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Author: Ding-Geng (Din) Chen
Publisher: CRC Press
ISBN: 1466504250
Category : Mathematics
Languages : en
Pages : 435
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Book Description
Interval-Censored Time-to-Event Data: Methods and Applications collects the most recent techniques, models, and computational tools for interval-censored time-to-event data. Top biostatisticians from academia, biopharmaceutical industries, and government agencies discuss how these advances are impacting clinical trials and biomedical research. Divided into three parts, the book begins with an overview of interval-censored data modeling, including nonparametric estimation, survival functions, regression analysis, multivariate data analysis, competing risks analysis, and other models for interval-censored data. The next part presents interval-censored methods for current status data, Bayesian semiparametric regression analysis of interval-censored data with monotone splines, Bayesian inferential models for interval-censored data, an estimator for identifying causal effect of treatment, and consistent variance estimation for interval-censored data. In the final part, the contributors use Monte Carlo simulation to assess biases in progression-free survival analysis as well as correct bias in interval-censored time-to-event applications. They also present adaptive decision making methods to optimize the rapid treatment of stroke, explore practical issues in using weighted logrank tests, and describe how to use two R packages. A practical guide for biomedical researchers, clinicians, biostatisticians, and graduate students in biostatistics, this volume covers the latest developments in the analysis and modeling of interval-censored time-to-event data. It shows how up-to-date statistical methods are used in biopharmaceutical and public health applications.
Author: Ding-Geng (Din) Chen
Publisher: CRC Press
ISBN: 1466504250
Category : Mathematics
Languages : en
Pages : 435
Get Book Here
Book Description
Interval-Censored Time-to-Event Data: Methods and Applications collects the most recent techniques, models, and computational tools for interval-censored time-to-event data. Top biostatisticians from academia, biopharmaceutical industries, and government agencies discuss how these advances are impacting clinical trials and biomedical research. Divided into three parts, the book begins with an overview of interval-censored data modeling, including nonparametric estimation, survival functions, regression analysis, multivariate data analysis, competing risks analysis, and other models for interval-censored data. The next part presents interval-censored methods for current status data, Bayesian semiparametric regression analysis of interval-censored data with monotone splines, Bayesian inferential models for interval-censored data, an estimator for identifying causal effect of treatment, and consistent variance estimation for interval-censored data. In the final part, the contributors use Monte Carlo simulation to assess biases in progression-free survival analysis as well as correct bias in interval-censored time-to-event applications. They also present adaptive decision making methods to optimize the rapid treatment of stroke, explore practical issues in using weighted logrank tests, and describe how to use two R packages. A practical guide for biomedical researchers, clinicians, biostatisticians, and graduate students in biostatistics, this volume covers the latest developments in the analysis and modeling of interval-censored time-to-event data. It shows how up-to-date statistical methods are used in biopharmaceutical and public health applications.
Author: Jianguo Sun
Publisher: Springer
ISBN: 0387371192
Category : Mathematics
Languages : en
Pages : 310
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Book Description
This book collects and unifies statistical models and methods that have been proposed for analyzing interval-censored failure time data. It provides the first comprehensive coverage of the topic of interval-censored data and complements the books on right-censored data. The focus of the book is on nonparametric and semiparametric inferences, but it also describes parametric and imputation approaches. This book provides an up-to-date reference for people who are conducting research on the analysis of interval-censored failure time data as well as for those who need to analyze interval-censored data to answer substantive questions.
Author: Kris Bogaerts
Publisher: CRC Press
ISBN: 1351643053
Category : Mathematics
Languages : en
Pages : 537
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Book Description
Survival Analysis with Interval-Censored Data: A Practical Approach with Examples in R, SAS, and BUGS provides the reader with a practical introduction into the analysis of interval-censored survival times. Although many theoretical developments have appeared in the last fifty years, interval censoring is often ignored in practice. Many are unaware of the impact of inappropriately dealing with interval censoring. In addition, the necessary software is at times difficult to trace. This book fills in the gap between theory and practice. Features: -Provides an overview of frequentist as well as Bayesian methods. -Include a focus on practical aspects and applications. -Extensively illustrates the methods with examples using R, SAS, and BUGS. Full programs are available on a supplementary website. The authors: Kris Bogaerts is project manager at I-BioStat, KU Leuven. He received his PhD in science (statistics) at KU Leuven on the analysis of interval-censored data. He has gained expertise in a great variety of statistical topics with a focus on the design and analysis of clinical trials. Arnošt Komárek is associate professor of statistics at Charles University, Prague. His subject area of expertise covers mainly survival analysis with the emphasis on interval-censored data and classification based on longitudinal data. He is past chair of the Statistical Modelling Society and editor of Statistical Modelling: An International Journal. Emmanuel Lesaffre is professor of biostatistics at I-BioStat, KU Leuven. His research interests include Bayesian methods, longitudinal data analysis, statistical modelling, analysis of dental data, interval-censored data, misclassification issues, and clinical trials. He is the founding chair of the Statistical Modelling Society, past-president of the International Society for Clinical Biostatistics, and fellow of ISI and ASA.
