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Author: Sotirios G. Zarogiannis
Publisher: Frontiers Media SA
ISBN: 2889455416
Category :
Languages : en
Pages : 81
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Book Description
The mesothelium is composed by a single layer of mesothelial cells that vest the serosal cavities (pleural, peritoneal and pericardial) and internal organs of the body. The mesothelial cells have a mixed phenotype of epithelial cells and fibroblasts rendering them remarkable plasticity. Besides providing a slippery surface for the frictionless movement of internal organs, the mesothelium participates in a wide range of physiological and pathophysiological processes. Some of its functions include lung development, trans-cellular and para-cellular transport of ions and water, secretion of glycoproteins (mainly hyaluronan), secretion of cytokines and growth factors, wound healing, response to inflammatory stimuli and induction of inflammation, mesothelial to mesenchymal transition and formation of tunneling nanotubes. Many of these functions are pivotal to physiological conditions such as respiratory development, maintenance of steady volume of serosal fluids and serosal permeability, cell-to-cell communication, re-mesotheliazation of serosal membranes after mechanical (e.g. by asbestos or nanoparticles) or inflammatory injury and participation in immune responses. Deviation from the physiological threshold of these functions results in the development of serosal effusions, induction of serosal and lung fibrosis, induction of mesothelial tumorigenesis, leading thus to devastating pathologies. Treatment of pathologies like mesothelioma, pleural and peritoneal fibrosis (in cases of patients under Peritoneal Dialysis) or lung fibrosis still pose a great challenge for researchers.
Author: Sotirios G. Zarogiannis
Publisher: Frontiers Media SA
ISBN: 2889455416
Category :
Languages : en
Pages : 81
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Book Description
The mesothelium is composed by a single layer of mesothelial cells that vest the serosal cavities (pleural, peritoneal and pericardial) and internal organs of the body. The mesothelial cells have a mixed phenotype of epithelial cells and fibroblasts rendering them remarkable plasticity. Besides providing a slippery surface for the frictionless movement of internal organs, the mesothelium participates in a wide range of physiological and pathophysiological processes. Some of its functions include lung development, trans-cellular and para-cellular transport of ions and water, secretion of glycoproteins (mainly hyaluronan), secretion of cytokines and growth factors, wound healing, response to inflammatory stimuli and induction of inflammation, mesothelial to mesenchymal transition and formation of tunneling nanotubes. Many of these functions are pivotal to physiological conditions such as respiratory development, maintenance of steady volume of serosal fluids and serosal permeability, cell-to-cell communication, re-mesotheliazation of serosal membranes after mechanical (e.g. by asbestos or nanoparticles) or inflammatory injury and participation in immune responses. Deviation from the physiological threshold of these functions results in the development of serosal effusions, induction of serosal and lung fibrosis, induction of mesothelial tumorigenesis, leading thus to devastating pathologies. Treatment of pathologies like mesothelioma, pleural and peritoneal fibrosis (in cases of patients under Peritoneal Dialysis) or lung fibrosis still pose a great challenge for researchers.
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Category :
Languages : en
Pages : 0
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Book Description
The mesothelium is composed by a single layer of mesothelial cells that vest the serosal cavities (pleural, peritoneal and pericardial) and internal organs of the body. The mesothelial cells have a mixed phenotype of epithelial cells and fibroblasts rendering them remarkable plasticity. Besides providing a slippery surface for the frictionless movement of internal organs, the mesothelium participates in a wide range of physiological and pathophysiological processes. Some of its functions include lung development, trans-cellular and para-cellular transport of ions and water, secretion of glycoproteins (mainly hyaluronan), secretion of cytokines and growth factors, wound healing, response to inflammatory stimuli and induction of inflammation, mesothelial to mesenchymal transition and formation of tunneling nanotubes. Many of these functions are pivotal to physiological conditions such as respiratory development, maintenance of steady volume of serosal fluids and serosal permeability, cell-to-cell communication, re-mesotheliazation of serosal membranes after mechanical (e.g. by asbestos or nanoparticles) or inflammatory injury and participation in immune responses. Deviation from the physiological threshold of these functions results in the development of serosal effusions, induction of serosal and lung fibrosis, induction of mesothelial tumorigenesis, leading thus to devastating pathologies. Treatment of pathologies like mesothelioma, pleural and peritoneal fibrosis (in cases of patients under Peritoneal Dialysis) or lung fibrosis still pose a great challenge for researchers.
