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Author: Feng C Zhou
Publisher: Academic Press
ISBN: 0128193999
Category : Medical
Languages : en
Pages : 0
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Book Description
Site Specific and Global Epigenomic Editing: Principles and Applications, Volume 33 highlights the expanding role that epigenetics plays in pathogenesis, the full range of sites for possible epigenetic modification, and the potential to target these sites to modulate disease progression. The book answers key questions, including which of the hundreds of epigenomic marks and features are relevant, and which are likely to serve a role in regulating gene expression, cell behavior and phenotypic outcomes. This volume is the first to provide a thorough, conceptual introduction to epigenetic regulation and a thorough accounting of sites for possible epigenetic edits and disease modulation. Included protocols and applied case studies examine early disease targets and likely pathways of therapeutic significance while also outlining common challenges in the field. The book addresses its topic in a comprehensive, but accessible manner, highlighting practical tools and burning questions remaining in the field to enable fresh research. - Offers a full, conceptual and applied framework for implementing epigenomic editing in biological research and drug discovery - Discusses fundamental theory, experimental design and applied approaches alongside common research challenges and bioethical concerns - Examines epigenomic editing's potential role in the modulation of developmental, neuropsychiatric and immunological disorders, as well as in viral infections and cancer
Author: Feng C Zhou
Publisher: Academic Press
ISBN: 0128193999
Category : Medical
Languages : en
Pages : 0
Get Book Here
Book Description
Site Specific and Global Epigenomic Editing: Principles and Applications, Volume 33 highlights the expanding role that epigenetics plays in pathogenesis, the full range of sites for possible epigenetic modification, and the potential to target these sites to modulate disease progression. The book answers key questions, including which of the hundreds of epigenomic marks and features are relevant, and which are likely to serve a role in regulating gene expression, cell behavior and phenotypic outcomes. This volume is the first to provide a thorough, conceptual introduction to epigenetic regulation and a thorough accounting of sites for possible epigenetic edits and disease modulation. Included protocols and applied case studies examine early disease targets and likely pathways of therapeutic significance while also outlining common challenges in the field. The book addresses its topic in a comprehensive, but accessible manner, highlighting practical tools and burning questions remaining in the field to enable fresh research. - Offers a full, conceptual and applied framework for implementing epigenomic editing in biological research and drug discovery - Discusses fundamental theory, experimental design and applied approaches alongside common research challenges and bioethical concerns - Examines epigenomic editing's potential role in the modulation of developmental, neuropsychiatric and immunological disorders, as well as in viral infections and cancer
Author: Stefan Jurga
Publisher: Springer Nature
ISBN: 3030147924
Category : Medical
Languages : en
Pages : 624
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Book Description
This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.
Author: Sandeep Kumar Verma
Publisher: Elsevier
ISBN: 0323898815
Category : Science
Languages : en
Pages : 706
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Book Description
CAC series highlights new advances in the field. This Volume 94 presents interesting chapters on the recent advances in the role of nanoparticles in plant biotechnology. Each chapter is written by international experts in the respective fields. Provides the authority and expertise of leading contributors from an international board of authors. Presents the latest release in the Comprehensive Analytical Chemistry series Updated release includes the latest information on Biosynthesized nanomaterials
Author: Thomas J. Kelly
Publisher: Cold Spring Harbor Laboratory Press
ISBN:
Category : Science
Languages : en
Pages : 520
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Book Description
Understanding the mechanism and regulation of eukaryotic DNA replication remains a fundamental area of modern biological research. Replication of the cell s genome is one of the critical, regulated events that occur during cell proliferation and cell cycle progression. This volume presents important advances in this field that were discussed at the Cold Spring Harbor Cancer Cells meeting on Eukaryotic DNA Replication. The papers cover topics as diverse as viral DNA replication, genome amplification, cell cycle and developmental control of DNA replication, replication proteins, and the replication and function of centromeres and telomeres. This volume is a valuable resource for researchers and students.
Author: Noel R. Rose
Publisher: Wiley-Blackwell
ISBN: 9781573318884
Category : Medical
Languages : en
Pages : 0
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Book Description
This volume of The Year in Immunology series features reviews of topics in human immunology, including B1 B cells, BCL-2 family members, Wiskott-Aldrich syndrome, reverse vaccinology, anti-b2-glycoprotein I, the role of autoimmunity In thromboangiitis obliterans (Buerger's Disease), long pentraxin PTX3 as a paradigm for humoral pattern recognition molecules, and control of inflammatory heart disease by CD4+ T cells.
