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Author: Joseph J. Mangano
Publisher: CRC Press
ISBN: 1351082655
Category : Science
Languages : en
Pages : 240
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Book Description
Atomic weapons and nuclear power plants: they promised to ensure world peace and provide efficient energy to Americans during the 1940s and 1950s. Meanwhile, the post war prosperity led to the most dramatic population explosion ever witnessed in the United States: the "baby boomer" generation.Times and politics may change, but many baby boomers-as well as their descendants-now live with an unforeseen result of the nuclear age. Rates of immune-related diseases have risen steadily throughout the past few decades, from allergies to cancer. While advances in medical care have kept death rates relatively low, the increased prevalence of certain diseases cannot be ignored.Low Level Radiation and Immune System Damage: An Atomic Era Legacy establishes an undeniable connection between the nuclear build up of the past and the widespread health problems seen today. While baby boomers were growing up in the 40s and 50s, above-ground atomic bomb tests and start ups of civilian nuclear power plants were carried out without fear of public exposure to radioactive emissions.Although the consequences of low-level radiation are still hotly debated, Mangano's research findings emphasize a direct link between nuclear exposure and immune system deficiency. In addition to substantial data on immune disease trends among Americans born between the mid-1940s and mid-1960s, Mangano also examines similar issues concerning baby boomer children and grandchildren. Health professionals, environmentalists, historians and students alike will find much to learn from these pages.As America and the world come to terms with the post-Cold War era, there are still many lessons to recognize, consider, and learn from the still-recent past. Low Level Radiation and Immune System Damage: An Atomic Era Legacy explores a relentless trend that will not soon be over-with potential repercussions into the 21st century.
Author: Joseph J. Mangano
Publisher: CRC Press
ISBN: 1351082655
Category : Science
Languages : en
Pages : 240
Get Book Here
Book Description
Atomic weapons and nuclear power plants: they promised to ensure world peace and provide efficient energy to Americans during the 1940s and 1950s. Meanwhile, the post war prosperity led to the most dramatic population explosion ever witnessed in the United States: the "baby boomer" generation.Times and politics may change, but many baby boomers-as well as their descendants-now live with an unforeseen result of the nuclear age. Rates of immune-related diseases have risen steadily throughout the past few decades, from allergies to cancer. While advances in medical care have kept death rates relatively low, the increased prevalence of certain diseases cannot be ignored.Low Level Radiation and Immune System Damage: An Atomic Era Legacy establishes an undeniable connection between the nuclear build up of the past and the widespread health problems seen today. While baby boomers were growing up in the 40s and 50s, above-ground atomic bomb tests and start ups of civilian nuclear power plants were carried out without fear of public exposure to radioactive emissions.Although the consequences of low-level radiation are still hotly debated, Mangano's research findings emphasize a direct link between nuclear exposure and immune system deficiency. In addition to substantial data on immune disease trends among Americans born between the mid-1940s and mid-1960s, Mangano also examines similar issues concerning baby boomer children and grandchildren. Health professionals, environmentalists, historians and students alike will find much to learn from these pages.As America and the world come to terms with the post-Cold War era, there are still many lessons to recognize, consider, and learn from the still-recent past. Low Level Radiation and Immune System Damage: An Atomic Era Legacy explores a relentless trend that will not soon be over-with potential repercussions into the 21st century.