Author: John S.P. Jones
Publisher: Springer Science & Business Media
ISBN: 1447114043
Category : Medical
Languages : en
Pages : 442
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Book Description
Many books have been written about the pathology of the major organs of the body such as the lungs, heart, gastrointestinal tract etc. Included in these are descriptions - often with a minor emphasis - of pathological conditions which affect their serosal surfaces. In this book I have endeavoured to reverse the process and treat the mesothelium as an organ in its own right, rather than being the "no man's land" between various major structures. A number of pathological conditions are common to the coverings of the three major body cavities - the pleura, pericardium and peritoneum - while some abnormalities are exclusive to one or other sites. I hope that the contents of this book cover a broad enough spectrum of mesothelial diseases to be of help to service pathologists, who are ever increasingly being asked to make diagnoses, particularly on small biopsies of pleural and peritoneal tissues. It is also my hope that the various aspects of the subject have been dealt with in sufficient depth to be of use to pathol ogists engaged in teaching and research, and to those whose interests lie in the structure and function of the mesothelium. There is still much to be learned in understanding the way the mesothelium behaves in the realm of both inflammatory response and tumour formation. If this book provides a stimulus to furthering research in these fields I feel it will have achieved its objective.
Author: Krassimira N. Michailova
Publisher: Springer Science & Business Media
ISBN: 3540280456
Category : Medical
Languages : en
Pages : 151
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Book Description
in the human visceral pleura is the sole reliable criterion for the statement that it belongs to the ‘thick type’, while all observed animals have a ‘thin’ type VP. The mesothelium and underlying structures of the SM represent a highly permeable bidirectional membrane with signi?cant differences in the organ and region tra- port as a local phenomenon after horseradish peroxidase application. Stomata are constant features seen by SEM, but are occasional ?ndings observed by TEM over both sides of the diaphragm, lower intercostal spaces, anterior abdominal wall and greater omentum in untreated animals. Our data extend the location of stomata over the liver and broad ligament of the uterus. We strictly de?ned and nominated the main structures of the lymphatic regions as lymphatic units, stomata, and LL. Several different types of vascularization of omental and extraomental (medias- nal pleura and lesser pelvis) MS are observed after India ink application. Human and animal differences in their location, mesothelial covering, the vessel (blood and lymphatic) supply, free and connective tissue cells and their arrangement are discussed. The mesothelium and the BL changes start early in the gestation and continue throughout the postnatal period. Both cell types (?at and cubic) are already evident through prenatal life.
Author: Thomas Kiefer
Publisher: Springer
ISBN: 3319323393
Category : Medical
Languages : en
Pages : 207
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Book Description
This book covers all aspects of successfully treating patients using chest drains, beginning with anatomy and ending with physiotherapy and pain management. The aim of the book is to provide medical professionals with a step-by-step guide to using a chest drain, with specific chapters on indications, kinds of chest drains, catheters, drainage systems, how to insert a chest tube, complications during placement and handling of a chest drain, removing a chest drain, management of the pleural space and post-procedural care. Unlike general thoracic surgery textbooks, this book gives a complete overview of chest drains in clinical practice to ensure the best possible care of patients.
Author: Philippe Astoul
Publisher: Springer Science & Business Media
ISBN: 3642383513
Category : Medical
Languages : en
Pages : 261
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Book Description
There is an increasing need for medical thoracoscopy performed by pulmonologists, which may be video assisted and has the advantage of being very cost-effective. This book is a comprehensive and up-to-date guide to thoracoscopy for pulmonologists that documents the considerable progress in endoscopic telescopes and instrumentation. Clear practical guidance is provided on technique, and diagnostic, therapeutic, and interventional applications of thoracoscopy are all carefully examined with the aid of high-quality illustrations. Although medical thoracoscopy is much less invasive than thoracotomy, complications can occur in a small number of cases; these are discussed and advice on prevention is provided. The concluding section examines the future of the field, covering developments such as ‘mini’ thoracoscopy, autofluorescence thoracoscopy, and flexi-rigid thoracoscopy.
