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Author: Nagapatnam Subbaraman, Lakshman
Publisher: University of Waterloo
ISBN:
Category :
Languages : en
Pages :
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Book Description
Over 60 proteins have been detected in the tear film and among these lysozyme has attracted the greatest attention. Several techniques for elucidating the identity, quantity and conformation of lysozyme deposited on soft contact lenses have been developed. Lysozyme also deposits on the newly introduced silicone hydrogel (SH) lens materials, but in extremely low levels compared to conventional hydrogel lenses. Hence, a major analytical complication with the study of the SH contact lens materials relates to the minute quantity of deposited lysozyme. The first project of this thesis involved the development of a method whereby lysozyme mass extracted from SH lens materials would be preserved over time and would be compatible with an optimized Western blotting procedure. This methodological development was incorporated into a clinical study (CLENS-100® and Silicone Hydrogels - CLASH study) wherein the difference in the degree of total protein, the difference in lysozyme deposition and activity recovered from lotrafilcon A SH lens material when subjects used surfactant containing rewetting drops (CLENS-100®) versus control saline was investigated. The remaining experiments were in vitro experiments wherein the lenses were doped in artificial lysozyme solution containing l℗¿I-labeled lysozyme. These experiments were performed to gain insight into the kinetics of lysozyme deposition on SH lens materials and also the efficacy of a reagent in extracting lysozyme from SH lens materials. A protocol was developed whereby the percentage loss of lysozyme mass found on lotrafilcon A SH lenses was reduced from approximately 33% to
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Author: Nagapatnam Subbaraman, Lakshman
Publisher: University of Waterloo
ISBN:
Category :
Languages : en
Pages :
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Book Description
Over 60 proteins have been detected in the tear film and among these lysozyme has attracted the greatest attention. Several techniques for elucidating the identity, quantity and conformation of lysozyme deposited on soft contact lenses have been developed. Lysozyme also deposits on the newly introduced silicone hydrogel (SH) lens materials, but in extremely low levels compared to conventional hydrogel lenses. Hence, a major analytical complication with the study of the SH contact lens materials relates to the minute quantity of deposited lysozyme. The first project of this thesis involved the development of a method whereby lysozyme mass extracted from SH lens materials would be preserved over time and would be compatible with an optimized Western blotting procedure. This methodological development was incorporated into a clinical study (CLENS-100® and Silicone Hydrogels - CLASH study) wherein the difference in the degree of total protein, the difference in lysozyme deposition and activity recovered from lotrafilcon A SH lens material when subjects used surfactant containing rewetting drops (CLENS-100®) versus control saline was investigated. The remaining experiments were in vitro experiments wherein the lenses were doped in artificial lysozyme solution containing l℗¿I-labeled lysozyme. These experiments were performed to gain insight into the kinetics of lysozyme deposition on SH lens materials and also the efficacy of a reagent in extracting lysozyme from SH lens materials. A protocol was developed whereby the percentage loss of lysozyme mass found on lotrafilcon A SH lenses was reduced from approximately 33% to
Author: Feng Zhang
Publisher:
ISBN:
Category :
Languages : en
Pages : 168
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Book Description
Author: Holly Irene Lorentz
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Nathan Efron
Publisher: Elsevier Health Sciences
ISBN: 0702066613
Category : Medical
Languages : en
Pages : 512
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Book Description
In this thoroughly revised and updated third edition of Contact Lens Practice, award-winning author, researcher and lecturer, Professor Nathan Efron, provides a comprehensive, evidence-based overview of the scientific foundation and clinical applications of contact lens fitting. The text has been refreshed by the inclusion of ten new authors – a mixture of scientists and clinicians, all of whom are at the cutting edge of their specialty. The chapters are highly illustrated in full colour and subject matter is presented in a clear and logical format to allow the reader to quickly hone in the desired information. Ideal for an optometrist, ophthalmologist, orthoptist, optician, student, or work in the industry, this book will serve as an essential companion and guide to current thinking and practice in the contact lens field. Highlights of this edition include a new chapter on myopia control contact lenses, as well are completely rewritten chapters, by new authors, on keratoconus, orthokeratology, soft and rigid lens measurement and history taking.
Author: Vijay Kumar Thakur
Publisher: John Wiley & Sons
ISBN: 1119224454
Category : Technology & Engineering
Languages : en
Pages : 738
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Book Description
This unique multidisciplinary 8-volume set focuses on the emerging issues concerning synthesis, characterization, design, manufacturing and various other aspects of composite materials from renewable materials and provides a shared platform for both researcher and industry. The Handbook of Composites from Renewable Materials comprises a set of 8 individual volumes that brings an interdisciplinary perspective to accomplish a more detailed understanding of the interplay between the synthesis, structure, characterization, processing, applications and performance of these advanced materials. The Handbook comprises 169 chapters from world renowned experts covering a multitude of natural polymers/ reinforcement/ fillers and biodegradable materials. Volume 7 is solely focused on the "Nanocomposites: Science and Fundamentals" of renewable materials. Some of the important topics include but not limited to: Preparation, characterization, and applications of nanomaterials from renewable resources; hydrogels and its nanocomposites from renewable resources: preparation of chitin-based nanocomposite materials through gelation with ionic liquid; starch-based bionanocomposites; biorenewable nanofiber and nanocrystal; investigation of wear characteristics of dental composite reinforced with rice husk-derived nanosilica filler particles; performance of regenerated cellulose/vermiculite nanocomposites fabricated via ionic liquid; preparation, structure, properties, and interactions of the PVA/cellulose composites; green composites with cellulose nanoreinforcements; biomass composites from bamboo-based micro/nanofibers; synthesis and medicinal properties of polycarbonates and resins from renewable sources; nanostructured polymer composites with modified carbon nanotubes; organic–inorganic nanocomposites derived from polysaccharides; natural polymer-based nanocomposites; cellulose whisker-based green polymer composites; poly (lactic acid) nanocomposites reinforced with different additives; nanocrystalline cellulose; halloysite-based bionanocomposites; nanostructurated composites based on biodegradable polymers and silver nanoparticles; starch-based biomaterials and nanocomposites; green nanocomposites based on PLA and natural organic fillers; and chitin and chitosan-based nanocomposites.
