Interfacial Transport Processes in Microfluidic Systems for Precision Surface Enhanced Raman Spectroscopy

Interfacial Transport Processes in Microfluidic Systems for Precision Surface Enhanced Raman Spectroscopy PDF Author: Chrysafis Andreou
Publisher:
ISBN: 9781303730733
Category :
Languages : en
Pages : 152

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Book Description
In this way the interactions of very small numbers of the relevant species can be investigated. Together, SERS and microfluidics provide a powerful platform for detection of a wide range of analytes, with unparalleled specificity, precision, and accuracy.

Interfacial Transport Processes in Microfluidic Systems for Precision Surface Enhanced Raman Spectroscopy

Interfacial Transport Processes in Microfluidic Systems for Precision Surface Enhanced Raman Spectroscopy PDF Author: Chrysafis Andreou
Publisher:
ISBN: 9781303730733
Category :
Languages : en
Pages : 152

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Book Description
In this way the interactions of very small numbers of the relevant species can be investigated. Together, SERS and microfluidics provide a powerful platform for detection of a wide range of analytes, with unparalleled specificity, precision, and accuracy.

Transport Processes in Free Surface Microfluidics

Transport Processes in Free Surface Microfluidics PDF Author: Brian Douglas Piorek
Publisher:
ISBN: 9780549987956
Category :
Languages : en
Pages : 266

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Book Description
An investigation was conducted to examine the dominant fluid transport physics at the macro, micro, and molecular scale. Three novel techniques were developed to elucidate the fluid flow fields occurring in microscale and nanoscale fluidic systems. These techniques were then used to design and investigate a novel free-surface microfluidic system capable of delivering sustained and controlled flows ranging from 0 -- 1000 mum/s. The microsystem was then used to develop a sensitive and selective chemical detector capable of identifying certain gas-phase molecules present in the nearby atmosphere. The detector performs molecular recognition of gaseous compounds in the adjacent atmosphere by surface enhanced Raman spectroscopy and the transport properties of the microfluidic system are designed to maximize vapor detection capability. Chemical detection sensitivity of gaseous compounds is better than PPT. Vapors emanated from some nearby solid compounds are also detected at room temperature, including the gas-phase molecules naturally emitted from the explosive compounds: TNT, TATP, picric acid, RDX; and from narcotic samples such as cocaine.

Transport Processes at the Air/liquid Interface in Microfluidic Systems

Transport Processes at the Air/liquid Interface in Microfluidic Systems PDF Author: Meysam Rezaei Barmi
Publisher:
ISBN: 9781303540301
Category :
Languages : en
Pages : 125

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Book Description
For a well stirred droplet, the optimal condition for SERS detection was found to be at kcNPtevap = 0.3, which is a product of the dimerization rate constant (k), the concentration of nanoparticles (cNP), and the droplet evaporation time (tevap). Near maximal signal is observed which defines a time window during which trace analytes can be measured. The results of the simulations revealed a very good agreement with experimentally acquired SERS spectra using gas-phase 1,4-BDT as a model analyte. Finally, the detection of Nicotine from breath was performed to prove the ability of this platform for the breath diagnostics.

Interfacial Transport Processes and Rheology

Interfacial Transport Processes and Rheology PDF Author: Howard Brenner
Publisher: Elsevier
ISBN: 1483292274
Category : Science
Languages : en
Pages : 577

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Book Description
This textbook is designed to provide the theory, methods of measurement, and principal applications of the expanding field of interfacial hydrodynamics. It is intended to serve the research needs of both academic and industrial scientists, including chemical or mechanical engineers, material and surface scientists, physical chemists, chemical and biophysicists, rheologists, physiochemical hydrodynamicists, and applied mathematicians (especially those with interests in viscous fluid mechanics and continuum mechanics).As a textbook it provides materials for a one- or two-semester graduate-level course in interfacial transport processes. It may also be noted that, while separate practical and theoretical subdivisions of material have been introduced, a kind of cross-emphasis is often stressed: (i) to the academic scientist, or the importance of understanding major applications of interfacial transport; and (ii) to the industrial scientist, of the importance of understanding the underlying theory.

