Author: C Fathman
Publisher: Elsevier
ISBN: 032314537X
Category : Science
Languages : en
Pages : 581
Book Description
Isolation, Characterization, and Utilization of T Lymphocyte Clones is a summary of information regarding T lymphocyte clones, including their usefulness. Organized into nine parts, the book begins with discussions on the soluble factors that can influence the growth of cloned T cells and the utilization of T cell hybridomas for analysis of T cell functions, emphasizing the biochemical and functional properties of helper and suppressor factors. The book then looks into the analysis of T cell clones and hybridomas using techniques of somatic cell genetics. The clonal analysis by limiting dilution, the characteristics of murine T cell clones reactive with alloantigens and soluble antigens, and the human T cell clones are described as well. This volume is valuable to those interested in the field of cloning of immunocompetent T cells.
Isolation Characterization, and Utilization of T Lymphocyte Clones
The Lymphocyte
Author: Marchalonis
Publisher: CRC Press
ISBN: 9780824777975
Category : Science
Languages : en
Pages : 452
Book Description
Publisher: CRC Press
ISBN: 9780824777975
Category : Science
Languages : en
Pages : 452
Book Description
Immunogenetics
Author: Gabriel S Panayi
Publisher: Butterworth-Heinemann
ISBN: 1483164616
Category : Medical
Languages : en
Pages : 417
Book Description
Immunogenetics is a 12-chapter book that begins with the elucidation of the major histocompatibility complex genes and their role in autoimmune and infectious diseases. Subsequent chapters explore the human major histocompatibility complex, including implications of their complement genes for linkage disequilibrium and disease associations. This book also describes the genetics of human immunoglobulins; T-cell clones; genes of the major histocompatibility complex of the mouse; and the generation, characterization, and use of monoclonal antibodies of murine and human origin. Specific diseases are also discussed; these include spondoarthritides, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and autoimmune thyroid disease. This book will be of beneficial value to specialists in infectious diseases, endocrinology, connective tissue diseases, and neurology, as well as to medical scientists in immunology and molecular biology.
Publisher: Butterworth-Heinemann
ISBN: 1483164616
Category : Medical
Languages : en
Pages : 417
Book Description
Immunogenetics is a 12-chapter book that begins with the elucidation of the major histocompatibility complex genes and their role in autoimmune and infectious diseases. Subsequent chapters explore the human major histocompatibility complex, including implications of their complement genes for linkage disequilibrium and disease associations. This book also describes the genetics of human immunoglobulins; T-cell clones; genes of the major histocompatibility complex of the mouse; and the generation, characterization, and use of monoclonal antibodies of murine and human origin. Specific diseases are also discussed; these include spondoarthritides, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and autoimmune thyroid disease. This book will be of beneficial value to specialists in infectious diseases, endocrinology, connective tissue diseases, and neurology, as well as to medical scientists in immunology and molecular biology.
Journal of the National Cancer Institute
Author:
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 770
Book Description
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 770
Book Description
The T-Cell Receptors
Author: Tak W. Mak
Publisher: Springer Science & Business Media
ISBN: 1468454064
Category : Medical
Languages : en
Pages : 243
Book Description
The importance of thymus-dependent cells, or T cells, in the generation of a successful immune response was first realized in the early sixties. In the follow ing two decades, a succession of elegant experiments established the antigen specificity of T cells and their ability to perform both as regulatory and effector cells. T cells were shown to be essential in most immune reactions, playing a crucial role in augmenting the activity of effector T and B cells against 'foreign' antigen, as well as in the suppression of effector activity against self antigens. The means by which T cells differentiate 'foreign' from 'self' antigens is based on their recognition of antigen almost exclusively in the context of self major histocompatibility complex products, unlike B cells, which recognize an tigen alone. It is this recognition, mediated by the T-cell receptor, that sets into motion the diverse cell-cell interactions, which control the differentiation and regulation of the immune response. Although its importance was well established, the molecular nature of the T-cell receptor remained elusive for two decades. Many hypotheses as to its structure and precise function were put forward, using immunoglobulin as a basis for conjecture, but "the Holy Grail of Immunology" remained ephemeral until three years ago. In the ensuing years, both immunologists and molecular biologists have contributed to an explosion of data unsurpassed by any previous period in the field.
