Author: Nikos Karamanos
Publisher: Walter de Gruyter
ISBN: 3110258773
Category : Science
Languages : en
Pages : 940
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Book Description
Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting. It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden
Author: Monica Reynolds
Publisher: University of Pennsylvania Press
ISBN: 1512806056
Category : Medical
Languages : en
Pages : 284
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Book Description
Proceedings of a symposium, satellite to the 24th International Congress of Physiological Sciences, University of Pennsylvania.
Author: Dil Afroze
Publisher: BoD – Books on Demand
ISBN: 1789239613
Category : Medical
Languages : en
Pages : 127
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Book Description
This book offers a comprehensive overview of recent developments in the field of breast cancer biology. It is a complete and descriptive reference on motioning pathways and new treatment options for the future transnational scientists and clinicians working on cancer research and treatment. We greatly appreciate the work of all the contributors to this book. They have brought with them tremendous diversity of perspectives and fields, which is truly reflective of the complexity of the topic, and they have come together in this project to serve as the node of multidisciplinary collaboration in this field. Finally, we must acknowledge the thousands of cancer patients who have participated in the studies, and who have inspired us to gather information to significantly progress knowledge in the field in recent years.
Author: William J. Hoskins
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781746892
Category : Medical
Languages : en
Pages : 1466
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Book Description
This updated Fourth Edition provides comprehensive coverage of the biology of gynecologic cancer, the therapeutic modalities available, and the diagnosis and treatment of site-specific malignancies. Because of the importance of multimodality treatment, the site-specific chapters are co-authored by a surgical oncologist, a medical oncologist, a radiation oncologist, and a pathologist. A significant portion of this edition focuses on monoclonal antibodies, vaccines, and gene directed therapies and how they can greatly improve treatment outcomes. A new chapter on end-of-life care is also included. Three distinguished new editors—Richard R. Barakat, MD, Maurie Markman, MD, and Marcus E. Randall, MD—now join the editorial team.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1930
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Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author: David A. Frank
Publisher: Springer Science & Business Media
ISBN: 1402073402
Category : Medical
Languages : en
Pages : 358
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Book Description
One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Author: Nilufer Bulut
Publisher: BoD – Books on Demand
ISBN: 1789235669
Category : Medical
Languages : en
Pages : 228
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Book Description
The book 'Breast Cancer and Surgery' summarizes the treatment options from the onset of breast carcinogenesis to early-local advanced and metastatic breast cancer. Chemotherapy alternatives, drug resistance and local and surgical treatment preferences are extensively discussed and this information is especially directed at clinicians, researchers, and students. This book includes a comparison between different chemotherapy agents and targeted therapies with published phase II-III studies. The importance of palliative care and dietary supplements administered during the treatment course in reducing the comorbidity of patients is emphasized. Photodynamic treatments have been included in this book. A comprehensive and up-to-date information exchange that can be accessed through a single source is provided to all researchers interested in breast cancer.
Author: Phuc Van Pham
Publisher: BoD – Books on Demand
ISBN: 9535129996
Category : Medical
Languages : en
Pages : 570
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Book Description
Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.
Author: Haim Werner
Publisher: MDPI
ISBN: 3036507701
Category : Science
Languages : en
Pages : 196
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Book Description
This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology.
Author: Gerald Litwack
Publisher: Academic Press
ISBN: 0128208090
Category : Science
Languages : en
Pages : 374
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Book Description
Aquaporin Regulation, Volume 112, the latest release in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters highlighting Perspectives on the evolution of aquaporin superfamily, Structure and dynamics of aquaporin-1, Selectivity and Transport in Aquaporins from Molecular Simulation Studies, Aquaporin regulation in metabolic organs, Phosphorylation of human AQP2 and its role in trafficking, Regulation of Aquaporin-2 by RNA Interference, Aquaporin Regulation: Lessons from Secretory Vesicles, CFTR Regulation of Aquaporin-mediated Water Transport, Glucocorticoid Gene Regulation of Aquaporin-7, and much more.
