Involvement of the Immediate Early Genes NGFI-A and Arc in Enriched Environment-induced Plasticity in the Central Nervous System [microform] PDF Download
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Author: Raphael Pinaud
Publisher: National Library of Canada = Bibliothèque nationale du Canada
ISBN: 9780612665842
Category :
Languages : en
Pages : 242
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Book Description
![Involvement of the Immediate Early Genes NGFI-A and Arc in Enriched Environment-induced Plasticity in the Central Nervous System [microform] PDF](https://books.google.com/books/content/images/frontcover/mnt6jwEACAAJ?fife=w80-h100)
Author: Raphael Pinaud
Publisher: National Library of Canada = Bibliothèque nationale du Canada
ISBN: 9780612665842
Category :
Languages : en
Pages : 242
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Book Description
Author: Ingrid Maria Nijholt
Publisher: Cuvillier Verlag
ISBN: 9783898734936
Category :
Languages : en
Pages : 181
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Book Description
Author: Raphael Pinaud
Publisher: Springer Science & Business Media
ISBN:
Category : Medical
Languages : en
Pages : 314
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Book Description
Immediate early genes (IEGs) are a class of genes that are rapidly expressed without new protein synthesis and, in most cases, in direct response to synaptic input. The most widely studied IEGs in neurobiology encode transcription factors, with two popular examples being c-fos and NGFI-A (a.k.a., zif268 , egr-1, krox-24 and zenk). The activity-dependent expression of most inducible transcription factors has enabled neuroscientists to use their expression as mapping tools for neuronal activation, thereby enhancing our understanding of the anatomical and functional organization of the central nervous system (CNS). IEGs, however, are known to encode not only transcription factors, but a much wider variety of proteins including signaling molecules, growth factors and cytoskeletal proteins. IEGs are therefore both directly and indirectly implicated in the dynamic functional and anatomical restructuring of the CNS that permits the rapid integration of new sensory experience with pre-existing or on-going neural function. Finally, recent evidence suggests that IEGs may also be implicated in the initiation or amplification of aberrant signaling in connection with neuropathological disorders. This book reviews and details experiments and theories that challenge the reader to expand their view on how IEG research is currently being used to advance our understanding of static and active brain circuits, enabling the processing, acquisition and storage of new information in healthy systems. In addition, we explore roles of IEGs in clinical neuropathology, with potential utility in molecular modeling, to highlight, on a go-forward basis, candidate mechanisms for novel targets in clinical intervention.
Author: Alessandro Sale
Publisher:
ISBN: 9781118931684
Category : Brain
Languages : en
Pages :
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Book Description
"Environmental Experience and Plasticity of the Developing Brain goes beyond the genetic basis of neurodevelopment. Chapters illuminate the external factors that can dramatically impact the brain early in life and, consequently, the eventual accomplishment of developmental milestones and the construction of adult behavior and personality. Authored and edited by leaders in this rapidly growing field, Environmental Experience and Plasticity of the Developing Brain not only surveys preexisting literature on the effects of environment versus genetics, but also discusses more recent studies on the impacts of neurodevelopment in terms of maternal stimulation, environmental enrichment and sensory deprivation. The book also includes key examples of environmental impacts on preexisting genetic syndromes leading to developmental disabilities. Focus is also given to the consequences of early adverse experience in primates, as well as neurobiological and behavioral consequences in institutionalized human children and the reversibility of such consequences. Environmental Experience and Plasticity of the Developing Brain encompasses a broad area of research in the field of developmental neurobiology and offers a unique combination of different examples of environmental factors affecting brain development and behavior"--Provided by publisher.
Author: Sharon L. Hirsh
Publisher: Cambridge University Press
ISBN: 9780521009362
Category : Art
Languages : en
Pages : 375
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Book Description
This is the first social history of the Symbolist movement, providing new definitions and theories for Symbolism and Decadence. Sharon Hirsh addresses issues such as spatial/street confrontations with the crowd, the diseased city, and the New Woman. Focusing on works by well known artists such as Van Gogh, Munch and Ensor, Hirsh also considers the works of artists who contributed in important ways to the Symbolist movement and the cities in which they worked.
Author: Michelle Facos
Publisher:
ISBN: 9780521815659
Category : Art
Languages : en
Pages : 297
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Book Description
At the turn of the twentieth century, nations, both sovereign and aspiring, feverishly worked to define, foster, and promote national identity. While historians have recognized the significance of this moment for modern identity formations, it has largely been neglected by art historians. Art, Culture and National Identity in Fin-de-Siècle Europe examines the phenomenon of politicized art and its connections to modernism. In eleven essays that focus on as many nations, an international team of authors explore the complex issues facing artists who helped to form a distinct national identity to audiences at home and abroad. The detailed case studies unravel the matrix of circumstances that fostered nationalistic developments, thereby offering a more nuanced understanding of European art and culture around 1900.
Author: Cotten Seiler
Publisher: University of Chicago Press
ISBN: 0226745651
Category : Transportation
Languages : en
Pages : 242
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Book Description
Rising gas prices, sprawl and congestion, global warming, even obesity—driving is a factor in many of the most contentious issues of our time. So how did we get here? How did automobile use become so vital to the identity of Americans? Republic of Drivers looks back at the period between 1895 and 1961—from the founding of the first automobile factory in America to the creation of the Interstate Highway System—to find out how driving evolved into a crucial symbol of freedom and agency. Cotten Seiler combs through a vast number of historical, social scientific, philosophical, and literary sources to illustrate the importance of driving to modern American conceptions of the self and the social and political order. He finds that as the figure of the driver blurred into the figure of the citizen, automobility became a powerful resource for women, African Americans, and others seeking entry into the public sphere. And yet, he argues, the individualistic but anonymous act of driving has also monopolized our thinking about freedom and democracy, discouraging the crafting of a more sustainable way of life. As our fantasies of the open road turn into fears of a looming energy crisis, Seiler shows us just how we ended up a republic of drivers—and where we might be headed.
Author: Donald W. Pfaff
Publisher: Springer Science & Business Media
ISBN: 3540792880
Category : Medical
Languages : en
Pages : 204
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Book Description
This book concentrates on two major topics: firstly, the molecular and neural biology of hormone actions relevant to normal social behaviors; and secondly, the clinical treatment of human patients in whom these behaviors have gone wrong.
Author: Victor D. LaValle
Publisher: Crown
ISBN:
Category : Fiction
Languages : en
Pages : 296
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Book Description
Something is wrong with Anthony, and it's getting worse. Schizophrenia runs in his family's blood, picking off an uncle here, a mother there, and has now found a home in Anthony's mind. The women in his life -- his mother, sister, and grandmother -- bring him home to Queens and try to fix him, but his presence slowly turns their home into a semi-suburban asylum.Anthony narrates the skewed story of his family's surreal adventures in an exploitative world, from black-market employers and neighborhood loansharks to bogus beauty pageants and bootleg medical clinics. In the tradition of misfit picaresques from The World According to Garp to Confederacy of Dunces, this is the story of a family trying to save themselves from the ravenous world and their own unraveling minds.