Author: Ramesh Khanna
Publisher: Springer Science & Business Media
ISBN: 0387789405
Category : Medical
Languages : en
Pages : 927
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Book Description
Nolph and Gokal's Text Book of Peritoneal Dialysis, Third Edition, covers advances made in the field for the past 30 years. During the past two decades, the time during which this therapy has been increasingly utilized, this text has continued to be recognized as the major source of the discipline's base knowledge. The evolution of this text to its newest edition parallels the growth of peritoneal dialysis from Continuous Ambulatory Peritoneal Dialysis in the eighties to the current therapy that encompasses manual and automated therapies with full emphasis on adequacy of dialysis dose. Peritoneal dialysis represents an intracorporeal technique for blood purification. This unique dialysis system represents one of many human attempts to manipulate nature for sustenance of life. The past few years of advances have focused on further improvement of the technique. Areas that have fueled the interest of researchers include: (1) Physiology of high transporters (and the role of genetics and inflammation); (2) Continued debate over the most appropriate adequacy indices (small solute clearances, large solute clearances, clinical assessment etc.); (3) Understanding, preventing and treating the MIA syndrome in PD patients ( including the roles of leptin, and adiponectin); (4) Pathogenesis and newer management strategies of vascular calcification; (5) Continued improvements in infectious complications including peritonitis; (6) Further improvements in catheter technology; (7) Automated techniques; (8) Explaining and correcting PD underutilization; (9) Rationale and applications of newer dialysis solutions; (10) New understanding and approaches to management of osteodystrophy; (11) Refinements in anemia management including new insights in iron metabolism in PD patients; (12) Further definition of indications for PD; (13) The ideal time to initiate dialysis. Newer insight into host defense mechanisms have also made the past decade of advances in the field more meaningful for clinicians. This text also covers the knowledge gained from animal models of peritoneal dialysis. Nolph and Gokal's Textbook of Peritoneal Dialysis, Third Edition is a compilation of the latest knowledge in the field. It cites and describes in great detail, the new discoveries and the evolution of understanding the subject of these discoveries.
Author: Aliya Husain, MD
Publisher: Elsevier Health Sciences
ISBN: 1437723802
Category : Medical
Languages : en
Pages : 632
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Book Description
Save time identifying and diagnosing diseases of the lung, mediastinum and heart with Thoracic Pathology, a volume in the Highy Yield Pathology series. Edited by noted pathologist Dr. Aliya Husain, this medical reference book is designed to help you review the key pathologic features of a full range of thoracic diseases, recognize the classic look of typical specimens, and quickly confirm your diagnoses for more than 400 discreet entities found in the lung, mediastinum, and heart. Find information quickly and easily with a templated, easy-to-reference format. Confirm your diagnoses with excellent color photographs that demonstrate the classic appearance of each disease. Find the answers you need fast with concise bulleted text. Depend on authoritative information from leading experts in the field. Access the full text online, perform quick searches, and download images at www.expertconsult.com. Your first reference for fast, reliable thoracic pathology diagnostic information
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ISBN:
Category :
Languages : en
Pages : 0
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Book Description
The biological outcome of Hyaluronan (also hyaluronic acid, abbreviated HA) interaction with its CD44 or RHAMM receptors recently attracted much attention within the scientific community owing to a Nature article by Tian X et al. (Nature 2013; 499:346-9). The article described a life span exceeding 30 years in naked mole rats, whereas the maximal lifespan of mice, to which the naked mole rat is related, is only 4 years. This observation is accompanied by the finding that the naked mole rat, in contrast to the mouse, does not develop spontaneous tumors during this exceptional longevity. The article provides evidence that interaction of long tissue HA (6000-12,000 kDa) of the naked mole rat with cell surface CD44, in contrast to the interaction of short tissue HA (less than 3000 kDa) with the mouse CD44, makes the difference. More specifically, this communication shows that the interaction of short HA with fibroblasts' CD44 imposes on them susceptibility