Author: Jeffrey Noebels
Publisher: Oxford University Press
ISBN: 0199842590
Category : Medical
Languages : en
Pages : 1258
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Book Description
H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.
Author: Jenn Bennett
Publisher: Simon and Schuster
ISBN: 1451620543
Category : Fiction
Languages : en
Pages : 388
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Book Description
Meet Arcadia Bell: bartender, renegade magician, fugitive from the law. . . . Being the spawn of two infamous occultists (and alleged murderers) isn’t easy, but freewheeling magician Arcadia “Cady” Bell knows how to make the best of a crummy situation. After hiding out for seven years, she’s carved an incognito niche for herself slinging drinks at the demon-friendly Tambuku Tiki Lounge. But she receives an ultimatum when unexpected surveillance footage of her notorious parents surfaces: either prove their innocence or surrender herself. Unfortunately, the only witness to the crimes was an elusive Æthyric demon, and Cady has no idea how to find it. She teams up with Lon Butler, an enigmatic demonologist with a special talent for sexual spells and an arcane library of priceless stolen grimoires. Their research soon escalates into a storm of conflict involving missing police evidence, the decadent Hellfire Club, a ruthless bounty hunter, and a powerful occult society that operates way outside the law. If Cady can’t clear her family name soon, she’ll be forced to sacrifice her own life . . . and no amount of running will save her this time.
Author: Kinfolk Kinfolk
Publisher: Kinfolk
ISBN: 9781736264102
Category : Family & Relationships
Languages : en
Pages : 120
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Book Description
A new magazine for people with children, from the team behind Kinfolk. Kindling is a place to explore the new ideas and fresh perspectives that come with being a parent. It’s non-judgmental, unfussy and made to be enjoyed by anyone currently raising a child under the age of ten. We’re interested in exploring the big ideas around parenthood, not what your child should be having for dinner or wearing at the weekend. Compact and colorful, the magazine is designed to be kept and treasured—whether on a coffee table or a child’s bookshelf. Inside The Emotions Issue, you’ll find an interview with the professor of psychology who advised on Pixar’s Inside Out, a workbook geared towards helping your child talk about their feelings, and a photo essay in which fruits and vegetables bring common idioms to life. Just ask yourself: What would it really look like to be “cool as a cucumber”? Kindling is also packed with features and columns that answer questions including: What’s it like to spend four years traveling with your parents? What can the Gruffalo teach us about fatherhood? And how should you answer a child if they blindside you with a tough question like “Why do people die?”? Designed to be read by adults but shared with children, Kindling is brought to life through the playful drawings of Norwegian illustrator Espen Friberg, and contains an activity section packed with suggestions for fun, free and (occasionally) educational games that parents and children can enjoy together.
Author: Iowa
Publisher:
ISBN:
Category : Iowa
Languages : en
Pages : 1134
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Book Description
Contains the reports of state departments and officials for the preceding fiscal biennium.
Author: Michael E. Corcoran
Publisher: Springer Science & Business Media
ISBN: 146155375X
Category : Medical
Languages : en
Pages : 507
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Book Description
The last Kindling Conference was organized by Dr. Juhn Wada and held at the Univer sity of British Columbia, Vancouver, B. C. , in 1989. In the intervening years, research on kin dling has proceeded at an explosive pace and significant advances have been made in our understanding of the molecular biological, anatomical, and physiological substrates of kin dling, as well as in our appreciation of the age-dependent effects and complex behavioral consequences of kindling, its sensitivity to drugs, and its relevance to the clinical epilepsies. In order to review these developments and to provide researchers with an opportunity to in teract face to face and discuss the issues that preoccupy us all, we organized the Fifth Interna tional Conference on Kindling, in Victoria, B. C. , in the summer of 1996. Most of the stalwarts in kindling research were invited, as were a number of investigators whose research on kindling has become prominent in the past few years. We continue to miss the late Graham Goddard, the discoverer of kindling, and were saddened by the recent death of Eric Lothman, a prolific researcher and clinician who would have been a prominent participant. We were deeply disturbed to learn of the death of Frank Morrell, one of the earliest kindlers and an eminent neurologist, who died several months after our conference.
Author: New York (State). Legislature. Assembly
Publisher:
ISBN:
Category : New York (State)
Languages : en
Pages : 946
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Book Description
Author:
Publisher:
ISBN:
Category : Mines and mineral resources
Languages : en
Pages : 1226
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Book Description
Author: Saint Louis (Mo.)
Publisher:
ISBN:
Category : Saint Louis (Mo.)
Languages : en
Pages : 794
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Book Description
Includes reports of the heads of the various municipal departments.
Author: Thomas LYNN
Publisher:
ISBN:
Category :
Languages : en
Pages : 486
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Book Description
Author: United States. Patent Office
Publisher:
ISBN:
Category :
Languages : en
Pages : 1542
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Book Description
