Author: Jon M. Oatley
Publisher: Springer
ISBN: 1493975056
Category : Science
Languages : en
Pages : 385
Book Description
This book provides a resource of current understandings about various aspects of the biology of spermatogonia in mammals. Considering that covering the entire gamut of all things spermatogonia is a difficult task, specific topics were selected to provide foundational information that will be useful for seasoned researchers in the field of germ cell biology as well as investigators entering the area. Looking to the future, the editors predict that the foundational information provided in this book -- combined with the advent of new tools and budding interests in use of non-rodent mammalian models -- will produce another major advance in knowledge regarding the biology of spermatogonia over the next decade. In particular, we anticipate that the core molecular machinery driving different spermatogonial states in most, if not all, mammals will be described fully, the extrinsic signals emanating from somatic support cell populations to influence spermatogonial functions will become fully known, and the capacity to derive long-term cultures of SSCs and transplant the population to regenerate spermatogenesis and fertility will become a reality for higher order mammals.
The Biology of Mammalian Spermatogonia
Biology of Spermatogenesis and Spermatozoa in Mammals
Author: Sardul S. Guraya
Publisher: Springer Science & Business Media
ISBN: 3642716385
Category : Science
Languages : en
Pages : 441
Book Description
Publisher: Springer Science & Business Media
ISBN: 3642716385
Category : Science
Languages : en
Pages : 441
Book Description
Molecular Biology of The Cell
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
Book Description
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
Book Description
ANALYSIS OF TRANSGENIC MOUSE MODELS TO STUDY MAMMALIAN SPERMATOGONIA.
Author: Oleksandr Kirsanov
Publisher:
ISBN:
Category :
Languages : en
Pages : 92
Book Description
Spermatogenesis in the mammalian testis results in the daily production of millions of spermatozoa. This developmental process is founded upon the actions of a small population of spermatogonial stem cells (SSCs). As SSCs divide, their progeny must either remain an SSC to maintain the stem cell pool (self-renewal) or become an undifferentiated progenitor spermatogonium that proliferates prior to differentiating in response to retinoic acid (RA) and entering meiosis. Our laboratory is focused on understanding the mechanisms that regulate these fate decisions as well as defining the changes that occur downstream of RA that prepare spermatogonia for entry into meiosis. Currently, researchers have been unable to readily isolate pure populations of spermatogonia in the developing or adult testis. To address this, I have examined multiple transgenic mouse models to identify those with germ cell-specific expression of fluorescent reporter genes that will enable us to isolate spermatogonia using fluorescence-activated cell sorting (FACS). The results in this thesis describe these efforts, and document the identification of an excellent mouse model for future studies in our laboratory to understand the mechanisms underlying spermatogonial development. This work was supported by a grant from the NIH/NICHD (HD090083) to C.B.G.
Publisher:
ISBN:
Category :
Languages : en
Pages : 92
Book Description
Spermatogenesis in the mammalian testis results in the daily production of millions of spermatozoa. This developmental process is founded upon the actions of a small population of spermatogonial stem cells (SSCs). As SSCs divide, their progeny must either remain an SSC to maintain the stem cell pool (self-renewal) or become an undifferentiated progenitor spermatogonium that proliferates prior to differentiating in response to retinoic acid (RA) and entering meiosis. Our laboratory is focused on understanding the mechanisms that regulate these fate decisions as well as defining the changes that occur downstream of RA that prepare spermatogonia for entry into meiosis. Currently, researchers have been unable to readily isolate pure populations of spermatogonia in the developing or adult testis. To address this, I have examined multiple transgenic mouse models to identify those with germ cell-specific expression of fluorescent reporter genes that will enable us to isolate spermatogonia using fluorescence-activated cell sorting (FACS). The results in this thesis describe these efforts, and document the identification of an excellent mouse model for future studies in our laboratory to understand the mechanisms underlying spermatogonial development. This work was supported by a grant from the NIH/NICHD (HD090083) to C.B.G.
Spermiogenesis
Author: David Phillips
Publisher: Elsevier
ISBN: 0323161197
Category : Science
Languages : en
Pages : 73
Book Description
Spermiogenesis summarizes the process of sperm structure and development in a variety of organisms. It attempts to illustrate the structure of the organelles that characterize mature spermatozoa and to trace the morphogenesis of these organelles during sperm formation. This task is complicated by considerable variations in the structure of spermatozoa among different species and the lack of good morphological studies of sperm structure and spermiogenesis in many animal groups. The general morphological features of mammalian sperm structure differ in some ways from the features of insect sperm, the spermatozoa produced by insects appearing relatively more simple. When the functions and developmental regions of the organelles are considered, homologies between complex structures found in mammalian sperm and simpler insect sperm structures may be deduced even though the organelles in question are quite dissimilar in appearance. Such homologies will be stressed in an effort to present as general a picture of spermiogenesis as seems consistent with the species-specific variations that exist. This book will be a useful, stimulating reference for students of reproductive biology.