Publisher: Springer Science & Business Media
ISBN: 1468454064
Category : Medical
Languages : en
Pages : 243
Book Description
The importance of thymus-dependent cells, or T cells, in the generation of a successful immune response was first realized in the early sixties. In the follow ing two decades, a succession of elegant experiments established the antigen specificity of T cells and their ability to perform both as regulatory and effector cells. T cells were shown to be essential in most immune reactions, playing a crucial role in augmenting the activity of effector T and B cells against 'foreign' antigen, as well as in the suppression of effector activity against self antigens. The means by which T cells differentiate 'foreign' from 'self' antigens is based on their recognition of antigen almost exclusively in the context of self major histocompatibility complex products, unlike B cells, which recognize an tigen alone. It is this recognition, mediated by the T-cell receptor, that sets into motion the diverse cell-cell interactions, which control the differentiation and regulation of the immune response. Although its importance was well established, the molecular nature of the T-cell receptor remained elusive for two decades. Many hypotheses as to its structure and precise function were put forward, using immunoglobulin as a basis for conjecture, but "the Holy Grail of Immunology" remained ephemeral until three years ago. In the ensuing years, both immunologists and molecular biologists have contributed to an explosion of data unsurpassed by any previous period in the field.
Monoclonal Antibodies and Functional Cell Lines
Author: Roger H. Kennett
Publisher: Springer Science & Business Media
ISBN: 1468446738
Category : Medical
Languages : en
Pages : 427
Book Description
This volume serves as a follow-up to our previous book, MonoclonalAntibodies Hybridomas: A New Dimension in Biological Analyses. We continue the theme of monoclonal antibodies and their applications, attempting to cover some of the areas not covered in the previous volume. We again include an appendix de scribing methods useful to those who ar-e beginning to apply these techniques in their own laboratories. This volume will be followed by another concentrating on the combination of monoclonal antibody techniques with molecular genetic techniques to study structure/function relationships at the level of both the gene and gene product. Roger H. Kennett Kathleen B. Bechtol Philadelphia, Pennsylvania Thomas J. McKearn Princeton, New Jersey IX Acknowledgments Roger Kennett acknowledges the patience and support of his wife, Carol, and his family, friends, and colleagues during the work on this volume, and again thanks, above all, the Lord, Jesus Christ. Kathleen Bechtol wishes to thank colleagues and friends for their support and understanding during the months of preparation of this volume. Tom McKearn acknowledges and thanks his wife, Pat, and his family for their support and encouragement. Xl Contents PART I INTRODUCTION 1 Introduction: Reflections on Nine Years of Monoclonal Antibodies from Hybridomas 3 ROGER H. KENNETT, KATHLEEN B. BECHTOL, AND THOMAS J. McKEARN 1. Biotechnology'S "Coming of Age". . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 II. Monoclonal Antibodies-An Overview of Applications. . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 III. Commercialization of Monoclonal Antibody Technology.. . . .. ... . .... .... .. . ... . . 10 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 . . . . . . . . . . . . . . . . . . . . .
Publisher: Springer Science & Business Media
ISBN: 1468446738
Category : Medical
Languages : en
Pages : 427
Book Description
This volume serves as a follow-up to our previous book, MonoclonalAntibodies Hybridomas: A New Dimension in Biological Analyses. We continue the theme of monoclonal antibodies and their applications, attempting to cover some of the areas not covered in the previous volume. We again include an appendix de scribing methods useful to those who ar-e beginning to apply these techniques in their own laboratories. This volume will be followed by another concentrating on the combination of monoclonal antibody techniques with molecular genetic techniques to study structure/function relationships at the level of both the gene and gene product. Roger H. Kennett Kathleen B. Bechtol Philadelphia, Pennsylvania Thomas J. McKearn Princeton, New Jersey IX Acknowledgments Roger Kennett acknowledges the patience and support of his wife, Carol, and his family, friends, and colleagues during the work on this volume, and again thanks, above all, the Lord, Jesus Christ. Kathleen Bechtol wishes to thank colleagues and friends for their support and understanding during the months of preparation of this volume. Tom McKearn acknowledges and thanks his wife, Pat, and his family for their support and encouragement. Xl Contents PART I INTRODUCTION 1 Introduction: Reflections on Nine Years of Monoclonal Antibodies from Hybridomas 3 ROGER H. KENNETT, KATHLEEN B. BECHTOL, AND THOMAS J. McKEARN 1. Biotechnology'S "Coming of Age". . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 II. Monoclonal Antibodies-An Overview of Applications. . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 III. Commercialization of Monoclonal Antibody Technology.. . . .. ... . .... .... .. . ... . . 10 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 . . . . . . . . . . . . . . . . . . . . .