for malignant transformation, whereas the corresponding interaction with long HA imposes on the fibroblasts a resistance to malignant transformation. The article does not explain the mechanism that underlines these findings. However, the articles, that will be published in the proposed Research Topic in the Inflammation section of Frontiers in Immunology, can bridge not only this gap, but also may explain why interaction between short HA and cell surface CD44 (or RHAMM, an additional HA receptor) enhances the development of inflammatory and malignant diseases. Furthermore, the articles included in the proposed Frontiers Research Topic will show that cancer cells and inflammatory cells share several properties related to the interaction between short HA and cell surface CD44 and/or RHAMM. These shared properties include: 1. Support of cell migration, which allows tumor metastasis and accumulation of inflammatory cells at the inflammation site; 2. Delivery of intracellular signaling, which leads to cell survival of either cancer cells or inflammatory cells; 3. Delivery of intracellular signaling, which activates cell replication and population expansion of either cancer cells or inflammatory cells; and 4. Binding of growth factors to cell surface CD44 of cancer cells or inflammatory cells (i.e., the growth factors) and their presentation to cells with cognate receptors (endothelial cells, fibroblasts), leading to pro-malignant or pro-inflammatory activities. Going back to the naked mole rat story, we may conclude from the proposed articles of this Frontiers Research Topic that the long HA, which displays anti-malignant effect, interferes with the above described pro-malignant potential of the short HA (perhaps by competing on the same CD44 receptor). Extrapolating this concept to Inflammation, the same mechanism (competition?) may be valid for inflammatory (and autoimmune) activities. If this is the case, long HA may be used for therapy of both malignant and inflammatory diseases. Moreover, targeting the interaction between short HA and CD44 (e.g. by anti-CD44 blocking antibodies) may display also a therapeutic effect on both malignant and inflammatory diseases, an issue that encourages not only fruitful exchange of views, but also practical experimental collaboration.
Author: Neil A. Shepherd
Publisher: John Wiley & Sons
ISBN: 1118399684
Category : Medical
Languages : en
Pages : 1
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Book Description
Morson and Dawson’s Gastrointestinal Pathology 5th Edition Edited by Neil A. Shepherd, DM, FRCPath, Gloucestershire Cellular Pathology Laboratory, Cheltenham, UK; Bryan F. Warren, MB, ChB, FRCP (London), FRCPath, John Radcliffe Hospital, Oxford, UK; Geraint T. Williams, OBE, BSc, MD, MRCR, FRCP (London), FRCPath, FMedSci, Cardiff University, Cardiff, UK; Joel K. Greenson, MD, University of Michigan Medical School, Ann Arbor, MI, USA; Gregory Y. Lauwers, MD, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; and Marco R. Novelli, MB, ChB, PhD, FRCPath, University College Hospital, London, UK Emphasizing the important role the gastrointestinal pathologist now plays in patient management, Morson and Dawson’s Gastrointestinal Pathology, 5th Edition, is a comprehensive resource for both training and practice. This revision of a “gold standard” textbook reflects current practice, where the abundance of surgical specimens and the revolution in endoscopy has made virtually the entire gastrointestinal tract accessible to biopsy. Generations of practitioners valued Morson and Dawson’s candid guidance, highly readable text, and abundant, high-quality illustrations. This edition preserves those popular features and, to add an international dimension, now includes authors from North America, the European continent, Asia, and Australia. Authors write on their areas of expertise, with chapters organized into seven major parts: Oesophagus Stomach Small Intestine Appendix Large Intestine The Anal Region Peritoneum Each part opens with a chapter on normal anatomy, dissection, and relevant histology. The following chapters describe the morphology, pathogenesis, and aetiology of specific disorders and incorporate developments in molecular pathology and immunohistochemistry. A concluding chapter in each part summarizes miscellaneous conditions of that organ. More than 700 colour images throughout the text illustrate the discussion. An associated website contains all the figures for easy downloading into presentations. With outstanding contributions from the world’s leading gastrointestinal pathologists and a wealth of new information, Morson and Dawson’s Gastrointestinal Pathology, 5th Edition, will serve a new generation of gastrointestinal pathologists, gastroenterologists, and pathologists as the definitive reference for the field.
