des lésions hépatiques des tumeurs endocrines digestives est aujourd’hui peu connue. L’existence d’un modèle animal reproduisant les caractéristiques de la dissémination métastatique hépatique des tumeurs endocrines entéro-pancréatiques humaines est donc particulièrement précieuse. Le caractère non invasif de l’imagerie par résonance magnétique fait de cette technique une modalité particulièrement bien adaptée à l’étude de ces lésions hépatiques. Dans ce contexte, nos travaux ont consisté à évaluer le seuil de détection et à caractériser les lésions du foie dans un modèle de souris athymic nude. Un protocole d’IRM dédié, fondé sur des séquences pondérées T2 et des stratégies de synchronisation cardio-respiratoires optimisées pour des champs magnétiques élevés, a été développé et validé au cours d’un suivi longitudinal. Ces travaux ont été complétés par des développements méthodologiques destinés à accélérer l’acquisition des images pondérées T2 et réaliser des images pondérées T1 synchronisées, indépendamment de la période respiratoire de la souris. Enfin, la validation d’un dispositif de synchronisation utilisant un capteur optique fibré a été réalisée
Author: Loredana Maria Baboi
Publisher:
ISBN:
Category :
Languages : fr
Pages : 166
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Book Description
L’histoire naturelle des lésions hépatiques des tumeurs endocrines digestives est aujourd’hui peu connue. L’existence d’un modèle animal reproduisant les caractéristiques de la dissémination métastatique hépatique des tumeurs endocrines entéro-pancréatiques humaines est donc particulièrement précieuse. Le caractère non invasif de l’imagerie par résonance magnétique fait de cette technique une modalité particulièrement bien adaptée à l’étude de ces lésions hépatiques. Dans ce contexte, nos travaux ont consisté à évaluer le seuil de détection et à caractériser les lésions du foie dans un modèle de souris athymic nude. Un protocole d’IRM dédié, fondé sur des séquences pondérées T2 et des stratégies de synchronisation cardio-respiratoires optimisées pour des champs magnétiques élevés, a été développé et validé au cours d’un suivi longitudinal. Ces travaux ont été complétés par des développements méthodologiques destinés à accélérer l’acquisition des images pondérées T2 et réaliser des images pondérées T1 synchronisées, indépendamment de la période respiratoire de la souris. Enfin, la validation d’un dispositif de synchronisation utilisant un capteur optique fibré a été réalisée
Author: Ulrich Sigwart
Publisher: Thieme-Stratton Corporation
ISBN: 9780865771468
Category : Angiocardiography
Languages : en
Pages : 327
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Book Description
Author: Michael T. Gyepes
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 404
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Book Description
Author: Pere Ginés
Publisher: John Wiley & Sons
ISBN: 1405143703
Category : Medical
Languages : en
Pages : 464
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Book Description
There has been very little written on the interaction of the liverand kidney. This book addresses the increasing incidence andsignificance of diseases, such as ascites, renal dysfunction,cirrhosis and hypertension where both organs are involved. This textbook is essential, even for confirmed practitioners andcontains current information regarding treatment and therapy forpatients with cirrhosis and ascites, clearly and effectivelypresented by the top international experts within this field. The second edition is entirely revised and updated and placesgreater emphasis on therapy.
Author: Charles H. Hollenberg
Publisher: New York : Raven Press
ISBN:
Category : Medical
Languages : en
Pages : 336
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Book Description
Abstract: The proceedings of a 1982 international conference covers 33 review articles on research findings and the current state of knowledge of various metabolic and mechanistic aspects of the associations between the adipocyte fat cell and obesity. The articles address various facets of adipose cell growth and development; insulin action; lipid assimilation and lipoprotein and cholesterol metabolism in adipose tissue; lipolysis in adipocytes; and energy expenditure. The role of adipose tissue as a model system for the study of mechanisms of insulin action is highlighted by evidence of new cellular mediators. Recent insights in triglyceride assimilation regulation by lipoprotein lipase and fatty acid release through the lipolytic cascade are discussed. Other topics include the role of lipocytes in cholesterol turnover, the relationship of cholesterol metabolism to lipoprotein turnover and catabolism, and aspects of energy balance and thermoregulation in obesity. (wz).
