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Author:
Publisher: Academic Press
ISBN: 0128245700
Category : Science
Languages : en
Pages : 438
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Book Description
Metal-Catalyzed Asymmetric Hydrogenation, Volume 68 in the Advances in Catalysis series, fills the gap between journal papers and textbooks across diverse areas of catalysis research. For more than 60 years, this series has recorded and presented the latest progress in the field of catalysis, giving the scientific community comprehensive and authoritative reviews. Chapters in this new release include Asymmetric hydrogenation of functionalized olefins, Asymmetric hydrogenation of unfunctionalized olefins or with poorly coordinative groups, Asymmetric hydrogenation of imines, Asymmetric hydrogenation of ketones, Asymmetric hydrogenation in industry, and Computational insights into metal-catalyzed asymmetric hydrogenation. This series is an invaluable and comprehensive resource for chemical engineers and chemists working in the field of catalysis in both academia and industry, with this release focusing on solid acids, surface acidity and heterogeneous acid catalysis. Contains authoritative reviews written by experts in the field Explores topics that reflect progress in the field, such as catalyst synthesis, catalyst characterization, catalytic chemistry, reaction engineering, computational chemistry and physics Provides insightful and critical articles that are fully edited to suit various backgrounds
Author:
Publisher: Academic Press
ISBN: 0128245700
Category : Science
Languages : en
Pages : 438
Get Book Here
Book Description
Metal-Catalyzed Asymmetric Hydrogenation, Volume 68 in the Advances in Catalysis series, fills the gap between journal papers and textbooks across diverse areas of catalysis research. For more than 60 years, this series has recorded and presented the latest progress in the field of catalysis, giving the scientific community comprehensive and authoritative reviews. Chapters in this new release include Asymmetric hydrogenation of functionalized olefins, Asymmetric hydrogenation of unfunctionalized olefins or with poorly coordinative groups, Asymmetric hydrogenation of imines, Asymmetric hydrogenation of ketones, Asymmetric hydrogenation in industry, and Computational insights into metal-catalyzed asymmetric hydrogenation. This series is an invaluable and comprehensive resource for chemical engineers and chemists working in the field of catalysis in both academia and industry, with this release focusing on solid acids, surface acidity and heterogeneous acid catalysis. Contains authoritative reviews written by experts in the field Explores topics that reflect progress in the field, such as catalyst synthesis, catalyst characterization, catalytic chemistry, reaction engineering, computational chemistry and physics Provides insightful and critical articles that are fully edited to suit various backgrounds
Author: Lee J Higham
Publisher: Royal Society of Chemistry
ISBN: 1837672741
Category : Science
Languages : en
Pages : 304
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Book Description
This annual review of the literature provides a comprehensive and critical survey of a vast field of study involving organophosphorus compounds, ranging from phosphines and their chalcogenide derivatives, phosphonium salts and P-ylides, to tervalent and quinquevalent phosphorus acid derivatives and penta- and hexa-coordinated phosphorus compounds. Recent developments in applications as reagents in green synthetic procedures are also given. With an emphasis on interdisciplinary content, this book will appeal to the worldwide organic chemistry and engineering research communities.
Author:
Publisher: Elsevier
ISBN: 0443294216
Category : Science
Languages : en
Pages : 400
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Book Description
Advances in Organometallic Chemistry, Volume 81 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Specific chapters cover Recent Advances in the Catalytic Applications of NHC-Early Abundant Metals (Fe, Mn, Co) Complexes, A Guide to Non-Carbonyl, Non-Isocyano Organometallic Chemistry of Technetium-99 from Discovery to 2023, and Cyclopentadienyl, Amidinate (CPAM) Complexes of Groups 4 - 6 Transition Metals. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Author: Ian Michael Sutherland
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Shengming Ma
Publisher: Springer Science & Business Media
ISBN: 3642194729
Category : Science
Languages : en
Pages : 368
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Book Description
Qi-Lin Zhou and Jian-Hua Xie: Chiral Spiro Catalysts.- Fuk Loi Lam, Fuk Yee Kwong and Albert S. C. Chan: Chiral Phosphorus Ligands with Interesting Properties and Practical Applications.- Jiang Pan, Hui-Lei Yu, Jian-He Xu, Guo-Qiang Lin: Advances in Biocatalysis: Enzymatic Reactions and Their Applications.- Mei-Xiang Wang: Enantioselective Biotransformations of Nitriles.- Man Kin Wong, Yiu Chung Yip and Dan Yang: Asymmetric Epoxidation Catalyzed by Chiral Ketones.- W. J. Liu, N. Li and L. Z. Gong: Asymmetric Organocatalysis.- Qing-Hua Fan and Kuiling Ding: Enantioselective Catalysis with Structurally Tunable Immobilized Catalysts.- Chang-Hua Ding, Xue-Long Hou: Transition Metal-Catalyzed Asymmetric Allylation.- Jian Zhou and Yong Tang: Enantioselective Reactions with Trisoxazolines.- Xiang-Ping Hu, Duo-Sheng Wang, Chang-Bin Yu, Yong-Gui Zhou, and Zhuo Zheng: Adventure in Asymmetric Hydrogenation: Synthesis of Chiral Phosphorus Ligands and Asymmetric Hydrogenation of Heteroaromtics.