Author: Katalin Lumniczky
Publisher: Frontiers Media SA
ISBN: 2889454746
Category :
Languages : en
Pages : 283
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Book Description
For long, high dose ionizing radiation was considered as a net immune suppressing agent, as shown, among others, by the exquisite radiosensitivity of the lymphoid system to radiation-induced cell killing. However, recent advances in radiobiology and immunology have made this picture more complex. For example, the recognition that radiation-induced bystander effects, share common mediators with various immunological signalling processes, suggests that they are at least partly immune mediated. Another milestone was the finding, in the field of onco-immunology, that local tumor irradiation can modulate the immunogenicity of tumor cells and the anti-tumor immune responsiveness both locally, in the tumor microenvironment, and at systemic level. These observations paved the way for studies exploring optimal combinations of radiotherapy and immunotherapy in order to achieve a synergistic effect to eradicate tumors. However, not all interactions between radiation and the immune system are beneficial, as it was recognized that many of radiation-induced late side effects are also of immune and inflammatory nature. Currently perhaps the most studied field of research in radiation biology is focused around the biological effects of low doses, where many of the observed pathophysiological endpoints are due to mechanisms other than direct radiation-induced cell killing and are immune-related. Finally, it must not be forgotten that the interactions between the ionizing radiations and the immune system are bi-directional, and activation of the immune system also influences the outcome of radiation exposure. This Research Topic brings together 23 articles and aims to give an overview of the complex and very often contradictory nature of the interactions between ionizing radiation and the immune system. Due to its increasing penetrance in the population both through medical diagnostic or environmental sources or during cosmic travel low dose ionizing radiation exposure is becoming a major epidemiological concern world-wide. Several of the articles within the Research Topic specifically address potential long-term health consequences and the underlying mechanisms of low dose radiation exposure. A major intention of the Editors was also to draw the attention of the non-radiobiological scientific community on the fact that ionizing radiation is by far more than purely an immune suppressing agent.
Author: Robert C. Bast, Jr.
Publisher: John Wiley & Sons
ISBN: 111900084X
Category : Medical
Languages : en
Pages : 2004
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Book Description
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author: Sōhei Kondō
Publisher:
ISBN: 9784906434015
Category : Ionizing radiation
Languages : en
Pages : 0
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Book Description
Author: Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation
Publisher: National Academies Press
ISBN: 0309133343
Category : Science
Languages : en
Pages : 422
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Book Description
This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309255716
Category : Medical
Languages : en
Pages : 424
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Book Description
In the late 1980s, the National Cancer Institute initiated an investigation of cancer risks in populations near 52 commercial nuclear power plants and 10 Department of Energy nuclear facilities (including research and nuclear weapons production facilities and one reprocessing plant) in the United States. The results of the NCI investigation were used a primary resource for communicating with the public about the cancer risks near the nuclear facilities. However, this study is now over 20 years old. The U.S. Nuclear Regulatory Commission requested that the National Academy of Sciences provide an updated assessment of cancer risks in populations near USNRC-licensed nuclear facilities that utilize or process uranium for the production of electricity. Analysis of Cancer Risks in Populations near Nuclear Facilities: Phase 1 focuses on identifying scientifically sound approaches for carrying out an assessment of cancer risks associated with living near a nuclear facility, judgments about the strengths and weaknesses of various statistical power, ability to assess potential confounding factors, possible biases, and required effort. The results from this Phase 1 study will be used to inform the design of cancer risk assessment, which will be carried out in Phase 2. This report is beneficial for the general public, communities near nuclear facilities, stakeholders, healthcare providers, policy makers, state and local officials, community leaders, and the media.
Author:
Publisher: Academic Press
ISBN: 012803419X
Category : Medical
Languages : en
Pages : 301
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Book Description
Regulatory T Cells in Health and Disease focuses on the mechanism by which T cells become regulatory T cells, the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer. - Contains contributions from leading authorities in the field of regulatory T cell biology - Informs and updates on all the latest developments in the field - Explores the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309058953
Category : Science
Languages : en
Pages : 78
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Book Description
Author: Simon S. Lo
Publisher: Springer Science & Business Media
ISBN: 364225604X
Category : Medical
Languages : en
Pages : 433
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Book Description
Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.
Author: Colin J. Martin
Publisher: Oxford University Press, USA
ISBN: 0199655219
Category : Medical
Languages : en
Pages : 551
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Book Description
Written by practitioners experienced in the field, 'Practical Radiation Protection in Healthcare' provides a practical guide for medical physicists and others involved with radiation protection in the healthcare environment.
