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Author: Jerzy Adamski
Publisher: Academic Press
ISBN: 0128127856
Category : Medical
Languages : en
Pages : 266
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Book Description
Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression. This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research. Focuses on metabolomics in translational and medical research Provides basics for, and concepts of, contemporary translational personalized medicine research with metabolomics Brings the major recent progresses on design, analytics, biostatistics and bioinformatics relating to the success of metabolomics research
Author: Jerzy Adamski
Publisher: Academic Press
ISBN: 0128127856
Category : Medical
Languages : en
Pages : 266
Get Book
Book Description
Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression. This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research. Focuses on metabolomics in translational and medical research Provides basics for, and concepts of, contemporary translational personalized medicine research with metabolomics Brings the major recent progresses on design, analytics, biostatistics and bioinformatics relating to the success of metabolomics research
Author: Alessandra Sussulini
Publisher: Springer
ISBN: 3319476564
Category : Science
Languages : en
Pages : 350
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Book Description
This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.
Author: Jens Nielsen
Publisher: Springer Science & Business Media
ISBN: 3540747192
Category : Science
Languages : en
Pages : 292
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Book Description
Giving a fresh, substantial and in-depth overview of the topic, this book brings together the latest results in the field of metabolomics. It comprehensively presents the current state of the metabolomics field by underscoring experimental methods, analysis techniques, standardization practices, and advances in specific model systems. As a result, it helps to significantly broaden our perspective on the principles and strategies underpinning this emerging field.
Author: Aihua Zhang
Publisher: John Wiley & Sons
ISBN: 3527835741
Category : Science
Languages : en
Pages : 292
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Book Description
Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc. Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.
Author:
Publisher:
ISBN: 9783036525822
Category : Science
Languages : en
Pages : 178
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Book Description
Author: Robert Winkler
Publisher: Royal Society of Chemistry
ISBN: 1788017218
Category : Science
Languages : en
Pages : 460
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Book Description
Metabolomics and proteomics allow deep insights into the chemistry and physiology of biological systems. This book expounds open-source programs, platforms and programming tools for analysing metabolomics and proteomics mass spectrometry data. In contrast to commercial software, open-source software is created by the academic community, which facilitates the direct interaction between users and developers and accelerates the implementation of new concepts and ideas. The first section of the book covers the basics of mass spectrometry, experimental strategies, data operations, the open-source philosophy, metabolomics, proteomics and statistics/ data mining. In the second section, active programmers and users describe available software packages. Included tutorials, datasets and code examples can be used for training and for building custom workflows. Finally, every reader is invited to participate in the open science movement.
Author: Karsten Suhre
Publisher: Springer Science & Business Media
ISBN: 1461416892
Category : Medical
Languages : en
Pages : 328
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Book Description
This book is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.
Author: Xianquan Zhan
Publisher: BoD – Books on Demand
ISBN: 1839690836
Category : Science
Languages : en
Pages : 170
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Book Description
Metabolomics is the methodology and theory to study the metabolome, including targeted approaches based on selected/multiple reaction monitoring (SRM/MRM) and untargeted approaches based on nuclear magnetic resonance (NMR) or mass spectrometry (MS). The metabolome contains all metabolites derived from sugars, lipids, proteins, and nucleic acids in a given biological system, tissue, cell, or body fluid in a metabolic network system. Metabolomic variations directly link to molecular mechanisms of a disease, reliable therapeutic targets, and effective biomarkers for prediction, diagnosis, and prognostic assessment of disease. This book presents new advances in the concept and methodology of metabolomics, as well as applications of metabolomics in the research and practice of medical and life sciences.
Author: Raúl González-Domínguez
Publisher: Springer Nature
ISBN: 107162699X
Category : Science
Languages : en
Pages : 277
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Book Description
This detailed volume provides a comprehensive overview of state-of-the-art metabolomics methods based on mass spectrometry (MS), and their application in food, nutrition, and biomedical research. The chapters assembled herein cover hot topics related to sample preparation, chromatographic and electrophoretic separation, MS-based analysis, as well as data processing and analysis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mass Spectrometry for Metabolomics serves as a timely guide for chemists, biochemists, biologists, nutritionists, clinicians, and other experts working in the growing and exciting field of metabolomics.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309224187
Category : Science
Languages : en
Pages : 354
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Book Description
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
