Practical Medicinal Chemistry with Macrocycles PDF Download
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Author: Eric Marsault
Publisher: John Wiley & Sons
ISBN: 1119092566
Category : Science
Languages : en
Pages : 617
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Book Description
Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations
Author: Eric Marsault
Publisher: John Wiley & Sons
ISBN: 1119092566
Category : Science
Languages : en
Pages : 617
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Book Description
Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations
Author: Jeremy I Levin
Publisher: Royal Society of Chemistry
ISBN: 1849737010
Category : Medical
Languages : en
Pages : 526
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Book Description
This series provides a comprehensive resource for postgraduate students and for scientists in academia or industry wanting to learn topics outside their own areas of expertise.
Author: Matthew B. Coppock
Publisher: Humana
ISBN: 9781071616888
Category : Technology & Engineering
Languages : en
Pages : 469
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Book Description
This volume explores the latest techniques and strategies used to study the field of peptide macrocycles. The chapters in this book ae organized into four parts: macrocycles synthesis, combinational library synthesis and screening, macrocycle characterization, and unique applications. Part One looks at a variety of peptide cyclization methodologies, and Part Two describes methods for the creation of peptide macrocycles libraries and their subsequent screening against biological targets of interest. Part Three discusses the study and characterization of peptide macrocycle-target interactions, and Part Four introduces unique applications for peptide macrocycles, from higher-order structure formation to post-synthetic functional modifications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Peptide Macrocycles: Methods and Protocols is a valuable resource for both novice and expert researchers looking to learn more about this developing field.
Author: Frank Davis
Publisher: John Wiley & Sons
ISBN: 1119990297
Category : Technology & Engineering
Languages : en
Pages : 1069
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Book Description
Macrocyclic molecules contain rings made up of seven or more atoms. They are interesting because they provide building blocks for synthesizing precise two or three dimensional structures – an important goal in nanotechnology. For example, they can be used to develop nanosized reaction vessels, cages, switches and shuttles, and have potential as components in molecular computers. They also have applications as catalysts and sensors. Macrocycles: Construction, Chemistry and Nanotechnology Applications is an essential introduction this important class of molecules and describes how to synthesise them, their chemistry, how they can be used as nanotechnology building blocks, and their applications. A wide range of structures synthesised over the past few decades are covered, from the simpler cyclophanes and multi-ring aromatic structures to vases, bowls, cages and more complex multi-ring systems and 3D architectures such as “pumpkins”, interlocking chains and knots. Topics covered include: principles of macrocycle synthesis simple ring compounds multi-ring aromatic structures porphyrins and phthalocanines cyclophanes crown ethers, cryptands and spherands calixarenes, resorcinarenes, cavitands, carcerands, and heterocalixarenes cyclodextrins cucurbiturils cyclotriveratylenes rotaxanes catenanes complex 3D architectures, including trefoils and knots Macrocycles: Construction, Chemistry and Nanotechnology Applications distills the essence of this important topic for undergraduate and postgraduate students, and for researchers in other fields interested in getting a general insight into this increasingly important class of molecules.
Author: Kimoon Kim
Publisher: Royal Society of Chemistry
ISBN: 1788015002
Category : Science
Languages : en
Pages : 572
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Book Description
This book provides a complete overview of cucurbituril chemistry, covering fundamental aspects including history, synthesis and host-guest chemistry.
Author: N. V. Gerbeleu
Publisher: John Wiley & Sons
ISBN: 3527613811
Category : Science
Languages : de
Pages : 574
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Book Description
The synthesis of macrocycles is an art in itself. Template-controlled synthesis provides elegant access to fascinating macrocyclic structures. Polyazamacrocycles, crown ethers, cryptands, rotaxanes, knots -- the range of macrocyclic compounds is as broad as their potential application as molecular switches, in ion exchange, electron transfer or catalysis. This book provides authoritative information on all aspects of template-controlled macrocyclizations. It covers in depth the current state of research on template processes - novel synthetic techniques and mechanistic approaches. The critical discussion of the diverse synthetic routes includes the detailed characterization of the broad variety of macrocyclic products. References to applications of macrocyclic compounds and over 1,500 citations make this handbook an indispensable tool for chemists in academia and industry. Researchers in organic and supramolecular chemistry, biotechnology, and inorganic chemistry will find inspiration for the design, synthesis, and myriad uses of new synthetic macrocycles.
Author: J.H. Zagal
Publisher: Springer Science & Business Media
ISBN: 0387284303
Category : Science
Languages : en
Pages : 828
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Book Description
In response to significant developments in sensor science and technology, this book offers insight into the various extended applications and developments of N4 macrocycle complexes in biomimetic electrocatalysis. Chapters are devoted to the chemistry, electronic and electrochemical properties of porphyrin- based polymetallated supramolecular redox catalysts and their applications in analytical and photoelectrochemical molecular devices; the use of porphyrins, phthalocyanines and related complexes as electrocatalysts for the detection of a wide variety of environmentally polluting and biologically relevant molecules; and the use of electropolymerized metalloporphyrin and metallophthalocyanine films as powerful materials for analytical tools, especially for sensing biologically relevant species.
Author: F. Vögtle
Publisher: Springer Science & Business Media
ISBN: 3642701086
Category : Science
Languages : en
Pages : 421
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Book Description
The scientific and practical interest in coronands (crown ethers), cryptands, podands as complexing agents for cations as well as for anions and neutral low molecular species is undeniable 1,2). The chemistry of crown compounds is steadily increasing. About 250 original papers dealing with crown chemistry appeared only in 1980. New molecules· with crown ether properties are constantly synthesized and new applications discov,?red. Owing to lack of space, only a small number of the original publications is men tioned here. Thus, in the literature compilation only some, but relevant works are selected for each chapter. Whenever possible, reference is made to reviews or review-like articles alone by means of which origin,al works can be consulted. The reviews given under ref. 1) are considered to be the most relevant. The formulae presented in the figures should be understood as representative structures outlining a specific field. 2 Classification of Oligo-/Multidentate Neutral Ligands and of their Complexes Today, a distinction is made between the classical ring oligoethers (crown ethers) and monocyclic coronands, oligocyclic spherical cryptands and the acyclic podands with respect to topological aspects 3). This classification and the topology are illustrated in Fig. 1, each figure representing the minimum number of donor atoms and chain segments characteristic of each class of compounds. Multidentate mono cyclic ligands with any type of donor atoms are called coronands ("crown compounds"), while the term crown ether should be reserved for cyclic oligoethers exclusively containing oxygen as donor atom.
Author: Anne Pankhurst
Publisher: Coachwise 1st4sport
ISBN: 9781905540433
Category : Coaching (Athletics)
Languages : en
Pages : 188
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Book Description
Author: K. Gloe
Publisher: Springer Science & Business Media
ISBN: 1402036876
Category : Science
Languages : en
Pages : 450
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Book Description
Macrocyclic Chemistry: Current Trends and Future Perspectives illustrates essential concepts in this expanding research field covering both basic and applied studies. Written by well-known experts from around the world, the topics of the chapters range from new macrocyclic architectures with different functions and self-assembly processes through to the modeling and dynamics of such systems. The content also reflects on application possibilities in analytical chemistry, separation processes, material preparation and medicine. Thus this book serves as a creative source of research strategies and methodic tools. Providing an excellent overview of the field, this book will be a valuable resource for researchers in industry and academic institutions as well as for teachers of science and graduate students. This book is devoted to the long-standing tradition of the International Symposia on Macrocyclic Chemistry (ISMC) and published to coincide with the 30th meeting, Dresden, Germany.