Immunological Aspects of Reproduction in Mammals
Author: D. B. Crighton
Publisher: Butterworth-Heinemann
ISBN: 1483162958
Category : Nature
Languages : en
Pages : 542
Book Description
Immunological Aspects of Reproduction in Mammals contains papers presented during a symposium at the University of Nottingham Easter School. The scholarly presentations provide a wealth of information on the field of reproductive immunology and indicate just how complex this field is and how many questions still remain to be answered. The book begins with reviews of the current status of the complexities and uncertainties of the cellular basis of the immune response and the structure and function of antibodies. This is followed by separate chapters on the assessment and interpretation of the phenomena surrounding autoimmune and isoimmune reactions to spermatozoa; advances in defining the distribution and degree of exposure of major histocompatibility antigens; the reproductive immunology of the mouse, horse, and sheep; and fetal and neonatal immunity. Subsequent chapters present studies of immunization of several species with either the hypothalamic hormone LH-RH, pituitary gonadotrophins, or ovarian steroids; and studies directed towards efforts to enhance animal production by either active or passive immunization of female farm animals against steroid hormones. This book will be a valuable reference text for those already involved in the field and a stimulus for others to enter this complex and fascinating area of research.
Publisher: Butterworth-Heinemann
ISBN: 1483162958
Category : Nature
Languages : en
Pages : 542
Book Description
Immunological Aspects of Reproduction in Mammals contains papers presented during a symposium at the University of Nottingham Easter School. The scholarly presentations provide a wealth of information on the field of reproductive immunology and indicate just how complex this field is and how many questions still remain to be answered. The book begins with reviews of the current status of the complexities and uncertainties of the cellular basis of the immune response and the structure and function of antibodies. This is followed by separate chapters on the assessment and interpretation of the phenomena surrounding autoimmune and isoimmune reactions to spermatozoa; advances in defining the distribution and degree of exposure of major histocompatibility antigens; the reproductive immunology of the mouse, horse, and sheep; and fetal and neonatal immunity. Subsequent chapters present studies of immunization of several species with either the hypothalamic hormone LH-RH, pituitary gonadotrophins, or ovarian steroids; and studies directed towards efforts to enhance animal production by either active or passive immunization of female farm animals against steroid hormones. This book will be a valuable reference text for those already involved in the field and a stimulus for others to enter this complex and fascinating area of research.
Immunity to Cancer
Author: Arnold Reif
Publisher: Elsevier
ISBN: 0323143563
Category : Medical
Languages : en
Pages : 679
Book Description
Immunity to Cancer documents the proceedings of a conference on ""Immunity to Cancer"" held at Williamsburg, Virginia, September 10-12, 1984. This was the first open conference since the New York Academy of Sciences meeting in 1975 that attempted to address the entire range of topics encompassed by tumor immunology and immunotherapy. The papers presented in this volume were invited from experts in diverse areas of tumor immunology and closely related subjects. There was an attempt to proceed logically from a consideration of the antigenicity of tumors and the use of monoclonal antibodies to examine specific antigens, to a review of regulatory and effector mechanisms. Immunological approaches to therapy were then considered systematically, both for classical modes of immunotherapy and for the newly expanded categories of biological response modifiers or biomodulators. Also included were papers on vaccination against cancer and on the analogy between the strategies for chemotherapy and immunotherapy.
Publisher: Elsevier
ISBN: 0323143563
Category : Medical
Languages : en
Pages : 679
Book Description
Immunity to Cancer documents the proceedings of a conference on ""Immunity to Cancer"" held at Williamsburg, Virginia, September 10-12, 1984. This was the first open conference since the New York Academy of Sciences meeting in 1975 that attempted to address the entire range of topics encompassed by tumor immunology and immunotherapy. The papers presented in this volume were invited from experts in diverse areas of tumor immunology and closely related subjects. There was an attempt to proceed logically from a consideration of the antigenicity of tumors and the use of monoclonal antibodies to examine specific antigens, to a review of regulatory and effector mechanisms. Immunological approaches to therapy were then considered systematically, both for classical modes of immunotherapy and for the newly expanded categories of biological response modifiers or biomodulators. Also included were papers on vaccination against cancer and on the analogy between the strategies for chemotherapy and immunotherapy.
Annual Report - National Eye Institute
Author: National Eye Institute
Publisher:
ISBN:
Category : Ophthalmology
Languages : en
Pages : 404
Book Description
Publisher:
ISBN:
Category : Ophthalmology
Languages : en
Pages : 404
Book Description
Human Immunogenetics
Author: S. D. Litwin
Publisher: CRC Press
ISBN: 1000103730
Category : Health & Fitness
Languages : en
Pages : 849
Book Description
Delineating fundamental concepts of contemporary immunogenetics, this reference/text examines specific immunogenetic systems in terms of molecular biochemistry and immunophysiology. Covers material in diverse fields, including infectious diseases, cell biology, virology, molecular genetics. Comprise
Publisher: CRC Press
ISBN: 1000103730
Category : Health & Fitness
Languages : en
Pages : 849
Book Description
Delineating fundamental concepts of contemporary immunogenetics, this reference/text examines specific immunogenetic systems in terms of molecular biochemistry and immunophysiology. Covers material in diverse fields, including infectious diseases, cell biology, virology, molecular genetics. Comprise