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Author: Tony Sweeney
Publisher: Melbourne University
ISBN: 9780522850338
Category : Malaria
Languages : en
Pages : 0
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Book Description
During World War II malaria was one of the most powerful enemies of the Australian troops in the South West Pacific. In 1943 the Australian Army formed a special research team to tackle the problem. This book documents the Australian search for a cure, and the scientific breakthroughs.
Author: Tony Sweeney
Publisher: Melbourne University
ISBN: 9780522850338
Category : Malaria
Languages : en
Pages : 0
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Book Description
During World War II malaria was one of the most powerful enemies of the Australian troops in the South West Pacific. In 1943 the Australian Army formed a special research team to tackle the problem. This book documents the Australian search for a cure, and the scientific breakthroughs.
Author: Karen M. Masterson
Publisher: Penguin
ISBN: 0698140133
Category : History
Languages : en
Pages : 494
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Book Description
A fascinating and shocking historical exposé, The Malaria Project is the story of America's secret mission to combat malaria during World War II—a campaign modeled after a German project which tested experimental drugs on men gone mad from syphilis. American war planners, foreseeing the tactical need for a malaria drug, recreated the German model, then grew it tenfold. Quickly becoming the biggest and most important medical initiative of the war, the project tasked dozens of the country’s top research scientists and university labs to find a treatment to remedy half a million U.S. troops incapacitated by malaria. Spearheading the new U.S. effort was Dr. Lowell T. Coggeshall, the son of a poor Indiana farmer whose persistent drive and curiosity led him to become one of the most innovative thinkers in solving the malaria problem. He recruited private corporations, such as today's Squibb and Eli Lilly, and the nation’s best chemists out of Harvard and Johns Hopkins to make novel compounds that skilled technicians tested on birds. Giants in the field of clinical research, including the future NIH director James Shannon, then tested the drugs on mental health patients and convicted criminals—including infamous murderer Nathan Leopold. By 1943, a dozen strains of malaria brought home in the veins of sick soldiers were injected into these human guinea pigs for drug studies. After hundreds of trials and many deaths, they found their “magic bullet,” but not in a U.S. laboratory. America 's best weapon against malaria, still used today, was captured in battle from the Nazis. Called chloroquine, it went on to save more lives than any other drug in history. Karen M. Masterson, a journalist turned malaria researcher, uncovers the complete story behind this dark tale of science, medicine and war. Illuminating, riveting and surprising, The Malaria Project captures the ethical perils of seeking treatments for disease while ignoring the human condition.
Author: Henry M. Staines
Publisher: Springer Science & Business Media
ISBN: 3034604793
Category : Medical
Languages : en
Pages : 318
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Book Description
Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309165938
Category : Medical
Languages : en
Pages : 384
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Book Description
For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 9780309045278
Category : Medical
Languages : en
Pages : 312
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Book Description
Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241564997
Category : Medical
Languages : en
Pages : 35
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Book Description
The World Health Organization's Global Technical Strategy for Malaria 2016- 2030 has been developed with the aim to help countries to reduce the human suffering caused by the world's deadliest mosquito-borne disease. Adopted by the World Health Assembly in May 2015 it provides comprehensive technical guidance to countries and development partners for the next 15 years emphasizing the importance of scaling up malaria responses and moving towards elimination. It also highlights the urgent need to increase investments across all interventions - including preventive measures diagnostic testing treatment and disease surveillance- as well as in harnessing innovation and expanding research. By adopting this strategy WHO Member States have endorsed the bold vision of a world free of malaria and set the ambitious new target of reducing the global malaria burden by 90% by 2030. They also agreed to strengthen health systems address emerging multi-drug and insecticide resistance and intensify national cross-border and regional efforts to scale up malaria responses to protect everyone at risk.
Author: Geoffrey Grant Quail
Publisher: Simon and Schuster
ISBN: 1925520234
Category : History
Languages : en
Pages : 385
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Book Description
Historically, prolonged campaigns have been frequently lost or won because of the greater fitness of one of the combatant armies. In the twentieth century, infection was still a major problem, leading to withdrawal from Gallipoli, and the near defeat of the Allies due to malaria early in the Second World War’s Pacific campaign. Malaria emerged again as a major problem in the Vietnam War. The Australian Army Medical Corps, founded in 1901, learned from past medical experience. However, errors leading to significant morbidity did occur mainly in relation to malaria. These errors included lack of instruction of doctors sent to New Guinea with the Australian Force in the Great War, inadequate prophylactic measures against malaria in New Guinea early in World War Two, failure to perceive the threat of emerging resistant strains of malaria in the 1960s, and military commanders not fully implementing the recommendations of their medical advisers. Many Australian campaigns have taken place in tropical locations; a substantial amount of scientific work to prevent and manage tropical diseases has therefore been conducted by the Army Medical Corps’ medical researchers—particularly in the Land Headquarters Medical Research Unit and the Army Malaria Institute. Their work extends well beyond the military, greatly improving health outcomes throughout the world. This book recognises the efforts of both.
