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Author: Jesus M. Cortés
Publisher: Frontiers Media SA
ISBN: 2889195023
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
Languages : en
Pages : 192
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Book Description
The aim of this Research Topic is to discuss the state of the art on the use of Information-based methods in the analysis of neuroimaging data. Information-based methods, typically built as extensions of the Shannon Entropy, are at the basis of model-free approaches which, being based on probability distributions rather than on specific expectations, can account for all possible non-linearities present in the data in a model-independent fashion. Mutual Information-like methods can also be applied on interacting dynamical variables described by time-series, thus addressing the uncertainty reduction (or information) in one variable by conditioning on another set of variables. In the last years, different Information-based methods have been shown to be flexible and powerful tools to analyze neuroimaging data, with a wide range of different methodologies, including formulations-based on bivariate vs multivariate representations, frequency vs time domains, etc. Apart from methodological issues, the information bit as a common unit represents a convenient way to open the road for comparison and integration between different measurements of neuroimaging data in three complementary contexts: Structural Connectivity, Dynamical (Functional and Effective) Connectivity, and Modelling of brain activity. Applications are ubiquitous, starting from resting state in healthy subjects to modulations of consciousness and other aspects of pathophysiology. Mutual Information-based methods have provided new insights about common-principles in brain organization, showing the existence of an active default network when the brain is at rest. It is not clear, however, how this default network is generated, the different modules are intra-interacting, or disappearing in the presence of stimulation. Some of these open-questions at the functional level might find their mechanisms on their structural correlates. A key question is the link between structure and function and the use of structural priors for the understanding of the functional connectivity measures. As effective connectivity is concerned, recently a common framework has been proposed for Transfer Entropy and Granger Causality, a well-established methodology originally based on autoregressive models. This framework can open the way to new theories and applications. This Research Topic brings together contributions from researchers from different backgrounds which are either developing new approaches, or applying existing methodologies to new data, and we hope it will set the basis for discussing the development and validation of new Information-based methodologies for the understanding of brain structure, function, and dynamics.
Author: Jesus M. Cortés
Publisher: Frontiers Media SA
ISBN: 2889195023
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
Languages : en
Pages : 192
Get Book Here
Book Description
The aim of this Research Topic is to discuss the state of the art on the use of Information-based methods in the analysis of neuroimaging data. Information-based methods, typically built as extensions of the Shannon Entropy, are at the basis of model-free approaches which, being based on probability distributions rather than on specific expectations, can account for all possible non-linearities present in the data in a model-independent fashion. Mutual Information-like methods can also be applied on interacting dynamical variables described by time-series, thus addressing the uncertainty reduction (or information) in one variable by conditioning on another set of variables. In the last years, different Information-based methods have been shown to be flexible and powerful tools to analyze neuroimaging data, with a wide range of different methodologies, including formulations-based on bivariate vs multivariate representations, frequency vs time domains, etc. Apart from methodological issues, the information bit as a common unit represents a convenient way to open the road for comparison and integration between different measurements of neuroimaging data in three complementary contexts: Structural Connectivity, Dynamical (Functional and Effective) Connectivity, and Modelling of brain activity. Applications are ubiquitous, starting from resting state in healthy subjects to modulations of consciousness and other aspects of pathophysiology. Mutual Information-based methods have provided new insights about common-principles in brain organization, showing the existence of an active default network when the brain is at rest. It is not clear, however, how this default network is generated, the different modules are intra-interacting, or disappearing in the presence of stimulation. Some of these open-questions at the functional level might find their mechanisms on their structural correlates. A key question is the link between structure and function and the use of structural priors for the understanding of the functional connectivity measures. As effective connectivity is concerned, recently a common framework has been proposed for Transfer Entropy and Granger Causality, a well-established methodology originally based on autoregressive models. This framework can open the way to new theories and applications. This Research Topic brings together contributions from researchers from different backgrounds which are either developing new approaches, or applying existing methodologies to new data, and we hope it will set the basis for discussing the development and validation of new Information-based methodologies for the understanding of brain structure, function, and dynamics.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309164915
Category : Social Science
Languages : en
Pages : 280
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Book Description
By 2030 there will be about 70 million people in the United States who are older than 64. Approximately 26 percent of these will be racial and ethnic minorities. Overall, the older population will be more diverse and better educated than their earlier cohorts. The range of late-life outcomes is very dramatic with old age being a significantly different experience for financially secure and well-educated people than for poor and uneducated people. The early mission of behavioral science research focused on identifying problems of older adults, such as isolation, caregiving, and dementia. Today, the field of gerontology is more interdisciplinary. When I'm 64 examines how individual and social behavior play a role in understanding diverse outcomes in old age. It also explores the implications of an aging workforce on the economy. The book recommends that the National Institute on Aging focus its research support in social, personality, and life-span psychology in four areas: motivation and behavioral change; socioemotional influences on decision-making; the influence of social engagement on cognition; and the effects of stereotypes on self and others. When I'm 64 is a useful resource for policymakers, researchers and medical professionals.
