Intrinsic mutagenesis PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Intrinsic mutagenesis PDF full book. Access full book title Intrinsic mutagenesis by Burnet MacFarlane. Download full books in PDF and EPUB format.
Author: Burnet MacFarlane
Publisher: Springer Science & Business Media
ISBN: 9401166064
Category : Medical
Languages : en
Pages : 245
Get Book Here
Book Description
This book is something which almost accidentally has developed very differently from how it was initially planned. The intention was to elaborate the part played by the immune system in ageing with the role of the thymus as central theme. It was to be essentially an expansion of a lecture I gave in 1970 and would inevitably have been concerned with much the same material as Walford's book, The Immunologic Theory of Aging, though from a different slant. What changed its character arose from a series of attempts to find logical connection between two findings that most gerontologists regard as axiomatic: that the lifespan of a mammal is genetically determined, and that the actual process of ageing is an accumulation of genetic error, of somatic mutations. It is possible that the connection is so indirect, circuitous and multiform that generations of detailed and unattractive research will be needed to elucidate it, or, more likely, the whole matter discarded as a non-problem. But a more inspiring approach does seem possible. The working hypothesis, which halfway through its writing became the new central theme of the book, arose when I was a member of a committee appointed by the Australian Academy of Science at the request of the Australian Government to advise on the danger from French nuclear tests in the South Pacific.
Author: Burnet MacFarlane
Publisher: Springer Science & Business Media
ISBN: 9401166064
Category : Medical
Languages : en
Pages : 245
Get Book Here
Book Description
This book is something which almost accidentally has developed very differently from how it was initially planned. The intention was to elaborate the part played by the immune system in ageing with the role of the thymus as central theme. It was to be essentially an expansion of a lecture I gave in 1970 and would inevitably have been concerned with much the same material as Walford's book, The Immunologic Theory of Aging, though from a different slant. What changed its character arose from a series of attempts to find logical connection between two findings that most gerontologists regard as axiomatic: that the lifespan of a mammal is genetically determined, and that the actual process of ageing is an accumulation of genetic error, of somatic mutations. It is possible that the connection is so indirect, circuitous and multiform that generations of detailed and unattractive research will be needed to elucidate it, or, more likely, the whole matter discarded as a non-problem. But a more inspiring approach does seem possible. The working hypothesis, which halfway through its writing became the new central theme of the book, arose when I was a member of a committee appointed by the Australian Academy of Science at the request of the Australian Government to advise on the danger from French nuclear tests in the South Pacific.
Author: Ashutosh Kumar
Publisher: Academic Press
ISBN: 0128092602
Category : Science
Languages : en
Pages : 352
Get Book Here
Book Description
Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. - Presents an up-to-date and in-depth review of the current state of mutagenesis research - Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors - Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials
Author: Ronnie Ann Rosenthal
Publisher: Springer Science & Business Media
ISBN: 1475734328
Category : Medical
Languages : en
Pages : 1102
Get Book Here
Book Description
Principles and Practice of Geriatric Surgery presents the fundamentals of surgical care for the fastest growing segment of the US population, providing a vital integration of operative strategies with the physiological changes of aging. Among the topics covered are the endocrine system, otolaryngology, respiratory system, cardiovascular system, GI system, hepatobiliary system, urogenital system, soft tissue and musculoskeletal system, neurosurgery, and transplantation.
Author: Macfarlane Burnet
Publisher: Cambridge University Press
ISBN: 9780521221146
Category : Science
Languages : en
Pages : 244
Get Book Here
Book Description
Author: Jacques Monod
Publisher:
ISBN: 9780140256468
Category : Biology
Languages : en
Pages : 198
Get Book Here
Book Description
Change and necessity is a statement of Darwinian natural selection as a process driven by chance necessity, devoid of purpose or intent.