Author:
Publisher: World Scientific
ISBN: 9813232242
Category : Medical
Languages : en
Pages : 1555
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Book Description
The Encyclopedia of Medical Robotics combines contributions in four distinct areas of Medical robotics, namely: Minimally Invasive Surgical Robotics, Micro and Nano Robotics in Medicine, Image-guided Surgical Procedures and Interventions, and Rehabilitation Robotics. The volume on Minimally Invasive Surgical Robotics focuses on robotic technologies geared towards challenges and opportunities in minimally invasive surgery and the research, design, implementation and clinical use of minimally invasive robotic systems. The volume on Micro and Nano robotics in Medicine is dedicated to research activities in an area of emerging interdisciplinary technology that is raising new scientific challenges and promising revolutionary advancement in applications such as medicine and biology. The size and range of these systems are at or below the micrometer scale and comprise assemblies of micro and nanoscale components. The volume on Image-guided Surgical Procedures and Interventions focuses primarily on the use of image guidance during surgical procedures and the challenges posed by various imaging environments and how they related to the design and development of robotic systems as well as their clinical applications. This volume also has significant contributions from the clinical viewpoint on some of the challenges in the domain of image-guided interventions. Finally, the volume on Rehabilitation Robotics is dedicated to the state-of-the-art of an emerging interdisciplinary field where robotics, sensors, and feedback are used in novel ways to re-learn, improve, or restore functional movements in humans.Volume 1, Minimally Invasive Surgical Robotics, focuses on an area of robotic applications that was established in the late 1990s, after the first robotics-assisted minimally invasive surgical procedure. This area has since received significant attention from industry and researchers. The teleoperated and ergonomic features of these robotic systems for minimally invasive surgery (MIS) have been able to reduce or eliminate most of the drawbacks of conventional (laparoscopic) MIS. Robotics-assisted MIS procedures have been conducted on over 3 million patients to date — primarily in the areas of urology, gynecology and general surgery using the FDA approved da Vinci® surgical system. The significant commercial and clinical success of the da Vinci® system has resulted in substantial research activity in recent years to reduce invasiveness, increase dexterity, provide additional features such as image guidance and haptic feedback, reduce size and cost, increase portability, and address specific clinical procedures. The area of robotic MIS is therefore in a state of rapid growth fueled by new developments in technologies such as continuum robotics, smart materials, sensing and actuation, and haptics and teleoperation. An important need arising from the incorporation of robotic technology for surgery is that of training in the appropriate use of the technology, and in the assessment of acquired skills. This volume covers the topics mentioned above in four sections. The first section gives an overview of the evolution and current state the da Vinci® system and clinical perspectives from three groups who use it on a regular basis. The second focuses on the research, and describes a number of new developments in surgical robotics that are likely to be the basis for the next generation of robotic MIS systems. The third deals with two important aspects of surgical robotic systems — teleoperation and haptics (the sense of touch). Technology for implementing the latter in a clinical setting is still very much at the research stage. The fourth section focuses on surgical training and skills assessment necessitated by the novelty and complexity of the technologies involved and the need to provide reliable and efficient training and objective assessment in the use of robotic MIS systems.In Volume 2, Micro and Nano Robotics in Medicine, a brief historical overview of the field of medical nanorobotics as well as the state-of-the-art in the field is presented in the introductory chapter. It covers the various types of nanorobotic systems, their applications and future directions in this field. The volume is divided into three themes related to medical applications. The first theme describes the main challenges of microrobotic design for propulsion in vascular media. Such nanoscale robotic agents are envisioned to revolutionize medicine by enabling minimally invasive diagnostic and therapeutic procedures. To be useful, nanorobots must be operated in complex biological fluids and tissues, which are often difficult to penetrate. In this section, a collection of four papers review the potential medical applications of motile nanorobots, catalytic-based propelling agents, biologically-inspired microrobots and nanoscale bacteria-enabled autonomous drug delivery systems. The second theme relates to the use of micro and nanorobots inside the body for drug-delivery and surgical applications. A collection of six chapters is presented in this segment. The first chapter reviews the different robot structures for three different types of surgery, namely laparoscopy, catheterization, and ophthalmic surgery. It highlights the progress of surgical microrobotics toward intracorporeally navigated mechanisms for ultra-minimally invasive interventions. Then, the design of different magnetic actuation platforms used in micro and nanorobotics are described. An overview of magnetic actuation-based control methods for microrobots, with eventually biomedical applications, is also covered in this segment. The third