Author: Virginie Ratovelomanana-Vidal
Publisher: John Wiley & Sons
ISBN: 3527822313
Category : Science
Languages : en
Pages : 400
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Book Description
Discover the latest developments in homogeneous asymmetric (transfer) hydrogenation with this up-to-date resource Asymmetric Hydrogenation and Transfer Hydrogenation delivers a current and cutting-edge investigation of homogenous asymmetric hydrogenation and transfer hydrogenation reactions of prochiral substrates by using organometallic catalysts (like ruthenium, rhodium, iridium, iron, and copper) and organic catalysts. Distinguished researchers and editors Virginie Ratovelomanana-Vidal and Phannarath Phansavath also offer readers a comprehensive walkthrough of substituted ketones through dynamic kinetic resolution, as well a presentation of the mechanisms and application of asymmetric hydrogenation reactions to the synthesis of biologically relevant compounds. The book comprehensively details its complex subject matter clearly and plainly and covers everything from catalyst development and reactions to mechanisms and applications in academia and industry. The papers included within come from many of the leading voices in their respective fields and represent the newest and best research available today. Compiled for researchers and private-industry chemists alike, Asymmetric Hydrogenation and Transfer Hydrogenation also discusses a wide variety of other topics like: A discussion of the development of chiral metal catalysts for asymmetric transfer hydrogenation Several examinations of asymmetric transfer hydrogenation of a variety of chemical groups, including ketones, aryl and heteroaryl ketones, substituted ketones, and heteroaromatic compounds, akenes, and imines An exploration of the mechanism of asymmetric hydrogenation and continuous flow asymmetric hydrogenation A full and thorough treatment of the industrial applications of asymmetric hydrogenation Perfect for catalytic chemists, chemists working on or with organometallics, organic chemists, natural product chemists, pharmaceutical chemists, medicinal chemists, and industrial chemists, Asymmetric Hydrogenation and Transfer Hydrogenation also belongs on the bookshelves of research and university institutes and libraries who wish to expand their selection on a topic fundamental to organic synthesis.
Author: Julien Jean-Marc Daubignard
Publisher:
ISBN: 9789402800357
Category :
Languages : en
Pages : 0
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Book Description
Author: Mingxin Chang
Publisher:
ISBN:
Category : Amines
Languages : en
Pages : 122
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Book Description
Author: Jialin Wen
Publisher:
ISBN:
Category : Hydrogen bonding
Languages : en
Pages : 155
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Book Description
Hydrogen bonding has been widely observed in biosynthesis and enzyme catalysis. It plays an important role in such fields as molecular recognition, supramolecular chemistry and small molecule catalysis. A new concept of organocatalysis emerged in recent two decades. Hydrogen bonding is the keystone for thiourea catalysis or phosphoric acid catalysis. With high turnover numbers and excellent enantioselectivity, transition metal catalysis not only is the arts in academia, but also find its merit in industrial application. Homogeneous hydrogenation, among many successful transition metal catalyzed reactions, has been serving the synthetic communities for many years, both in academia or in industry. The success of secondary interaction and hydrogen bonding offer us an alternative: the combination of hydrogen bonding and steric hindrance help to create a chiral environment in which substrates could be reduced efficiently. Guided by this rationale, a ferrocene-based bisphosphine/thiourea ligand, ZhaoPhos was synthesized in our group. It was applied in the asymmetric hydrogenation of nitroolefins with hydrogen bonding between the ligand and substrates. Thiourea-carbonyl hydrogen bonding is another model of non-covalent interaction. Therefore, the asymmetric hydrogenation of unsaturated carbonyl compounds is also practical. Besides neutral compounds, ionic unsaturated substrates could form non-covalent interactions with thiourea through anion binding as well. It makes the asymmetric reduction of iminium ions and N-heteroaromatics (quinolines, isoquinolines and indoles) possible. These type of unsaturated compounds were challenging for traditional transition metal catalyzed hydrogenation. They could now be achieved with high enantioselectivity with a rhodium/ZhaoPhos complex. An outer-sphere mechanism involving hydride transfer was proposed since these substrates were thought to lack of coordinating ability to the metal center. As a traditional catalytic system, rhodium/bisphosphine complexes have been applied to catalyze hydrogenation of C=C bonds in a long time. The application in hydrogenation of non- or weak coordinating unsaturated compounds changed our view towards of this class of complexes. In the meanwhile, the role of hydrogen bonding is still a mechanistically unexplored area: what is the geometry of the ligand-substrate complex? How does the hydrogen bonding influence the activation energy in the transition state? Many in-depth studies are needed in the future.
