Molecular Biology of the Cell PDF Download
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Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category : Cells
Languages : en
Pages : 0
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Book Description
Author:
Publisher:
ISBN: 9780815340720
Category :
Languages : en
Pages :
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Book Description
Author: William Stillwell
Publisher: Newnes
ISBN: 0080931286
Category : Science
Languages : en
Pages : 379
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Book Description
An Introduction to Biological Membranes: From Bilayers to Rafts covers many aspects of membrane structure/function that bridges membrane biophysics and cell biology. Offering cohesive, foundational information, this publication is valuable for advanced undergraduate students, graduate students and membranologists who seek a broad overview of membrane science. - Brings together different facets of membrane research in a universally understandable manner - Emphasis on the historical development of the field - Topics include membrane sugars, membrane models, membrane isolation methods, and membrane transport
Author: Neale Ridgway
Publisher: Elsevier
ISBN: 0444634495
Category : Science
Languages : en
Pages : 625
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Book Description
Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. - Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry - References from current literature will be included in each chapter to facilitate more in-depth study - Key concepts are supported by figures and models to improve reader understanding - Chapters provide historical perspective and current analysis of each topic
Author: Jacques Fantini
Publisher: Academic Press
ISBN: 0128004924
Category : Medical
Languages : en
Pages : 398
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Book Description
Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer's, Creutzfeldt-Jakob's and Parkinson's. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders. - Written to provide a "hands-on" approach for readers - Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings - Step-by-step guide to memorize and draw lipid structures - Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique
Author: E. Anibal Disalvo
Publisher: Springer
ISBN: 3319190601
Category : Science
Languages : en
Pages : 295
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Book Description
This book is about the importance of water in determining the structure, stability and responsive behavior of biological membranes. Water confers to lipid membranes unique features in terms of surface and mechanical properties. The analysis of the hydration forces, plasticiser effects, controlled hydration, formation of microdomains of confined water suggests that water is an active constituent in a water-lipid system. The chapters describe water organization at the lipid membrane–water interphase, the water penetration, the long range water structure in the presence of lipid membranes by means of X-ray and neutron scattering, general polarization, fluorescent probes, ATR-FTIR and near infrared spectroscopies, piezo electric methods, computer simulation and surface thermodynamics. Permeation, percolation, osmotic stress, polarization, protrusion, sorption, hydrophobicity, density fluctuations are treated in detail in self-assembled bilayers. Studies in lipid monolayers show the correlation of surface pressure with water activity and its role in peptide and enzyme interactions. The book concludes with a discussion on anhydrobiosis and the effect of water replacement in microdomains and its consequence for cell function. New definitions of lipid/water interphases consider water not only as a structural-making solvent but as a mediator in signalling metabolic activity, modulating protein insertion and enzymatic activity, triggering oscillatory reactions and functioning of membrane bound receptors. Since these effects occur at the molecular level, membrane hydration appears fundamental to understand the behavior of nano systems and confined environments mimicking biological systems. These insights in structural, thermodynamical and mechanical water properties give a base for new paradigms in membrane structure and function for those interested in biophysics, physical chemistry, biology, bio and nano medicine, biochemistry, biotechnology and nano sciences searching for biotechnological inputs in human health, food industry, plant growing and energy conversion.
Author: Philip L. Yeagle
Publisher: CRC Press
ISBN: 1439809585
Category : Medical
Languages : en
Pages : 398
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Book Description
Biological membranes provide the fundamental structure of cells and viruses. Because much of what happens in a cell or in a virus occurs on, in, or across biological membranes, the study of membranes has rapidly permeated the fields of biology, pharmaceutical chemistry, and materials science. The Structure of Biological Membranes, Third Edition pro
Author:
Publisher:
ISBN: 9780444803030
Category :
Languages : en
Pages : 596
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Book Description
Author: John Robert Silvius
Publisher:
ISBN:
Category : Cell membranes
Languages : en
Pages : 0
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Book Description
The aims of this work were twofold: first, to generate a biologi cal membrane system in which the lipid fatty acyl composition can be var ied essentially at will, and to study the relationship of lipid proper ties to membrane function in such a system, and secondly, to synthesize and characterize some novel phospholipids which provide valuable model systems whose behavior is relevant to that of the lipids in the biologi cal membrane studied. Toward the former objective, I have developed a simple method for converting the simple cell wall-less prokaryote Acholeplasma laidlawii B into a total fatty acid auxotroph, using avidin to completely inhibit de novo fatty acid synthesis and chain elongation kn vivo . Cells thus treated can grow well when any of a wide variety of fatty acids are add ed to the culture medium, and if a single fatty acid is added, the cells incorporate it into their membrane lipids to the extent of 95+% of the total lipid acyl chains if the fatty acid can support cell growth. The cellular growth-supporting ability of a fatty acid appears to rest on its physical and not its metabolic properties. 'Fatty acid-homogeneous' membranes or membrane lipids, obtained from cells grown with avidin plus any of a number of single fatty acids which are good growth substrates, exhibit a markedly sharper lipid phase transition by differential ther mal analysis than do normal membranes or membrane lipids, which have a heterogeneous fatty acyl composition. The protein and lipid head-group composition of fatty acid-homogeneous membranes varies somewhat depend ing on the nature of the lipid acyl chains, but a variety of experiments indicate that such variations are unlikely to produce changes of a qualitative nature in the physical behavior of the membrane lipids. The potential for manipulation of lipid fatty acyl chains and physical pro perties in the A. laidlawii B membrane has been used to study the physi cal basis of the membrane lipid effects on the temperature dependence of a membrane enzyme activity, the (Na + ,Mg 2 +)-ATPase, which appears to func tion as an osmoregulatory cation pump jui vivo . My results, analyzed in the light of an extensive theoretical analysis of Arrhenius plot behavi or, suggest that the ATPase's catalytic activity is not altered by changes in the lipids around it so long as they are in the liquid-crys talline state, but that a membrane lipid phase transition occurring on cooling the membrane can cause the boundary lipids of the ATPase to en ter a 'gel-like' state and thereby to inactivate the enzyme. Working toward the second objective noted above, that of develop ing and characterizing good pure-lipid model systems for the fatty acid- homogeneous A. laidlawii B membrane, I synthesized a number of branched- chain, odd-chain saturated, monounsaturated and cyclopropane fatty acids and their phosphatidylcholine (PC) derivatives. I then characterized the thermotropic behavior of the fully hydrated PC's by differential thermal analysis. By studying the effect of acyl chain length and struc ture on the thermotropic behavior of hydrated diacyl PC's, I have been able to draw various conclusions regarding the nature of the acyl chain packing in the gel state and regarding the function of various types of methyl-branched and alicyclic lipid acyl chains in membranes. Finally, I have shown that the gel-to-liquid-crystalline phase transition tem peratures of pure PC's and of A. laidlawii B membrane lipids of like fat ty acyl composition correlate very well, indicating that the lipid acyl chain interactions in the two systems are fundamentally similar and that the former lipid system is in fact a good model for the biological membrane.