Author: Ding-Geng (Din) Chen
Publisher: CRC Press
ISBN: 1466504285
Category : Mathematics
Languages : en
Pages : 426
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Book Description
Interval-Censored Time-to-Event Data: Methods and Applications collects the most recent techniques, models, and computational tools for interval-censored time-to-event data. Top biostatisticians from academia, biopharmaceutical industries, and government agencies discuss how these advances are impacting clinical trials and biomedical research.Divid
Author: Ardo van den Hout
Publisher: CRC Press
ISBN: 1315356732
Category : Mathematics
Languages : en
Pages : 323
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Book Description
Multi-State Survival Models for Interval-Censored Data introduces methods to describe stochastic processes that consist of transitions between states over time. It is targeted at researchers in medical statistics, epidemiology, demography, and social statistics. One of the applications in the book is a three-state process for dementia and survival in the older population. This process is described by an illness-death model with a dementia-free state, a dementia state, and a dead state. Statistical modelling of a multi-state process can investigate potential associations between the risk of moving to the next state and variables such as age, gender, or education. A model can also be used to predict the multi-state process. The methods are for longitudinal data subject to interval censoring. Depending on the definition of a state, it is possible that the time of the transition into a state is not observed exactly. However, when longitudinal data are available the transition time may be known to lie in the time interval defined by two successive observations. Such an interval-censored observation scheme can be taken into account in the statistical inference. Multi-state modelling is an elegant combination of statistical inference and the theory of stochastic processes. Multi-State Survival Models for Interval-Censored Data shows that the statistical modelling is versatile and allows for a wide range of applications.
Author: Stef van Buuren
Publisher: CRC Press
ISBN: 0429960352
Category : Mathematics
Languages : en
Pages : 444
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Book Description
Missing data pose challenges to real-life data analysis. Simple ad-hoc fixes, like deletion or mean imputation, only work under highly restrictive conditions, which are often not met in practice. Multiple imputation replaces each missing value by multiple plausible values. The variability between these replacements reflects our ignorance of the true (but missing) value. Each of the completed data set is then analyzed by standard methods, and the results are pooled to obtain unbiased estimates with correct confidence intervals. Multiple imputation is a general approach that also inspires novel solutions to old problems by reformulating the task at hand as a missing-data problem. This is the second edition of a popular book on multiple imputation, focused on explaining the application of methods through detailed worked examples using the MICE package as developed by the author. This new edition incorporates the recent developments in this fast-moving field. This class-tested book avoids mathematical and technical details as much as possible: formulas are accompanied by verbal statements that explain the formula in accessible terms. The book sharpens the reader’s intuition on how to think about missing data, and provides all the tools needed to execute a well-grounded quantitative analysis in the presence of missing data.
Author: Mara Tableman
Publisher: CRC Press
ISBN: 0203501411
Category : Mathematics
Languages : en
Pages : 277
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Book Description
Survival Analysis Using S: Analysis of Time-to-Event Data is designed as a text for a one-semester or one-quarter course in survival analysis for upper-level or graduate students in statistics, biostatistics, and epidemiology. Prerequisites are a standard pre-calculus first course in probability and statistics, and a course in applied linear regression models. No prior knowledge of S or R is assumed. A wide choice of exercises is included, some intended for more advanced students with a first course in mathematical statistics. The authors emphasize parametric log-linear models, while also detailing nonparametric procedures along with model building and data diagnostics. Medical and public health researchers will find the discussion of cut point analysis with bootstrap validation, competing risks and the cumulative incidence estimator, and the analysis of left-truncated and right-censored data invaluable. The bootstrap procedure checks robustness of cut point analysis and determines cut point(s). In a chapter written by Stephen Portnoy, censored regression quantiles - a new nonparametric regression methodology (2003) - is developed to identify important forms of population heterogeneity and to detect departures from traditional Cox models. By generalizing the Kaplan-Meier estimator to regression models for conditional quantiles, this methods provides a valuable complement to traditional Cox proportional hazards approaches.
Author: John P. Klein
Publisher: Springer Science & Business Media
ISBN: 1475727283
Category : Medical
Languages : en
Pages : 508
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Book Description
Making complex methods more accessible to applied researchers without an advanced mathematical background, the authors present the essence of new techniques available, as well as classical techniques, and apply them to data. Practical suggestions for implementing the various methods are set off in a series of practical notes at the end of each section, while technical details of the derivation of the techniques are sketched in the technical notes. This book will thus be useful for investigators who need to analyse censored or truncated life time data, and as a textbook for a graduate course in survival analysis, the only prerequisite being a standard course in statistical methodology.
Author: Edward H. Livingston
Publisher: McGraw Hill Professional
ISBN: 1260455335
Category : Medical
Languages : en
Pages : 529
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Book Description
The world-renowned experts at JAMA® explain statistical analysis and the methods used in medical research Written in the language and style appropriate for clinicians and researchers, this new JAMA Guide to Statistics and Methods provides explanations and expert discussion of the statistical analytic approaches and methods used in the medical research reported in articles appearing in JAMA and the JAMA Network journals. This addition to the JAMAevidence® series is particularly timely and necessary because today’s physicians and other health care professionals must pursue lifelong learning to keep up with the ever-expanding universe of new medical science and evidence-based clinical information. Readers and users of research articles must have a firm grasp of the myriad new statistical, analytic, and methodologic approaches used in contemporary medical studies. To provide concrete examples, the explanations in the book link to research articles that incorporate the specific statistical test or methodological approach being discussed.
Author: Richard J Cook
Publisher: CRC Press
ISBN: 1351646052
Category : Mathematics
Languages : en
Pages : 500
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Book Description
Multistate Models for the Analysis of Life History Data provides the first comprehensive treatment of multistate modeling and analysis, including parametric, nonparametric and semiparametric methods applicable to many types of life history data. Special models such as illness-death, competing risks and progressive processes are considered, as well as more complex models. The book provides both theoretical development and illustrations of analysis based on data from randomized trials and observational cohort studies in health research. It features: Discusses a wide range of applications of multistate models, Presents methods for both continuously and intermittently observed life history processes, Gives a thorough discussion of conditionally independent censoring and observation processes, Discusses models with random effects and joint models for two or more multistate processes, Discusses and illustrates software for multistate analysis that is available in R, Target audience includes those engaged in research and applications involving multistate models.