Author: Alan Ng
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Purpose To study the impact of lactoferrin and lipids on the kinetic deposition and denaturation of lysozyme on contact lens materials.
Author: Edward S. Bennett
Publisher: Lippincott Williams & Wilkins
ISBN: 1469832895
Category : Medical
Languages : en
Pages : 872
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Book Description
Designed to be used as a quick reference, this fourth edition of the Clinical Manual of Contact Lenses allows readers to easily find the topic and information they need without having to search through an entire chapter to find it. Rigid gas permeable lens design and fitting, soft lens problem-solving, astigmatic management, and bifocal correction are just a few of the subjects covered in this manual. Each chapter includes sample cases to reinforce and demonstrate the practical nature of the topic, with nomograms and proficiency checklists summarizing and emphasizing the important points. With this guide, students and practitioners will have a dependable resource to help fit, evaluate, and troubleshoot any contact lenses, especially specialty designs for years to come.
Author: Zeman
Publisher: Routledge
ISBN: 1351431501
Category : Medical
Languages : en
Pages : 654
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Book Description
Integrates knowledge on microfiltration and ultrification, membrane chemistry, and characterization methods with the engineering and economic aspects of device performance, device and module design, processes, and applications. The text provides a discussion of membrane fundamentals and an analytical framework for designing and developing new filtrations systems for a broad range of technologically important functions. It offers information on membrane liquid precursors, fractal and stochastic pore space analysis, novel and advanced module designs, and original process design calculations.
Author: Huan-Cheng Chang
Publisher: John Wiley & Sons
ISBN: 1119477085
Category : Science
Languages : en
Pages : 294
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Book Description
The most comprehensive reference on fluorescent nanodiamond physical and chemical properties and contemporary applications Fluorescent nanodiamonds (FNDs) have drawn a great deal of attention over the past several years, and their applications and development potential are proving to be manifold and vast. The first and only book of its kind, Fluorescent Nanodiamonds is a comprehensive guide to the basic science and technical information needed to fully understand the fundamentals of FNDs and their potential applications across an array of domains. In demonstrating the importance of FNDs in biological applications, the authors bring together all relevant chemistry, physics, materials science and biology. Nanodiamonds are produced by powerful cataclysmic events such as explosions, volcanic eruptions and meteorite impacts. They also can be created in the lab by high-pressure high-temperature treatment of graphite or detonating an explosive in a reactor vessel. A single imperfection can give a nanodiamond a specific, isolated color center which allows it to function as a single, trapped atom. Much smaller than the thickness of a human hair, a nanodiamond can have a huge surface area that allows it to bond with a variety of other materials. Because of their non-toxicity, nanodiamonds may be useful in biomedical applications, such as drug delivery and gene therapy. The most comprehensive reference on a topic of rapidly increasing interest among academic and industrial researchers across an array of fields Includes numerous case studies and practical examples from many areas of research and industrial applications, as well as fascinating and instructive historical perspectives Each chapter addresses, in-depth, a single integral topic including the fundamental properties, synthesis, mechanisms and functionalisation of FNDs The first book published by the key patent holder with his research group in the field of FNDs Fluorescent Nanodiamonds is an important working resource for a broad range of scientists and engineers in industry and academia. It will also be a welcome reference for instructors in chemistry, physics, materials science, biology and related fields.
Author: Terry T. Schaeffer
Publisher: Getty Publications
ISBN: 0892366451
Category : Art
Languages : en
Pages : 221
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Book Description
The impact of light on works of art and archival materials has long been an issue of concern to conservators and other museum professionals, yet the literature on this subject has never been systematically reviewed. This volume fills that gap by providing a survey of the impact of exposure to light with an emphasis on photoflash and reprographic sources. The information provided will assist the professional audience, especially conservators and collections managers, in assessing the risk to art and archival objects of such exposures. The text surveys relevant photophysical and photochemical principles, photometric and radiometric measurement, and the spectral outputs of several light sources. Materials discussed include colorants and natural fibers; pulp, paper, and wood; natural and synthetic polymers; fluorescent whitening agents; photographic and reprographic materials; and objects containing combinations of materials. Approximations and assumptions used in the evaluation process are discussed in some detail, with examples of the different types of calculations. The Research in Conservation reference series presents the findings of research conducted by the Getty Conservation Institute and its individual and institutional research partners, as well as state-of-the-art reviews of conservation literature. Each volume covers a topic of current interest to conservators and conservation scientists.