Publisher: Elsevier
ISBN: 0323161197
Category : Science
Languages : en
Pages : 73
Book Description
Spermiogenesis summarizes the process of sperm structure and development in a variety of organisms. It attempts to illustrate the structure of the organelles that characterize mature spermatozoa and to trace the morphogenesis of these organelles during sperm formation. This task is complicated by considerable variations in the structure of spermatozoa among different species and the lack of good morphological studies of sperm structure and spermiogenesis in many animal groups. The general morphological features of mammalian sperm structure differ in some ways from the features of insect sperm, the spermatozoa produced by insects appearing relatively more simple. When the functions and developmental regions of the organelles are considered, homologies between complex structures found in mammalian sperm and simpler insect sperm structures may be deduced even though the organelles in question are quite dissimilar in appearance. Such homologies will be stressed in an effort to present as general a picture of spermiogenesis as seems consistent with the species-specific variations that exist. This book will be a useful, stimulating reference for students of reproductive biology.
Test No. 483: Mammalian Spermatogonial Chromosomal Aberration Test
Author: OECD
Publisher: OECD Publishing
ISBN: 9264243178
Category :
Languages : en
Pages : 13
Book Description
This test measures structural chromosomal aberrations (both chromosome- and chromatid-type) in dividing spermatogonial germ cells and is, therefore, expected to be predictive of induction of heritable mutations in these germ cells
Publisher: OECD Publishing
ISBN: 9264243178
Category :
Languages : en
Pages : 13
Book Description
This test measures structural chromosomal aberrations (both chromosome- and chromatid-type) in dividing spermatogonial germ cells and is, therefore, expected to be predictive of induction of heritable mutations in these germ cells
Introduction to Mammalian Reproduction
Author: Daulat Tulsiani
Publisher: Springer Science & Business Media
ISBN: 146150273X
Category : Science
Languages : en
Pages : 405
Book Description
Introduction to Mammalian Reproduction is a welcome contribution to the fields of gametogenesis, gamete transport, fertilization, and reproduction technologies. Key topics covered include: *formation and maturation of male gametes; *morphology and physiology of female gametes; *how the sperm meets the egg; *sperm-egg fusion, egg activation, and implantation of fertilized egg; *assisted reproduction and environmental chemicals that have an effect on formation and function of male and female gametes. This book is for both researchers and students involved in reproductive biology.
Publisher: Springer Science & Business Media
ISBN: 146150273X
Category : Science
Languages : en
Pages : 405
Book Description
Introduction to Mammalian Reproduction is a welcome contribution to the fields of gametogenesis, gamete transport, fertilization, and reproduction technologies. Key topics covered include: *formation and maturation of male gametes; *morphology and physiology of female gametes; *how the sperm meets the egg; *sperm-egg fusion, egg activation, and implantation of fertilized egg; *assisted reproduction and environmental chemicals that have an effect on formation and function of male and female gametes. This book is for both researchers and students involved in reproductive biology.
The Male Germ Cell
Author: Bernard Robaire
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 536
Book Description
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 536
Book Description
Mammalian Spermatogenesis
Author: John Edward Shorec Moore
Publisher:
ISBN:
Category :
Languages : en
Pages : 10
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 10
Book Description
The Functional Anatomy of the Spermatozoon
Author: Björn A. Afzelius
Publisher: Elsevier
ISBN: 1483187322
Category : Science
Languages : en
Pages : 406
Book Description
The Functional Anatomy of the Spermatozoon is the 23rd volume of the series Wenner-Gren Center International Symposium Series, documenting the proceedings of the Second International Symposium on Comparative Spermatology, held in August 1973. This volume mainly focuses on the understanding of the early events at fertilization and the preliminaries of this biological process. This text specifically tackles the sperm at fertilization of lower animals and mammals, sperm motility and diversity, and spermatogenesis. This book concludes with discussions on capacitation and maturation of mammalian spermatozoa. This compendium will be valuable to morphologists, physiologists, immunologists, and biochemists, as well as to academicians interested in the study of functional anatomy of the spermatozoon.
Publisher: Elsevier
ISBN: 1483187322
Category : Science
Languages : en
Pages : 406
Book Description
The Functional Anatomy of the Spermatozoon is the 23rd volume of the series Wenner-Gren Center International Symposium Series, documenting the proceedings of the Second International Symposium on Comparative Spermatology, held in August 1973. This volume mainly focuses on the understanding of the early events at fertilization and the preliminaries of this biological process. This text specifically tackles the sperm at fertilization of lower animals and mammals, sperm motility and diversity, and spermatogenesis. This book concludes with discussions on capacitation and maturation of mammalian spermatozoa. This compendium will be valuable to morphologists, physiologists, immunologists, and biochemists, as well as to academicians interested in the study of functional anatomy of the spermatozoon.