theme discusses the various nanomanipulation strategies that are currently used in biomedicine for cell characterization, injection, fusion and engineering. In-vitro (3D) cell culture has received increasing attention since it has been discovered to provide a better simulation environment of in-vivo cell growth. Nowadays, the rapid progress of robotic technology paves a new path for the highly controllable and flexible 3D cell assembly. One chapter in this segment discusses the applications of micro-nano robotic techniques for 3D cell culture using engineering approaches. Because cell fusion is important in numerous biological events and applications, such as tissue regeneration and cell reprogramming, a chapter on robotic-tweezers cell manipulation system to achieve precise laser-induced cell fusion using optical trapping has been included in this volume. Finally, the segment ends with a chapter on the use of novel MEMS-based characterization of micro-scale tissues instead of mechanical characterization for cell lines studies.Volume 3, Image-guided Surgical Procedures and Interventions, focuses on several aspects ranging from understanding the challenges and opportunities in this domain, to imaging technologies, to image-guided robotic systems for clinical applications. The volume includes several contributions in the area of imaging in the areas of X-Ray fluoroscopy, CT, PET, MR Imaging, Ultrasound imaging, and optical coherence tomography. Ultrasound-based diagnostics and therapeutics as well as ultrasound-guided planning and navigation are also included in this volume in addition to multi-modal imaging techniques and its applications to surgery and various interventions. The application of multi-modal imaging and fusion in the area of prostate biopsy is also covered. Imaging modality compatible robotic systems, sensors and actuator technologies for use in the MRI environment are also included in this work., as is the development of the framework incorporating image-guided modeling for surgery and intervention. Finally, there are several chapters in the clinical applications domain covering cochlear implant surgery, neurosurgery, breast biopsy, prostate cancer treatment, endovascular interventions, neurovascular interventions, robotic capsule endoscopy, and MRI-guided neurosurgical procedures and interventions.Volume 4, Rehabilitation Robotics, is dedicated to the state-of-the-art of an emerging interdisciplinary field where robotics, sensors, and feedback are used in novel ways to relearn, improve, or restore functional movements in humans. This volume attempts to cover a number of topics relevant to the field. The first section addresses an important activity in our daily lives: walking, where the neuromuscular system orchestrates the gait, posture, and balance. Conditions such as stroke, vestibular deficits, or old age impair this important activity. Three chapters on robotic training, gait rehabilitation, and cooperative orthoses describe the current works in the field to address this issue. The second section covers the significant advances in and novel designs of soft actuators and wearable systems that have emerged in the area of prosthetic lower limbs and ankles in recent years, which offer potential for both rehabilitation and human augmentation. These are described in two chapters. The next section addresses an important emphasis in the field of medicine today that strives to bring rehabilitation out from the clinic into the home environment, so that these medical aids are more readily available to users. The current state-of-the-art in this field is described in a chapter. The last section focuses on rehab devices for the pediatric population. Their impairments are life-long and rehabilitation robotics can have an even bigger impact during their lifespan. In recent years, a number of new developments have been made to promote mobility, socialization, and rehabilitation among the very young: the infants and toddlers. These aspects are summarized in two chapters of this volume.
Author: Ian Macnab
Publisher: Lippincott Williams & Wilkins
ISBN:
Category : Medical
Languages : en
Pages : 534
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Book Description
Author: Charles Hayter
Publisher: McGill-Queen's Press - MQUP
ISBN: 9780773528697
Category : Canada
Languages : en
Pages : 298
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Book Description
A national study of the history of cancer in Canada.
Author: Auguste Wackenheim
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 638
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Book Description
Author: Meena Upadhyaya
Publisher: Springer Science & Business Media
ISBN: 3642328644
Category : Medical
Languages : en
Pages : 711
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Book Description
Neurofibromatosis type 1 (NF1), caused by mutational inactivation of the NF1 tumour suppressor gene, is one of the most common dominantly inherited human disorders, affecting 1 in 3000 individuals worldwide. This book presents in concise fashion, but as comprehensively as possible, our current state of knowledge on the molecular genetics, molecular biology and cellular biology of this tumour predisposition syndrome. Written by internationally recognized experts in the field, the 44 chapters that constitute this edited volume provide the reader with a broad overview of the clinical features of the disease, the structure and expression of the NF1 gene, its germ line and somatic mutational spectra and genotype-phenotype relationships, the structure and function of its protein product (neurofibromin), NF1 modifying loci, the molecular pathology of NF1-associated tumours, animal models of the disease, psycho-social aspects and future prospects for therapeutic treatment.