Author: Alec Glen
Publisher: Birlinn
ISBN: 0857906127
Category : Biography & Autobiography
Languages : en
Pages : 372
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Book Description
This memoir by a Scottish doctor who was born and went on to work in Govan was found among family papers long after his death in 1972. Less an account of the author's inner life, it is a graphic narrative, by a practitioner in the hospitals and homes of a major city, of hands-on medical care during much of the twentieth century. After training as a medical student on the wards of Glasgow hospitals, at the outbreak of the First World War the young doctor joined the army and served as a medical officer for the duration. Early on he provides a shattering account of the hopeless slaughter at Gallipoli,where he survived almost certain death many times as his companions fell around him. Only 100 men survived of his battalion of 1,000. His later service in the Middle East and Mesopotamia is an astonishing tale of courage and endurance, interwoven with spells of leave, during which the Scot encountered exotic experiences undreamed of in Govan. After the war Glen became a GP in Govan, one of the poorest areas in Britain, at a time long before the National Health Service. Preventable illnesses were often a death sentence for old and young alike. The extremes of poverty and suffering he witnessed brought home to him that he was in the front line once more, but in a different kind of warfare. The Second World War brought new challenges, and a post-war transformation when the NHS was finally came into being. Glen's shrewd commentary on the birth-pangs of the new institution provides valuable insights for the ongoing debate about this most controversial of public services.
Author: Kevin N. Couper
Publisher: Frontiers Media SA
ISBN: 2889630463
Category :
Languages : en
Pages : 487
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Book Description
Malaria, caused by infection with protozoan parasites belonging to the genus Plasmodium, is a highly prevalent and lethal infectious disease, responsible for 435,000 deaths in 2017. Optimism that malaria was gradually being controlled and eliminated has been tempered by recent evidence that malaria control measures are beginning to stall and that Plasmodium parasites are developing resistance to front-line anti-malarial drugs. An important milestone has been the recent development of a malaria vaccine (Mosquirix) for use in humans, the very first against a parasitic infection. Unfortunately, this vaccine has modest and short-lived efficacy, with vaccinated individuals possibly being at increased risk of severe malarial disease when protection wanes. Thus, to define new ways to combat malaria, there remains an urgent requirement to identify the immune mechanisms that promote resistance to malarial disease and to understand why these so often fail. The review and primary research articles in this Research Topic illustrate the breadth of research performed worldwide aimed to understand the biology of the Plasmodium parasite, the roles of the various cell types that act within the immune response against the parasite, and the parasitological and immunological basis of severe malarial disease. The articles in section 1 exemplify the different vaccination strategies being developed and tested by the research community in the fight against malaria. The articles in section 2 review important overarching aspects of malaria immunology and the use of models to study human malaria. The articles in section 3 describe the ways through which the Plasmodium parasite is initially recognised by the immune system during infection, how the parasite can directly impact this critical event to restrict anti-Plasmodial immunity, and resolve the roles of key innate cell populations, such as dendritic cells, in coordinating malarial immunity. The articles in sections 4-6 outline the roles T and B cell populations play during malaria, highlighting the activation, diversification and regulation of the crucial cell types during malaria, and discuss some of the reasons adaptive immunity to malaria is often considered so poor compared with other diseases. The articles in section 7 provide up to date information on the pathogenesis of cerebral malaria, bridging our understanding of the syndrome in humans with information learned from animal models. Overall, the articles in this research, many of which are published by leaders in the malaria field, emphasize the imagination and technical advances being employed by researchers against malaria. We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Author: Chris Pratt
Publisher: Balboa Press
ISBN: 1982293713
Category : Biography & Autobiography
Languages : en
Pages : 435
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Book Description
Dave, Ray, Morris and Alex Rohrlach were Australian Lutherans of German descent who served in the Australian Army and Navy in the Pacific during World War Two. In a fascinating biography of the brothers, Chris Pratt chronicles the events of their lives before, during, and in the aftermath of war. Dave, a Lutheran missionary in New Guinea, captained his mission schooner to rescue defeated Australian soldiers from New Britain in the opening months of the war. Ray served in a motorised infantry unit before enduring a year in an isolated malarial outpost in Dutch New Guinea. Morris struggled through two amphibious landings in Japanese occupied Borneo. Alex survived kamikaze attacks and a battle with a Japanese fleet in the Philippines to witness from an Australian heavy cruiser the signing of the Japanese surrender in Tokyo Bay. Included are historical maps and photographs provided by the family.