Author: Mark Jenkinson
Publisher: Oxford University Press
ISBN: 0198816308
Category : Medical
Languages : en
Pages : 277
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Book Description
This accessible primer gives an introduction to the wide array of MRI-based neuroimaging methods that are used in research. It provides an overview of the fundamentals of what different MRI modalities measure, what artifacts commonly occur, the essentials of the analysis, and common 'pipelines'.
Author: Yao Wu
Publisher: Frontiers Media SA
ISBN: 2832511899
Category : Science
Languages : en
Pages : 201
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Book Description
Author: Hernando Ombao
Publisher: CRC Press
ISBN: 1482220989
Category : Mathematics
Languages : en
Pages : 702
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Book Description
This book explores various state-of-the-art aspects behind the statistical analysis of neuroimaging data. It examines the development of novel statistical approaches to model brain data. Designed for researchers in statistics, biostatistics, computer science, cognitive science, computer engineering, biomedical engineering, applied mathematics, physics, and radiology, the book can also be used as a textbook for graduate-level courses in statistics and biostatistics or as a self-study reference for Ph.D. students in statistics, biostatistics, psychology, neuroscience, and computer science.
Author: Ariel Rokem
Publisher: Princeton University Press
ISBN: 0691222746
Category : Science
Languages : en
Pages : 393
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Book Description
Data science methods and tools—including programming, data management, visualization, and machine learning—and their application to neuroimaging research As neuroimaging turns toward data-intensive discovery, researchers in the field must learn to access, manage, and analyze datasets at unprecedented scales. Concerns about reproducibility and increased rigor in reporting of scientific results also demand higher standards of computational practice. This book offers neuroimaging researchers an introduction to data science, presenting methods, tools, and approaches that facilitate automated, reproducible, and scalable analysis and understanding of data. Through guided, hands-on explorations of openly available neuroimaging datasets, the book explains such elements of data science as programming, data management, visualization, and machine learning, and describes their application to neuroimaging. Readers will come away with broadly relevant data science skills that they can easily translate to their own questions. • Fills the need for an authoritative resource on data science for neuroimaging researchers • Strong emphasis on programming • Provides extensive code examples written in the Python programming language • Draws on openly available neuroimaging datasets for examples • Written entirely in the Jupyter notebook format, so the code examples can be executed, modified, and re-executed as part of the learning process
Author:
Publisher: Elsevier
ISBN: 008047859X
Category : Medical
Languages : en
Pages : 347
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Book Description
Consisting of two separate volumes, Neuroimaging provides a state-of-the-art review of a broad range of neuroimaging techniques applied to both clinical and research settings. The breadth of the methods covered is matched by the depth of description of the theoretical background. Part A focuses on the cutting edge of research methodologies, providing a foundation for both established and evolving techniques. These include voxel-based morphometry using structural MRI, functional MRI, perfusion MRI, diffusion tensor imaging, near-infrared spectroscopy and the technique of combining EEG and fMRI studies. Two chapters are devoted to describing methods for studying brain responses and neural models, focusing on functional connectivity, effective connectivity, dynamic causal modeling, and large-scale neural models. The important role played by brain atlases in facilitating the study of normal and diseased brain populations is described in one chapter, and the concept of neuroimaging data bases as a future resource for scientific discovery is elucidated in another. The two parts of Neuroimaging complement each other providing in-depth information on a broad range of routine and cutting edge techniques that is not available in any other text. This book is superbly written and beautifully illustrated by contributors working at the top of their chosen specialty.* Serves as an up-to-date review of cutting-edge neuroimaging techniques * Exquisitely illustrated * Authoritatively written by leading researchers
Author: Michel Dojat
Publisher: Frontiers Media SA
ISBN: 2889452603
Category :
Languages : en
Pages : 141
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Book Description
Several recent papers underline methodological points that limit the validity of published results in imaging studies in the life sciences and especially the neurosciences (Carp, 2012; Ingre, 2012; Button et al., 2013; Ioannidis, 2014). At least three main points are identified that lead to biased conclusions in research findings: endemic low statistical power and, selective outcome and selective analysis reporting. Because of this, and in view of the lack of replication studies, false discoveries or solutions persist. To overcome the poor reliability of research findings, several actions should be promoted including conducting large cohort studies, data sharing and data reanalysis. The construction of large-scale online databases should be facilitated, as they may contribute to the definition of a “collective mind” (Fox et al., 2014) facilitating open collaborative work or “crowd science” (Franzoni and Sauermann, 2014). Although technology alone cannot change scientists’ practices (Wicherts et al., 2011; Wallis et al., 2013, Poldrack and Gorgolewski 2014; Roche et al. 2014), technical solutions should be identified which support a more “open science” approach. Also, the analysis of the data plays an important role. For the analysis of large datasets, image processing pipelines should be constructed based on the best algorithms available and their performance should be objectively compared to diffuse the more relevant