Insights into Anal Dysplasia: From Molecular Mechanisms to Precision Medicine PDF Download
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Author: Dr. Spineanu Eugenia
Publisher: Dr. Spineanu Eugenia
ISBN:
Category : Medical
Languages : en
Pages : 95
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Book Description
Embark on a comprehensive journey through the intricacies of anal dysplasia in this groundbreaking treatise, titled 'Insights into Anal Dysplasia: From Molecular Mechanisms to Precision Medicine.' This meticulously crafted exploration navigates the multifaceted landscape of anal dysplasia, offering a panoramic view that spans from defining the condition to unraveling its molecular intricacies and advancing towards precision medicine approaches. The treatise begins with a profound exploration of the definition and scope of anal dysplasia, establishing a foundation for readers unfamiliar with the intricacies of this condition. Delving into historical perspectives, the narrative unfolds, tracing the evolution of knowledge and diagnostic paradigms, emphasizing the ongoing commitment to advancements in healthcare. Epidemiology and risk factors, crucial elements in understanding the prevalence and determinants of anal dysplasia, are dissected with precision. The treatise then transitions seamlessly to a detailed examination of the anatomical underpinnings, both gross and microscopic, providing a nuanced understanding of the structural complexities involved.
Author: Dr. Spineanu Eugenia
Publisher: Dr. Spineanu Eugenia
ISBN:
Category : Medical
Languages : en
Pages : 95
Get Book Here
Book Description
Embark on a comprehensive journey through the intricacies of anal dysplasia in this groundbreaking treatise, titled 'Insights into Anal Dysplasia: From Molecular Mechanisms to Precision Medicine.' This meticulously crafted exploration navigates the multifaceted landscape of anal dysplasia, offering a panoramic view that spans from defining the condition to unraveling its molecular intricacies and advancing towards precision medicine approaches. The treatise begins with a profound exploration of the definition and scope of anal dysplasia, establishing a foundation for readers unfamiliar with the intricacies of this condition. Delving into historical perspectives, the narrative unfolds, tracing the evolution of knowledge and diagnostic paradigms, emphasizing the ongoing commitment to advancements in healthcare. Epidemiology and risk factors, crucial elements in understanding the prevalence and determinants of anal dysplasia, are dissected with precision. The treatise then transitions seamlessly to a detailed examination of the anatomical underpinnings, both gross and microscopic, providing a nuanced understanding of the structural complexities involved.
Author: Kevin M. Haigis, Ph.D.
Publisher: Springer Science & Business Media
ISBN: 146148412X
Category : Medical
Languages : en
Pages : 319
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Book Description
Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.
Author: Sushil K. Sarna
Publisher: Biota Publishing
ISBN: 1615041516
Category : Medical
Languages : en
Pages : 159
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Book Description
Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of propagation of a GMC are several-fold larger than those of an RPC. The enteric neurons and smooth muscle cells are the core regulators of all three types of contractions. The regulation of contractions by these mechanisms is modifiable by extrinsic factors: CNS, autonomic neurons, hormones, inflammatory mediators, and stress mediators. Only the GMCs produce descending inhibition, which accommodates the large bolus being propelled without increasing muscle tone. The strong compression of the colon wall generates afferent signals that are below nociceptive threshold in healthy subjects. However, these signals become nociceptive; if the amplitudes of GMCs increase, afferent nerves become hypersensitive, or descending inhibition is impaired. The GMCs also provide the force for rapid propulsion of feces and descending inhibition to relax the internal anal sphincter during defecation. The dysregulation of GMCs is a major factor in colonic motility disorders: irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and diverticular disease (DD). Frequent mass movements by GMCs cause diarrhea in diarrhea predominant IBS, IBD, and DD, while a decrease in the frequency of GMCs causes constipation. The GMCs generate the afferent signals for intermittent short-lived episodes of abdominal cramping in these disorders. Epigenetic dysregulation due to adverse events in early life is one of the major factors in generating the symptoms of IBS in adulthood.
Author: John D. Potter
Publisher: Springer
ISBN: 9780387095677
Category : Medical
Languages : en
Pages : 309
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Book Description
Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.
Author: George Klein
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 874
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Book Description
Author: Melvin L. DePamphilis
Publisher: CSHL Press
ISBN: 0879697660
Category : Medical
Languages : en
Pages : 814
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Book Description
At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA! And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? This book addresses these questions by presenting a thorough analysis of the molecular events that govern DNA replication in eukaryotic cells. The association between genome replication and cell proliferation, disease pathogenesis, and the development of targeted therapeutics is also addressed. At least 160 proteins are involved in replicating the human genome, and at least 40 diseases are caused by aberrant DNA replication, 35 by mutations in genes required for DNA replication or repair, 7 by mutations generated during mitochondrial DNA replication, and more than 40 by DNA viruses. Consequently, a growing number of therapeutic drugs are targeted to DNA replication proteins. This authoritative volume provides a rich source of information for researchers, physicians, and teachers, and will stimulate thinking about the relevance of DNA replication to human disease.
Author: James A. Radosevich
Publisher: Springer Science & Business Media
ISBN: 940075437X
Category : Medical
Languages : en
Pages : 202
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Book Description
“HPV and Cancer” is a concise read that covers all aspects of the Human Papilloma Virus as it relates to human cancers. While written by professionals, it design to be understandable by those that are not in the field, yet it has the technical details that professionals want to stay abreast of this changing field. The book starts out the history of HPV and progresses into the molecular biology of the virus and our current understand of the structure and functions of the proteins and genes it encodes. We then look at the dynamic trends of this infectious agent in the human population, how it interacts with human cells, and the role it plays with other organisms to produce both benign and malignant tumors. Lastly, there is a discussion about a new vaccine for HPV and the hopes that are held by many to change the trends with this virus and the associated cancers it produces.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1364
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Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author: Robert C. Bast, Jr.
Publisher: John Wiley & Sons
ISBN: 1118934695
Category : Medical
Languages : en
Pages : 2003
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Book Description
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author: Emanuel Lebenthal
Publisher: Raven Press (ID)
ISBN:
Category : Medical
Languages : en
Pages : 854
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Book Description