Author: Munishwar Nath Gupta
Publisher: Elsevier
ISBN: 0323995349
Category : Science
Languages : en
Pages : 529
Get Book Here
Book Description
Structure and Intrinsic Disorder in Enzymology offers a direct, yet comprehensive presentation of the fundamental concepts, characteristics and functions of intrinsically disordered enzymes, along with valuable notes and technical insights powering new research in this emerging field. Here, more than twenty international experts examine protein flexibility and cryo-enzymology, hierarchies of intrinsic disorder, methods for measurement of disorder in proteins, bioinformatics tools for predictions of structure, disorder and function, protein promiscuity, protein moonlighting, globular enzymes, intrinsic disorder and allosteric regulation, protein crowding, intrinsic disorder in post-translational, and much more. Chapters also review methods for study, as well as evolving technology to support new research across academic, industrial and pharmaceutical labs. - Unifies the roles of intrinsic disorder and structure in the functioning of enzymes and proteins - Examines a range of enzyme and protein characteristics, their relationship to intrinsic disorder, and methods for study - Features chapter contributions from international leaders in the field
Author: B. Kirkwood
Publisher: Springer Science & Business Media
ISBN: 9400940971
Category : Science
Languages : en
Pages : 550
Get Book Here
Book Description
Molecular biology proceeds at unremitting pace to unfold new secrets of the living world. Biology, long regarded as an inexact companion to physics and chemistry, has undergone transformation. Now, chemical and physical principles are tools in understanding highly complex biomolecular processes, whose origin lies in a history of chance, constraint and natural selection. The accuracy of these processes, often remarkably high, is crucial to their self perpetuation, both individually and collectively, as ingredients of the organism as a whole. In this book are presented thirteen chapters which deal with various facets of the accuracy problem. Subjects covered include: the specificity of enzymes; the fidelity of synthesis of proteins; the replication and repair of DNA: general schemes for the enhancement of biological accuracy; selection for an optimal balance between the costs and benefits of accuracy; and the possible relevance of molecular mistakes to the process of ageing. The viewpoints are distinct, yet complementary, and the book as a whole offers to researchers and students the first comprehensive account of this growing field.
Author: W. Gary Flamm
Publisher: Hemisphere Pub
ISBN:
Category : Medical
Languages : en
Pages : 424
Get Book Here
Book Description
Author: Beatrice Singer
Publisher: Springer Science & Business Media
ISBN: 1461337720
Category : Medical
Languages : en
Pages : 352
Get Book Here
Book Description
This book originated in numerous Gordon Research Conferences and many other meetings of scientists working in chemistry, biophysics, biochemistry, and biology related to mutagenesis and carcinogenesis. It seemed the appro priate time to sit back and summarize the results of several decades of research in laboratories in different countries. We are very grateful to the Rockefeller Foundation for inviting us to formulate and begin writing the book at the Center for International Studies in Bellagio, Italy, where we were Resident Scholars. We are fortunate to have had the assistance of so many colleagues around the world who cheerfully sent original data, figures, and preprints and lis tened patiently to us as we worked out the various conflicting ideas in this fast-moving. field. The names of these scientists are found within the tables, figures, and references. There is one person whose contributions we especially wish to acknowl edge. Professor Heinz Fraenkel-Conrat was present at the inception of this book and throughout the writing encouraged and criticized in apprOximately equal proportion. Finally, his editing and amalgamation of our two styles gave us great comfort. B.S. D.G.
Author: Vincent J. Cristofalo, PhD
Publisher: Springer Publishing Company
ISBN: 0826164889
Category : Medical
Languages : en
Pages : 240
Get Book Here
Book Description
This volume presents a clear, concise overview of the current state of knowledge about the biology of aging ñ serving as both an invaluable graduate-level text and a key reference for practicing professionals. Over a dozen distinguished contributors probe the latest developments in our knowledge of why people age and how the process works. These authoritative chapters are not just written for biologists ñ but for gerontologists in general. Marks the tenth anniversary of the Annual Review of Gerontology and Geriatrics.