solutions. Also, provenance of processed data should be ensured (MacKenzie-Graham et al., 2008). In population imaging this would mean providing effective tools for data sharing and analysis without increasing the burden on researchers. This subject is the main objective of this research topic (RT), cross-listed between the specialty section “Computer Image Analysis” of Frontiers in ICT and Frontiers in Neuroinformatics. Firstly, it gathers works on innovative solutions for the management of large imaging datasets possibly distributed in various centers. The paper of Danso et al. describes their experience with the integration of neuroimaging data coming from several stroke imaging research projects. They detail how the initial NeuroGrid core metadata schema was gradually extended for capturing all information required for future metaanalysis while ensuring semantic interoperability for future integration with other biomedical ontologies. With a similar preoccupation of interoperability, Shanoir relies on the OntoNeuroLog ontology (Temal et al., 2008; Gibaud et al., 2011; Batrancourt et al., 2015), a semantic model that formally described entities and relations in medical imaging, neuropsychological and behavioral assessment domains. The mechanism of “Study Card” allows to seamlessly populate metadata aligned with the ontology, avoiding fastidious manual entrance and the automatic control of the conformity of imported data with a predefined study protocol. The ambitious objective with the BIOMIST platform is to provide an environment managing the entire cycle of neuroimaging data from acquisition to analysis ensuring full provenance information of any derived data. Interestingly, it is conceived based on the product lifecycle management approach used in industry for managing products (here neuroimaging data) from inception to manufacturing. Shanoir and BIOMIST share in part the same OntoNeuroLog ontology facilitating their interoperability. ArchiMed is a data management system locally integrated for 5 years in a clinical environment. Not restricted to Neuroimaging, ArchiMed deals with multi-modal and multi-organs imaging data with specific considerations for data long-term conservation and confidentiality in accordance with the French legislation. Shanoir and ArchiMed are integrated into FLI-IAM1, the national French IT infrastructure for in vivo imaging.
Author: Yikang Liu
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Resting-state functional magnetic resonance imaging (rsfMRI) is a non-invasive method to study brain function and organization. The last decades have seen a dramatic growth of human rsfMRI studies, public datasets, and data analysis software, which advanced our understanding of neuroscience and brain diseases. However, studies and resources of rodent rsfMRI are still lacking, despite its essential role in translational research. In this dissertation, we first present an open database of rsfMRI data collected from 90 awake rats with a well-established awake imaging paradigm that avoids anesthesia interference, together with a preprocessing pipeline optimized for rat data. Based on this dataset, we propose two methods termed SHERM and fastClean towards automated preprocessing of rodent rsfMRI data. First, SHERM targets rodent brain extraction, which is an essential step to aid with rsfMRI image registration. Current methods usually require manual adjustment of input parameters due to widely different image qualities and/or contrasts. SHERM, however, only requires a brain template mask as the input and is shown to automatically and reliably extract the brain tissue in both rat and mouse MRI images. fastClean is an unsupervised deep learning method that removes rsfMRI artifacts induced by the scanner, head motion, and non-neural physiological noise. Existing machine learning methods either perform unsatisfactorily in low-dimensional rodent data or suffer from long online training. With an efficient network architecture and meta-learning techniques, fastClean generates equivalently clean or cleaner data in minutes on both rodent and human datasets. Finally, we systematically investigated the spatiotemporal dynamics of spontaneous brain activity in the awake rat brain with a graph-based data mining method. We found that brain activity traverse among multiple resting-state functional connectivity patterns with nonrandom and reproducible sequential orders and time delays, revealed a network structure of these transition paths, and showed prominent brain regions involved and their temporal evolutions during the propagation of spontaneous brain activity. Taken together, this dissertation presents multiple computational methods for rsfMRI studies, demonstrates their contribution to automatic data preprocessing, data cleaning, and spatiotemporal neural pattern discovery, and advances our understanding of network organization and dynamics of the awake rat brain.
Author: Yuhui Du
Publisher: Frontiers Media SA
ISBN: 2889634043
Category :
Languages : en
Pages : 288
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Book Description
There has been increasing interests in exploring biomarkers from brain images, aiming to have a better understanding and a more effective diagnosis of brain disorders such as schizophrenia, bipolar disorder, schizoaffective disorder, autism spectrum disorder, attention-deficit/hyperactivity disorder, Alzheimer’s disease and so on. Therefore, it is important to identify disease-specific changes for distinguishing healthy controls and patients with brain disorders as well as for differentiating patients with different disorders showing similar clinical symptoms. Biomarkers can be identified from different types of brain Imaging techniques including functional magnetic resonance imaging (fMRI), structural MRI, positron emission tomography (PET), electroencephalography (EEG), and magnetoencephalography (MEG) by using statistical analysis methods. Furthermore, based on measures from brain imaging techniques, machine learning techniques can help to classify or predict disease for individual subjects. In fact, fusion of features from multiple modalities may benefit the understanding of disease mechanism and improve the classification performance. This Research Topic further explores the functional or structural alterations in brain disorders.