Author: Hongyu Zhong
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Transition metal-catalyzed hydrogenation reactions represent one of the cornerstones in homogeneous catalysis. The asymmetric hydrogenation of unsaturated molecules is an atom-economical method for the synthesis of enantio-enriched compounds and is of particular interest to the pharmaceutical, agrochemical and fine chemical industries. Catalysts based on second- and third-row transition metals, including rhodium, iridium and ruthenium, have been intensively studied in the past five decades and applied widely in industries. Thorough mechanistic studies have been carried out, facilitating catalyst designs and process optimizations. There has been a growing interest in developing relatively Earth abundant, 3d transition metal hydrogenation catalysts based on manganese, iron, cobalt and nickel as alternatives to 4d and 5d transition metals owing to their reduced cost, uninterrupted supply chains and relatively lower toxicity. First-row metals have kinetically and thermodynamically accessible oxidation states separated by one-electrons, which offers opportunities for catalyst designs with new reaction mechanisms. Despite recent progress, the understandings of catalyst speciation upon in situ activation are still limited. Elucidating the coordination chemistry, oxidation states and spin states of active catalysts is of fundamental importance to inform catalyst designs and improve the catalytic performance of first-row metals.In this dissertation, the synthesis, characterization and mechanistic studies of a host of cobalt catalysts for the asymmetric hydrogenation of carbon?carbon double bonds will be introduced. In particular, cobalt catalysts supported by chiral bidentate phosphine ligands have been identified as a ?privileged? class of catalysts and will be the focus of this dissertation.The cobalt-catalyzed asymmetric hydrogenation affording the epilepsy medication, levetiracetam, has been developed and applied to a 200-gram, pilot scale hydrogenation. The unique stability and high activity of reduced cobalt catalysts in protic solvents represent major advances for first-row alkene hydrogenation catalysts. The reaction mechanisms of enamide asymmetric hydrogenation with the formally cobalt(0) catalysts were investigated by experimental and computational methods. The enantioselectivity originates from the different reactivity of a pair of diastereomeric bis(phosphine)cobalt(0)?enamide complexes with H2. The cobalt-catalyzed asymmetric hydrogenation of ?, ?-unsaturated carboxylic acids with unusual homolytic H2 cleavage has been achieved, affording chiral acid products including Naproxen, Flurbiprofen and an L-DOPA precursor. The reactions between bis(phosphine)cobalt(II) dialkyl precatalysts and alcohols have been investigated and the bis(phosphine)Co(II) alkoxide products remained catalytically active. A cobalt-promoted methanol dehydrogenation reaction was also studied. The long-sought-after cobalt analogs of Schrock-Osborn type rhodium catalysts have been synthesized and characterized. A cationic bis(phosphine)cobalt(I) arene catalyst was discovered to be highly active for the asymmetric hydrogenation affording the type 2 diabetes medication, Sitagliptin. The ligand substitution of bis(phosphine)cobalt(0)(diene) catalysts was investigated using kinetic methods establishing a dissociative substitution mechanism. Solid state parameters and electronic structure studies imply their alternative assignment as bis(phosphine)cobalt(II) metallacyclopropane, providing a rationale for the unique protic stability. A family of cobalt precatalysts supported by the bis(phosphine), (R,R)-BenzP*, has been synthesized and characterized. The magnetic properties of dimeric bis(phosphine)Co(I)monochloride precatalysts have also been elucidated.