Interfacial Fluid Dynamics and Transport Processes

Interfacial Fluid Dynamics and Transport Processes PDF Author: Ranga Narayanan
Publisher: Springer Science & Business Media
ISBN: 9783540405832
Category : Science
Languages : en
Pages : 396

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Book Description
The present set of lectures and tutorial reviews deals with various topical aspects related to instabilities of interfacial processes and driven flows from both the theoretical and experimental point of views. New research has been spurred by demands for many applications in material sciences (melting, solidification, electro deposition), biomedical engineering and processing in microgravity environments. This book is intended as both a modern source of reference for researchers in the field as well as an introduction to postgraduate students and non-specialists from related areas.

Surface-Enhanced Raman Scattering

Surface-Enhanced Raman Scattering PDF Author: Zhong-Qun Tian
Publisher: John Wiley & Sons Incorporated
ISBN: 9780470068083
Category : Science
Languages : en
Pages : 400

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Book Description
Surface-Enhanced Raman Spectroscopy: Principles, Experiments, and Applications is a comprehensive, up to date, and balanced treatment of the theoretical and practical aspects of Surface-Enhanced Raman Scattering (SERS), a useful branch of spectroscopy for several areas of science. This book describes the basic principles of SERS, including SERS mechanisms, performing SERS measurements, and interpreting data. Also emphasized are applications in electrochemistry; catalysis; surface processing and corrosion; Self-Assemble-Layer and L-B Films; polymer science; biology; medicine and drug analysis; sensors; fuel cells; forensics; and archaeology. It is an essential guide for student and professional analytical chemists.

Development of Microfluidic Devices for in Situ Investigation of Cells Using Surface-enhanced Raman Spectroscopy

Development of Microfluidic Devices for in Situ Investigation of Cells Using Surface-enhanced Raman Spectroscopy PDF Author: Yu-Han Ho
Publisher:
ISBN:
Category :
Languages : en
Pages : 45

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Book Description
Surface-enhanced Raman spectroscopy (SERS) has immerged as a power analytical and sensing technique for many applications in biomedical diagnosis, life sciences, food safety, and environment monitoring because of its molecular specificity and high sensitivity. The inactive Raman scattering of water molecule makes SERS a suitable tool for studying biological systems. Microfluidic devices have also attracted a tremendous interest for the aforementioned applications. By integrating SERS-active substrates with microfluidic devices, it offers a new capability for in situ investigation of biological systems, their dynamic behaviors, and response to drugs or microenvironment changes. In this work, we designed and fabricated a microfluidic device with SERS-active substrates surrounding by cell traps in microfluidic channels for in situ study of live cells using SERS. The SERS-active substrates are quasi-3D plasmonic nanostructure array (Q3D-PNA) made in h-PDMS/PMDS with physically separated gold film with nanoholes op top and gold nanodisks at the bottom of nanowells. The Q3D-PNAs with the strongest local electric fields (hot spots) at the top and bottom water/Au interfaces, designed by 3D finite-difference time-domain (3D-FDTD) electromagnetic simulations, were placed at the up and down stream of the microfluidic channel for sensitive analysis of cells and small components, respectively. The microfluidic device was fabricated via soft lithography. We demonstrated that normal (COS-7) and cancer (HpeG2) cells were captured on the Q3D-PNAs and investigated in situ using SERS.

Interfacial Fluid Dynamics and Transport Processes

Interfacial Fluid Dynamics and Transport Processes PDF Author: Ranga Narayanan
Publisher: Springer
ISBN: 9783662143773
Category : Science
Languages : en
Pages : 370

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Book Description
The present set of lectures and tutorial reviews deals with various topical aspects related to instabilities of interfacial processes and driven flows from both the theoretical and experimental point of views. New research has been spurred by demands for many applications in material sciences (melting, solidification, electro deposition), biomedical engineering and processing in microgravity environments. This book is intended as both a modern source of reference for researchers in the field as well as an introduction to postgraduate students and non-specialists from related areas.

Interfacial Transport and Reactions in a Multiphase Microfluidic System

Interfacial Transport and Reactions in a Multiphase Microfluidic System PDF Author: Yali Zhang
Publisher:
ISBN: 9789036540773
Category :
Languages : en
Pages : 106

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Book Description


Enzyme Engineering and Evolution: General Methods

Enzyme Engineering and Evolution: General Methods PDF Author:
Publisher: Academic Press
ISBN: 0128211504
Category : Science
Languages : en
Pages : 362

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Book Description
This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series